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PHOSPHO1
Localization (UniProt annotation) N/A Function (UniProt annotation) Phosphatase that has a high activity towardphosphoethanolamine (PEA) and phosphocholine (PCho) Involved inthe generation of inorganic phosphate for bone mineralization Catalytic Activity (UniProt annotation) O-phosphoethanolamine + H(2)O = ethanolamine +phosphate Phosphocholine + H(2)O = choline + phosphate Protein Sequence MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLRATYREGFYNEYMQRVFKYLG
EQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVILISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLAL
RPFHTHSCARCPANMCKHKVLSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEP
SSFRASVVPWETAADVRLHLQQVLKSC
ELM Motif Motif Instance Description Motif Regex NA NA NA NA
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-1483191 Synthesis of PC. De novo (Kennedy pathway) synthesis of phosphatidylcholine (PC) involves phosphorylation of choline (Cho) to phosphocholine (PCho) followed by condensing with cytidine triphosphate (CTP) to form CDP-choline (CDP-Cho). Diacylglycerol (DAG) and CDP-ETA together then form PC. Alternatively, PC is formed when phosphatidylethanolamine (PE) is methylated by phosphatidylethanolamine N-methyltransferase (PEMT) (Henneberry et al. 2002; Wright & McMaster 2002)R-HSA-1483213 Synthesis of PE. De novo (Kennedy pathway) synthesis of phosphatidylethanolamine (PE) involves phosphorylation of ethanolamine (ETA) to phosphoethanolamine (PETA) followed by condensing with cytidine triphosphate (CTP) to form CDP-ethanolamine (CDP-ETA). Diacylglycerol (DAG) and CDP-ETA together then form PE. Alternatively, PE is formed when phosphatidylserine (PS) is decarboxylated by phosphatidylserine decarboxylase proenzyme (PISD) (Henneberry et al. 2002, Vance 1991, Vance 1990)
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source CCT3 pull down association 28330616 , (Europe PMC )0.35 IntAct CCT4 pull down association 28330616 , (Europe PMC )0.35 IntAct CCT5 pull down association 28330616 , (Europe PMC )0.35 IntAct CCT6A pull down association 28330616 , (Europe PMC )0.35 IntAct CCT7 pull down association 28330616 , (Europe PMC )0.35 IntAct CKB pull down association 28330616 , (Europe PMC )0.35 IntAct CS pull down association 28330616 , (Europe PMC )0.35 IntAct DDX39A pull down association 28330616 , (Europe PMC )0.35 IntAct ECHS1 pull down association 28330616 , (Europe PMC )0.35 IntAct EIF5A pull down association 28330616 , (Europe PMC )0.35 IntAct FKBP4 pull down association 28330616 , (Europe PMC )0.35 IntAct GANAB pull down association 28330616 , (Europe PMC )0.35 IntAct GOT2 pull down association 28330616 , (Europe PMC )0.35 IntAct GPI pull down association 28330616 , (Europe PMC )0.35 IntAct HINT1 pull down association 28330616 , (Europe PMC )0.35 IntAct HMGB2 pull down association 28330616 , (Europe PMC )0.35 IntAct HSPA4 pull down association 28330616 , (Europe PMC )0.35 IntAct HSPD1 pull down association 28330616 , (Europe PMC )0.35 IntAct HSPE1 pull down association 28330616 , (Europe PMC )0.35 IntAct KHSRP pull down association 28330616 , (Europe PMC )0.35 IntAct LDHA pull down association 28330616 , (Europe PMC )0.35 IntAct MARCKS pull down association 28330616 , (Europe PMC )0.35 IntAct MDH2 pull down association 28330616 , (Europe PMC )0.35 IntAct NME2 pull down association 28330616 , (Europe PMC )0.35 IntAct OAT pull down association 28330616 , (Europe PMC )0.35 IntAct P4HB pull down association 28330616 , (Europe PMC )0.35 IntAct PA2G4 pull down association 28330616 , (Europe PMC )0.35 IntAct PARK7 pull down association 28330616 , (Europe PMC )0.35 IntAct PDCD5 pull down association 28330616 , (Europe PMC )0.35 IntAct PDIA3 pull down association 28330616 , (Europe PMC )0.35 IntAct PDIA6 pull down association 28330616 , (Europe PMC )0.35 IntAct PEBP1 pull down association 28330616 , (Europe PMC )0.35 IntAct PFN1 pull down association 28330616 , (Europe PMC )0.35 IntAct PGAM1 pull down association 28330616 , (Europe PMC )0.35 IntAct PGK1 pull down association 28330616 , (Europe PMC )0.35 IntAct PPIB pull down association 28330616 , (Europe PMC )0.35 IntAct PRDX6 pull down association 28330616 , (Europe PMC )0.35 IntAct PRKCSH pull down association 