Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - Tight junction - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| WASL | O00401 | PTPN2, |
| SLC9A3R1 | O14745 | PTP4A3, PPP2CA, PPP2CB, |
| ERBB2 | P04626 | ACPP, PTPN9, DUSP3, PTPN6, PTPN12, PTPN11, PTPN18, PTPN11, |
| JUN | P05412 | PPP3CA, PPP3CB, PPP3CC, |
| ITGB1 | P05556 | PPP2CA, PPP2CB, PTP4A3, |
| CDK4 | P11802 | CDC25A, |
| ACTN1 | P12814 | PTPN1, PTPN6, |
| SRC | P12931 | PTPN23, ACP1, PPP2CA, PPP2CB, PTPN1, PTPN21, PTPN12, PTPRA, PTPRE, PTPRJ, PTPRH, PTPN6, PTPN11, PTPN2, |
| EZR | P15311 | PTP4A3, |
| PRKACA | P17612 | PPP2CA, PPP2CB, |
| MSN | P26038 | PPM1A, PPM1B, |
| PRKCI | P41743 | PPP2CA, PPP2CB, |
| WAS | P42768 | PTPN12, |
| MAPK8 | P45983 | DUSP22, DUSP8, DUSP18, DUSP1, DUSP9, DUSP10, PPP2CA, PPP2CB, DUSP3, |
| MAPK9 | P45984 | DUSP19, DUSP1, DUSP4, DUSP9, DUSP10, DUSP16, DUSP3, DUSP14, |
| VASP | P50552 | PPP2CA, PPP2CB, PPP3CA, PPP3CB, PPP3CC, |
| MAPK10 | P53779 | DUSP16, |
| TJP1 | Q07157 | PTPRJ, PTPN1, |
| PRKAA1 | Q13131 | PPP2CA, PPP2CB, |
| CTTN | Q14247 | PTPN1, |
| OCLN | Q16625 | PTPRJ, |
| PARD3 | Q8TEW0 | PPP1CA, PTPRK, |
| MAP3K5 | Q99683 | PGAM5, PPM1L, PPP5C, |
| Non-protein substrates in this pathway |
Non-protein substrates involved in this pathway are unknown (yet!)