DEPOD - human DEPhOsphorylation Database

Name	UniProt AC	Dephosphorylates following protein substrates:	Dephosphorylates following non-protein substrates:
PTPN11	Q06124	SPRY2, SPRY1, JAK2, MPZL1, EGFR, PDGFRB, SRC, SELE, IRS1, KDR, STAT1, STAT5A, PXN, STAT5B, SIRPA, ARHGAP5, GAB1, PTK2B, PAG1, GAB2, MAP3K4, ERBB2, LCK, CD28, ERBB2, PDCD1, ERBB4,	Non-protein substrates of this phosphatase are not reported yet

Name	UniProt AC	Dephosphorylated by:
IKBKB	O14920	PPP2CA, PPP2CB, PPM1A, PPM1B, PPM1M,
ABL1	P00519	PTPN18, PTPN12,
RAF1	P04049	CDC25A, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPP5C, PTPN1,
NTRK1	P04629	PTPRZ1, PTPRS, PTPN6,
TP53	P04637	CDC14A, CDC14B, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPM1D, DUSP26,
JUN	P05412	PPP3CA, PPP3CB, PPP3CC,
BCL2	P10415	PPP2CA, PPP2CB,
PLCG1	P19174	PTPN1, PTPRJ,
NFKBIA	P25963	PTPN1, PTPN13, PPP3CB, PPP3CC, PPP2CB, PPP2CA, PPP3CA,
MAPK3	P27361	CDC25A, DUPD1, PTPN7, DUSP5, DUSP1, DUSP4, DUSP9, DUSP23, PTPRE, PTPRJ, DUSP3, PPP2CA, PTPRR, DUSP14,
PIK3R1	P27986	PPM1A, PTPRJ,
MAPK1	P28482	CDC25A, DUSP22, DUPD1, PTPN7, DUSP5, DUSP1, DUSP4, DUSP6, DUSP9, DUSP7, DUSP2, PPP2CA, PPP2CB, PTPRE, PTPRJ, DUSP3, PTPRR,
SHC1	P29353	PTEN, PTPN2,
AKT1	P31749	ACP1, PHLPP1, PHLPP2, PPP2CA, PPP2CB, PPP1CA, PPP1CB, PPP1CC, CTDSP1,
AKT2	P31751	PHLPP1, PHLPP2,
IRS1	P35568	PTPN1, PTPN13, PTPN11, PPP1CA, PPP1CB, PPP1CC,
MAPK8	P45983	DUSP22, DUSP8, DUSP18, DUSP1, DUSP9, DUSP10, PPP2CA, PPP2CB, DUSP3,
MAPK9	P45984	DUSP19, DUSP1, DUSP4, DUSP9, DUSP10, DUSP16, DUSP3, DUSP14,
CRK	P46108	PTPN1,
MAPKAPK2	P49137	PPP2CA, PPP2CB,
GSK3B	P49841	EPM2A, PPP3CA, PPP3CB, PPP3CC, PTPN1,
RPS6KA3	P51812	PPP2CA, PPP2CB, PPM1D,
MAPK12	P53778	PTPN3,
MAPK10	P53779	DUSP16,
MAP2K1	Q02750	PPP2CA, PPP2CB,
RELA	Q04206	PPP2CA, PPP4C, PPP2CB,
PRKCD	Q05655	PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPM1A,
PTPN11	Q06124	PTPN1,
BAX	Q07812	PPP2CA, PPP2CB,
MAPK7	Q13164	PTPRR,
GAB1	Q13480	PTPN1, PTPN11,
CAMK2B	Q13554	PPP2CA, PPP2CB,
CAMK2G	Q13555	PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, CTDSPL,
RPS6KA1	Q15418	PPP2CA, PPP2CB,
NTRK3	Q16288	PTPRO, PTPRS,
MAPK14	Q16539	DUSP22, DUPD1, PTPN7, DUSP8, DUSP1, DUSP9, DUSP10, DUSP2, PPP2CA, PPP2CB, PPM1A, PPM1D, DUSP26, DUSP3, DUSP14,
CAMK4	Q16566	PPM1F, PPM1E, PPP2CA, PPP2CB,
NTRK2	Q16620	PTPRS,
BAD	Q92934	ALPL, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPP3CA, PPP3CB, PPP3CC, PPM1B, PPP5C,
MAP3K5	Q99683	PGAM5, PPM1L, PPP5C,
CAMK2A	Q9UQM7	PPM1F, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB,
AKT3	Q9Y243	PHLPP1, PHLPP2, PPP2CA, PPP2CB,
ARHGDIA	P52565	PPM1B,

ChEBI ID	KEGG ID	ChEBIasciiName	Molecule	Dephosphorylated by:
CHEBI:16595	C01245	1D-myo-inositol 1,4,5-trisphosphate		INPP5B, INPP5A, INPP5E, INPP5J, INPP5K, OCRL, SYNJ1, SYNJ2,
CHEBI:16618	C05981	1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate		TNS2, FIG4, INPP5B, INPP5E, INPP5K, OCRL, PTEN, PTPRQ, INPP5F, INPP5D, INPPL1, SYNJ1, SYNJ2, TPTE2,

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KEGG Pathway - Neurotrophin signaling pathway - Homo sapiens (human)

Phosphatases regulating this pathway

Protein substrates in this pathway

Non-protein substrates in this pathway