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KEGG Pathway - Sphingolipid signaling pathway - Homo sapiens (human) Name UniProt AC Dephosphorylates following protein substrates: Dephosphorylates following non-protein substrates: PTEN P60484 PDGFRB , CREB1 , SHC1 , PTEN , PTK2 , PTK6 , 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate , 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate , 1D-myo-inositol 1,3,4,5-tetrakisphosphate , 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate , 1-phosphatidyl-1D-myo-inositol 3-phosphate , PPP2CB P62714 SLC9A3R1 , CHEK1 , IKBKB , CHUK , AXIN1 , MAP3K7 , CHEK2 , MYC , CRYAA , MBP , RAF1 , TP53 , HSPB1 , ITGB1 , PRKCB , KRT8 , RB1 , CDK1 , RHO , VIM , BCL2 , MAPT , NEFH , SRC , EEF2 , H2AFX , CREB1 , PRKCA , PRKACA , RPS6KB1 , CDK2 , CAD , MAPK1 , RBL1 , AKT1 , ELF1 , SNCA , IL6ST , PRKCI , CASP3 , MAPK8 , MAP2K4 , CDKN1B , PXN , MAPKAPK2 , CSNK1E , VASP , CDK9 , RPS6KA3 , PLK1 , BCAR1 , HIST1H3A , SMAD3 , MDM2 , MAP2K1 , GAD2 , PRKCD , BAX , GOLGA2 , RBL2 , TRAF2 , STK4 , PRKAA1 , PAK1 , STK3 , ATM , PPP1R1A , CAMK2B , CAMK2G , BMPR2 , PRKG1 , CAMK1 , CDK5R1 , PRKD1 , PPP2R5A , RPS6KA1 , SMAD1 , MAPK14 , CAMK4 , PNCK , PACS1 , HDAC7 , BAD , GAD1 , SMO , CARD11 , RACGAP1 , SPHK1 , PPP1R1B , CAMK2A , AKT3 , EIF4E , RPA2 , APC , NFKBIA , RELA , RYR2 , Non-protein substrates of this phosphatase are not reported yet PPP2CA P67775 SLC9A3R1 , CHEK1 , IKBKB , CHUK , AXIN1 , MAP3K7 , CHEK2 , MYC , CRYAA , MBP , RAF1 , TP53 , HSPB1 , ITGB1 , PRKCB , KRT8 , RB1 , CDK1 , RHO , VIM , BCL2 , MAPT , NEFH , SRC , EEF2 , H2AFX , CREB1 , PRKCA , PRKACA , RPS6KB1 , CDK2 , CAD , MAPK1 , RBL1 , AKT1 , ELF1 , SNCA , IL6ST , PRKCI , CASP3 , MAPK8 , MAP2K4 , CDKN1B , PXN , MAPKAPK2 , CSNK1E , VASP , CDK9 , RPS6KA3 , PLK1 , BCAR1 , HIST1H3A , SMAD3 , MDM2 , MAP2K1 , RELA , GAD2 , PRKCD , BAX , GOLGA2 , RBL2 , TRAF2 , STK4 , PRKAA1 , PAK1 , STK3 , ATM , PPP1R1A , CAMK2B , CAMK2G , BMPR2 , PRKG1 , CAMK1 , CDK5R1 , PRKD1 , PPP2R5A , RPS6KA1 , SMAD1 , MAPK14 , CAMK4 , PNCK , PACS1 , HDAC7 , BAD , GAD1 , SMO , CARD11 , RACGAP1 , SPHK1 , PPP1R1B , CAMK2A , AKT3 , EIF4E , RPA2 , APC , NFKBIA , MAPK3 , RYR2 , SLC6A3 , PTEN , Non-protein substrates of this phosphatase are not reported yet SGPP2 Q8IWX5 Protein substrates of this phosphatase are not reported yet sphinganine 1-phosphate , sphingosine 1-phosphate , SGPP1 Q9BX95 Protein substrates of this phosphatase are not reported yet sphinganine 1-phosphate , sphingosine 1-phosphate , phytosphingosine 1-phosphate ,
Name UniProt AC Dephosphorylated by: RAF1 P04049 CDC25A , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPP5C , PTPN1 , TP53 P04637 CDC14A , CDC14B , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPM1D , DUSP26 , PRKCB P05771 PHLPP1 , PHLPP2 , PPP1CA , PPP2CA , PPP2CB , FYN P06241 PTPRC , PTPN18 , PTPRA , PTPRE , PTPRJ , PTPN5 , BCL2 P10415 PPP2CA , PPP2CB , PRKCA P17252 PHLPP1 , PHLPP2 , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , MAPK3 P27361 CDC25A , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP9 , DUSP23 , PTPRE , PTPRJ , DUSP3 , PPP2CA , PTPRR , DUSP14 , PIK3R1 P27986 PPM1A , PTPRJ , MAPK1 P28482 CDC25A , DUSP22 , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP6 , DUSP9 , DUSP7 , DUSP2 , PPP2CA , PPP2CB , PTPRE , PTPRJ , DUSP3 , PTPRR , NOS3 P29474 PPP1CA , PPP1CB , PPP1CC , AKT1 P31749 ACP1 , PHLPP1 , PHLPP2 , PPP2CA , PPP2CB , PPP1CA , PPP1CB , PPP1CC , CTDSP1 , AKT2 P31751 PHLPP1 , PHLPP2 , MAPK8 P45983 DUSP22 , DUSP8 , DUSP18 , DUSP1 , DUSP9 , DUSP10 , PPP2CA , PPP2CB , DUSP3 , MAPK9 P45984 DUSP19 , DUSP1 , DUSP4 , DUSP9 , DUSP10 , DUSP16 , DUSP3 , DUSP14 , MAPK12 P53778 PTPN3 , MAPK10 P53779 DUSP16 , PTEN P60484 PTEN , PPP2CA , MAP2K1 Q02750 PPP2CA , PPP2CB , RELA Q04206 PPP2CA , PPP4C , PPP2CB , BAX Q07812 PPP2CA , PPP2CB , TRAF2 Q12933 PPP2CA , PPP2CB , PPP2R5A Q15172 PPP2CA , PPP2CB , MAPK14 Q16539 DUSP22 , DUPD1 , PTPN7 , DUSP8 , DUSP1 , DUSP9 , DUSP10 , DUSP2 , PPP2CA , PPP2CB , PPM1A , PPM1D , DUSP26 , DUSP3 , DUSP14 , MAP3K5 Q99683 PGAM5 , PPM1L , PPP5C , SPHK1 Q9NYA1 PPP2CA , PPP2CB , GAB2 Q9UQC2 PTPN6 , PTPN11 , AKT3 Q9Y243 PHLPP1 , PHLPP2 , PPP2CA , PPP2CB ,
ChEBI ID KEGG ID ChEBIasciiName Molecule Dephosphorylated by: CHEBI:17553 C00346 O-phosphoethanolamine PHOSPHO1 , CHEBI:16595 C01245 1D-myo-inositol 1,4,5-trisphosphate INPP5B , INPP5A , INPP5E , INPP5J , INPP5K , OCRL , SYNJ1 , SYNJ2 , CHEBI:16618 C05981 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate TNS2 , FIG4 , INPP5B , INPP5E , INPP5K , OCRL , PTEN , PTPRQ , INPP5F , INPP5D , INPPL1 , SYNJ1 , SYNJ2 , TPTE2 , CHEBI:37550 C06124 sphingosine 1-phosphate PLPP1 , PLPP3 , PLPP2 , SGPP1 , SGPP2 ,
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