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KEGG Pathway - Regulation of actin cytoskeleton - Homo sapiens (human) Name UniProt AC Dephosphorylates following protein substrates: Dephosphorylates following non-protein substrates: PPP1CC P36873 FXYD1 , AURKA , AXIN1 , AHCYL1 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , CASP2 , TNNT2 , CSNK1E , HIST1H3A , CENPE , GAD2 , PTK2 , PRKCD , STK4 , STK3 , ATM , IKZF1 , CAMK2G , POLD3 , PRKD1 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , POLR2A , TTK , RYR2 , Non-protein substrates of this phosphatase are not reported yet PPP1CA P62136 AURKA , AXIN1 , AHCYL1 , TBC1D4 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , PRKCB , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , EIF2AK2 , LMNB1 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , BRCA1 , CASP2 , TNNT2 , CSNK1E , CDK9 , CASP9 , PPP1CA , GAD2 , PTK2 , PRKCD , STK4 , STK3 , IKZF1 , CAMK2G , POLD3 , PRKD1 , PARD3 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , SF3B1 , POLR2A , RYR2 , SRSF1 , SLC6A3 , SENP3 , Non-protein substrates of this phosphatase are not reported yet PPP1CB P62140 AURKA , AXIN1 , AHCYL1 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , CASP2 , TNNT2 , CSNK1E , GAD2 , PTK2 , PRKCD , STK4 , STK3 , IKZF1 , CAMK2G , POLD3 , PRKD1 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , POLR2A , RYR2 , CDC5L , Non-protein substrates of this phosphatase are not reported yet SSH2 Q76I76 CFL1 , Non-protein substrates of this phosphatase are not reported yet SSH3 Q8TE77 CFL1 , Non-protein substrates of this phosphatase are not reported yet SSH1 Q8WYL5 CFL1 , LIMK1 , DSTN , CORO1B , Non-protein substrates of this phosphatase are not reported yet
Name UniProt AC Dephosphorylated by: WASL O00401 PTPN2 , EGFR P00533 CDC25A , ACP1 , PTPN1 , PTPN9 , PTPRU , PTPRJ , PTPRK , PTPRS , PTPN6 , PTPN11 , PTPN2 , DUSP3 , UBASH3B , PTPRA , PTPRB , PTPN12 , PTPRH , RAF1 P04049 CDC25A , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPP5C , PTPN1 , ITGB1 P05556 PPP2CA , PPP2CB , PTP4A3 , PDGFRB P09619 ACP1 , PTEN , PTPN1 , PTPRJ , PTPN11 , PTPN2 , DUSP3 , ACTN1 P12814 PTPN1 , PTPN6 , SRC P12931 PTPN23 , ACP1 , PPP2CA , PPP2CB , PTPN1 , PTPN21 , PTPN12 , PTPRA , PTPRE , PTPRJ , PTPRH , PTPN6 , PTPN11 , PTPN2 , EZR P15311 PTP4A3 , FGFR2 P21802 DUSP3 , CFL1 P23528 PDXP , SSH1 , SSH2 , SSH3 , MSN P26038 PPM1A , PPM1B , MAPK3 P27361 CDC25A , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP9 , DUSP23 , PTPRE , PTPRJ , DUSP3 , PPP2CA , PTPRR , DUSP14 , PIK3R1 P27986 PPM1A , PTPRJ , MAPK1 P28482 CDC25A , DUSP22 , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP6 , DUSP9 , DUSP7 , DUSP2 , PPP2CA , PPP2CB , PTPRE , PTPRJ , DUSP3 , PTPRR , WAS P42768 PTPN12 , CRK P46108 PTPN1 , PXN P49023 PPP2CA , PPP2CB , PTPRT , PTPN11 , LIMK1 P53667 SSH1 , BCAR1 P56945 PPP2CA , PPP2CB , PTP4A3 , PTPN1 , PTPN12 , PTPRA , PTPRH , PPP1CA P62136 PPP1CA , MAP2K1 Q02750 PPP2CA , PPP2CB , PTK2 Q05397 PTPN23 , ACP1 , PPP1CA , PPP1CB , PPP1CC , PTEN , PTPN1 , PTPN12 , UBASH3B , PAK1 Q13153 PPM1F , PPM1E , PPP2CA , PPP2CB , PPM1A , PAK2 Q13177 PPM1A , SSH1 Q8WYL5 PPP3CA , PPP3CB , PPP3CC , ARHGAP35 Q9NRY4 PTPN18 , PTPRZ1 , APC P25054 PPP2CB , PPP2CA ,
ChEBI ID KEGG ID ChEBIasciiName Molecule Dephosphorylated by: CHEBI:16975 C00681 1-acyl-sn-glycerol 3-phosphate ACP6 , ACPP , PLPP5 , PLPP4 , PLPPR4 , PLPP1 , PLPP3 , PLPP2 , EPHX2 , CHEBI:18348 C04637 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate FIG4 , INPP5B , INPP5E , INPP5J , INPP5K , OCRL , PTP4A3 , PTPRQ , INPP5F , SYNJ1 , SYNJ2 , CHEBI:16618 C05981 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate TNS2 , FIG4 , INPP5B , INPP5E , INPP5K , OCRL , PTEN , PTPRQ , INPP5F , INPP5D , INPPL1 , SYNJ1 , SYNJ2 , TPTE2 , CHEBI:16152 C11554 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate INPP4A , INPP4B , PTEN , PTPRQ ,
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