28330616 , (Europe PMC )0.35 IntAct PTGES3 pull down association 28330616 , (Europe PMC )0.35 IntAct RANBP1 pull down association 28330616 , (Europe PMC )0.35 IntAct RPN1 pull down association 28330616 , (Europe PMC )0.35 IntAct STMN1 pull down association 28330616 , (Europe PMC )0.35 IntAct TCP1 pull down association 28330616 , (Europe PMC )0.35 IntAct TKT pull down association 28330616 , (Europe PMC )0.35 IntAct TMEM97 pull down association 28330616 , (Europe PMC )0.35 IntAct TPI1 pull down association 28330616 , (Europe PMC )0.35 IntAct TRAP1 pull down association 28330616 , (Europe PMC )0.35 IntAct UBA1 pull down association 28330616 , (Europe PMC )0.35 IntAct UBE2N pull down association 28330616 , (Europe PMC )0.35 IntAct UCHL1 pull down association 28330616 , (Europe PMC )0.35 IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source CCT2 pull down association 28330616 , (Europe PMC )0.35 IntAct CCT3 pull down association 28330616 , (Europe PMC )0.35 IntAct CCT4 pull down association 28330616 , (Europe PMC )0.35 IntAct CCT5 pull down association 28330616 , (Europe PMC )0.35 IntAct CCT6A pull down association 28330616 , (Europe PMC )0.35 IntAct CCT7 pull down association 28330616 , (Europe PMC )0.35 IntAct CHTF18 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID CKB pull down association 28330616 , (Europe PMC )0.35 IntAct CS pull down association 28330616 , (Europe PMC )0.35 IntAct DDX39A pull down association 28330616 , (Europe PMC )0.35 IntAct ECHS1 pull down association 28330616 , (Europe PMC )0.35 IntAct EIF5A pull down association 28330616 , (Europe PMC )0.35 IntAct FKBP4 pull down association 28330616 , (Europe PMC )0.35 IntAct GANAB pull down association 28330616 , (Europe PMC )0.35 IntAct GOT2 pull down association 28330616 , (Europe PMC )0.35 IntAct GPI pull down association 28330616 , (Europe PMC )0.35 IntAct HINT1 pull down association 28330616 , (Europe PMC )0.35 IntAct HLA-DMB Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID HLA-DRB1 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID HMGB2 pull down association 28330616 , (Europe PMC )0.35 IntAct HSPA4 pull down association 28330616 , (Europe PMC )0.35 IntAct HSPD1 pull down association 28330616 , (Europe PMC )0.35 IntAct HSPE1 pull down association 28330616 , (Europe PMC )0.35 IntAct KHSRP pull down association 28330616 , (Europe PMC )0.35 IntAct LDHA pull down association 28330616 , (Europe PMC )0.35 IntAct MARCKS pull down association 28330616 , (Europe PMC )0.35 IntAct MDH2 pull down association 28330616 , (Europe PMC )0.35 IntAct NME2 pull down association 28330616 , (Europe PMC )0.35 IntAct OAT pull down association 28330616 , (Europe PMC )0.35 IntAct P4HB pull down association 28330616 , (Europe PMC )0.35 IntAct PA2G4 pull down association 28330616 , (Europe PMC )0.35 IntAct PARK7 pull down association 28330616 , (Europe PMC )0.35 IntAct PDCD5 pull down association 28330616 , (Europe PMC )0.35 IntAct PDIA3 pull down association 28330616 , (Europe PMC )0.35 IntAct PDIA6 pull down association 28330616 , (Europe PMC )0.35 IntAct PEBP1 pull down association 28330616 , (Europe PMC )0.35 IntAct PFN1 pull down association 28330616 , (Europe PMC )0.35 IntAct PGAM1 pull down association 28330616 , (Europe PMC )0.35 IntAct PGK1 pull down association 28330616 , (Europe PMC )0.35 IntAct PPIB pull down association 28330616 , (Europe PMC )0.35 IntAct PRDX6 pull down association 28330616 , (Europe PMC )0.35 IntAct PRKCSH pull down association 28330616 , (Europe PMC )0.35 IntAct PTGES3 pull down association 28330616 , (Europe PMC )0.35 IntAct RANBP1 pull down association 28330616 , (Europe PMC )0.35 IntAct RPN1 pull down association 28330616 , (Europe PMC )0.35 IntAct STMN1 pull down association 28330616 , (Europe PMC )0.35 IntAct TCP1 pull down association 28330616 , (Europe PMC )0.35 IntAct TKT pull down association 28330616 , (Europe PMC )0.35 IntAct TMEM97 pull down association 28330616 , (Europe PMC )0.35 IntAct TPI1 pull down association 28330616 , (Europe PMC )0.35 IntAct TRAP1 pull down association 28330616 , (Europe PMC )0.35 IntAct UBA1 pull down association 28330616 , (Europe PMC )0.35 IntAct UBE2N pull down association 28330616 , (Europe PMC )0.35 IntAct UCHL1 pull down association 28330616 , (Europe PMC )0.35 IntAct