Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
299 KEGG pathways;
876 Reactome pathways;
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023




Gene Name MAP3K5 (QuickGO)
Interactive visualization of MAP3K5 structures
(A quick tutorial to explore the interctive visulaization)

Representative structure: 4BID

SynonymsMAP3K5, ASK1, MAPKKK5, MEKK5
Protein NameMAP3K5
Alternative Name(s)
Mitogen-activated protein kinase kinase kinase 5;;Apoptosis signal-regulating kinase 1;ASK-1;MAPK/ERK kinase kinase 5;MEK kinase 5;MEKK 5;
Protein FamilyBelongs to the protein kinase superfamily STE Ser/Thrprotein kinase family MAP kinase kinase kinase subfamily
EntrezGene ID4217   (Comparitive Toxicogenomics)
UniProt AC (Human)Q99683 (protein sequence)
Enzyme Class2.7.11.25 (BRENDA )
Molecular Weight154537 Dalton
Protein Length1374 amino acids (AA)
Genome Browsers NCBI | ENSG00000197442 (Ensembl) | UCSC
Crosslinking annotations Query our ID-mapping table
Orthologues Quest For Orthologues (QFO) | GeneTree | eggNOG - KOG4279 | eggNOG - ENOG410XQGS
Phosphorylation Network Visualize
Domain organization, Expression, Diseases(show / hide)
Localization, Function, Catalytic activity and Sequence(show / hide)
Motif information from Eukaryotic Linear Motif atlas (ELM)(show / hide)
Gene Ontology (P: Process; F: Function and C: Component terms)(show / hide)