Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
299 KEGG pathways;
876 Reactome pathways;
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023



Name sn-glycerol 3-phosphateC00093
Download: mol | sdf
Synonyms0(2r)-2,3-dihydroxypropyl dihydrogen phosphate; sn-glycerol 3-(dihydrogen phosphate);
(r)-glycerol 1-phosphate;
D-glycerol 1-phosphate;
Glycerophosphoric acid;
Phosphoric acid mono-((r)-2,3-dihydroxy-propyl) ester;
Sn-glycerol 3-phosphate;
Definition An sn-glycerol 3-phosphate having unsubstituted hydroxy groups.
Molecular Weight
(Exact mass)
172.0737 (172.0137)
Molecular Formula C3H9O6P
InChI InChI=1S/C3H9O6P/c4-1-3(5)2-9-10(6,7)8/h3-5H,1-2H2,(H2,6,7,8)/t3-/m1/s1
Crosslinking annotations KEGG:C00093 | 3DMET:B01157 | CAS:17989-41-2 | ChEBI:15978 | ChEMBL:CHEMBL1232920 | KNApSAcK:C00007288 | NIKKAJI:J4.456C | PDB-CCD:G3P | PDB-CCD:GP9 | PubChem:3393 |

Pathway ID Pathway Name Pathway Description (KEGG)
map00561Glycerolipid metabolismNA
map00564Glycerophospholipid metabolismNA
map01100Metabolic pathwaysNA
map01110Biosynthesis of secondary metabolitesNA
map02010ABC transportersThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
map05231Choline metabolism in cancerAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS and PI3K-AKT pathways, and transcription factors associated with oncogenesis such as hypoxia-inducible factor 1 (HIF1) mediate overexpression and activation of choline cycle enzymes, which causes increased levels of choline-containing precursors and breakdown products of membrane phospholipids. These products of choline phospholipid metabolism, such as phosphocholine (PCho), diacylglycerol (DAG) and phosphatidic acid, may function as second messengers that are essential for the mitogenic activity of growth factors, particularly in the activation of the ras-raf-1-MAPK cascade and protein kinase C pathway.