Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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INPP4B
Gene Name  | INPP4B (QuickGO) | (A quick tutorial to explore the interctive visulaization) |
| Synonyms | INPP4B | |
| Protein Name | INPP4B |
|
| Alternative Name(s) |
Type II inositol 3,4-bisphosphate 4-phosphatase;3.1.3.66;Inositol polyphosphate 4-phosphatase type II; | |
| EntrezGene ID | 8821 (Comparitive Toxicogenomics) | |
| UniProt AC (Human) | O15327 (protein sequence) | |
| Enzyme Class | EC 3.1.3.66 (BRENDA ) | |
| Molecular Weight | 104738 Dalton | |
| Protein Length | 924 amino acids (AA) | |
| Genome Browsers | NCBI | ENSG00000109452 (Ensembl) | | |
| Crosslinking annotations | Query our ID-mapping table | |
| Orthologues | Quest For Orthologues (QFO) | GeneTree | |
| Classification | Superfamily: inositol-4-phosphatases | Historic class: Inositol-3,4-bisphosphate 4-phosphatase | CATH ID: NA | SCOP Fold: INPP4 | |
| Phosphatase activity | active | Catalytic signature motif: CCKSAKDR | |
| Phosphorylation Network | Visualize | |
| Domain organization, Expression, Diseases | (show / hide) |
| Protein Domain | InterPro | Pfam | SMART | 3D Structure | PDB | DrugPort | ModBase | SwissModel |
| Polypeptide organization (Pfam) | No Pfam domain found | ||
| Catalytic Site | Mechanism and Catalytic Site Atlas | ||
| Gene Expression | Gene Expression Atlas | Diseases | OMIM | COSMIC | ClinVar |
| Protein-protein interactions | STRING | IntAct | MINT | BioGRID | ||
| Phosphosites | Phospho.ELM | PhosphoSitePlus | ||
| Localization, Function, Catalytic activity and Sequence | (show / hide) |
| Localization (UniProt annotation) | |||
| N/A | |||
| Function (UniProt annotation) | |||
| Catalyzes the hydrolysis of the 4-position phosphate ofphosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate | |||
| Catalytic Activity (UniProt annotation) | |||
| 1-phosphatidyl-myo-inositol 3,4-bisphosphate +H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate | |||
| Protein Sequence | |||
| MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSS TEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKE QLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNSVLKNPVCKLYR FPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSK ETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFI YYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGG ILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEK EPSLTDAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFI IKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVK LPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQN DLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMR REGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT |
| Motif information from Eukaryotic Linear Motif atlas (ELM) | (show / hide) |
ELM Motif | Motif Instance | Description | Motif Regex |
| NA | NA | NA | NA |
| Gene Ontology (P: Process; F: Function and C: Component terms) | (show / hide) | |
| GO:0005737 | C:cytoplasm |
| GO:0005829 | C:cytosol |
| GO:0006661 | P:phosphatidylinositol biosynthetic process |
| GO:0007165 | P:signal transduction |
| GO:0016316 | F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity |
| GO:0017161 | F:inositol-1,3,4-trisphosphate 4-phosphatase activity |
| GO:0034597 | F:phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity |
| GO:0043647 | P:inositol phosphate metabolic process |
| GO:0052828 | F:inositol-3,4-bisphosphate 4-phosphatase activity |
