Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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KEGG Pathway - Glycerophospholipid metabolism - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| PLPP1 | O14494 | Protein substrates of this phosphatase are not reported yet | N-acylsphingosine 1-phosphate, phosphatidic acid, 1-acyl-sn-glycerol 3-phosphate, sphingosine 1-phosphate, |
| PLPP3 | O14495 | Protein substrates of this phosphatase are not reported yet | N-acylsphingosine 1-phosphate, phosphatidic acid, 1-acyl-sn-glycerol 3-phosphate, sphingosine 1-phosphate, |
| PLPP2 | O43688 | Protein substrates of this phosphatase are not reported yet | N-acylsphingosine 1-phosphate, phosphatidic acid, 1-acyl-sn-glycerol 3-phosphate, sphingosine 1-phosphate, |
| LPIN1 | Q14693 | Protein substrates of this phosphatase are not reported yet | phosphatidic acid, |
| PLPP4 | Q5VZY2 | Protein substrates of this phosphatase are not reported yet | phosphatidic acid, 1-acyl-sn-glycerol 3-phosphate, |
| PLPP5 | Q8NEB5 | Protein substrates of this phosphatase are not reported yet | phosphatidic acid, 1-acyl-sn-glycerol 3-phosphate, |
| PHOSPHO1 | Q8TCT1 | Protein substrates of this phosphatase are not reported yet | O-phosphoethanolamine, phosphocholine, |
| LPIN2 | Q92539 | Protein substrates of this phosphatase are not reported yet | phosphatidic acid, |
| LPIN3 | Q9BQK8 | Protein substrates of this phosphatase are not reported yet | phosphatidic acid, |
| Protein substrates in this pathway |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:15978 | C00093 | sn-glycerol 3-phosphate |  | PGP, |
| CHEBI:17553 | C00346 | O-phosphoethanolamine |  | PHOSPHO1, |
| CHEBI:16337 | C00416 | phosphatidic acid |  | ACPP, PLPP5, PLPP4, LPIN1, LPIN2, LPIN3, PLPPR2, PLPPR3, PLPPR4, PLPP1, PLPP3, PLPP2, PLPP6, |
| CHEBI:18132 | C00588 | phosphocholine |  | PHOSPHO1, |
| CHEBI:16975 | C00681 | 1-acyl-sn-glycerol 3-phosphate |  | ACP6, ACPP, PLPP5, PLPP4, PLPPR4, PLPP1, PLPP3, PLPP2, EPHX2, |
| CHEBI:37393 | C03892 | 1-(3-sn-phosphatidyl)-sn-glycerol 3-phosphate |  | PTPMT1, |