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DSTN
Localization (UniProt annotation) N/A Function (UniProt annotation) Actin-depolymerizing protein Severs actin filaments (F-actin) and binds to actin monomers (G-actin) Acts in a pH-independent manner Catalytic Activity (UniProt annotation) N/A Protein Sequence MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDVGVTITDPFKHFVGMLPEKDC
RYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAF
EGCPV
ELM Motif Motif Instance
Description Motif Regex NA NA NA NA
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ACTA1 Co-fractionation physical 8399167 , (Europe PMC )NA BioGRID ACTB Two-hybrid, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach, validated two hybrid physical, physical association 16189514 , 25416956 , (Europe PMC )0.76 BioGRID, IntAct ACTG1 Two-hybrid, mammalian protein protein interaction trap, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach, validated two hybrid physical, physical association 16189514 , 25416956 , (Europe PMC )0.78 BioGRID, IntAct ALDH4A1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID C12orf10 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID CDK2 Affinity Capture-MS physical 21319273 , (Europe PMC )NA BioGRID CFL2 Two-hybrid physical 25416956 , (Europe PMC )NA BioGRID CFTR Affinity Capture-MS physical 26618866 , (Europe PMC )NA BioGRID CRIP1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CROT Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID DNAJB12 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID DNPH1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID DPP3 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID EED Affinity Capture-MS physical 24457600 , (Europe PMC )NA BioGRID FOXA1 Affinity Capture-MS physical 27926873 , (Europe PMC )NA BioGRID G3BP1 Affinity Capture-MS physical 26777405 , (Europe PMC )NA BioGRID HIBCH Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HSPB8 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID HSPE1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HTRA2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID IGFBP7 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID ISG15 Affinity Capture-Western physical 16815975 , (Europe PMC )NA BioGRID ITGB1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID ITSN1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID KYNU Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID LAMTOR5 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID LDHA Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID LDHAL6A Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID LDHB Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID LIMD1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID MCFD2 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID MCM2 Affinity Capture-MS physical 25963833 , (Europe PMC )NA BioGRID MCM7 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID MDP1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID MEMO1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID MIF Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID MYH11 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID MYH9 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct MYO18A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct MYO1C Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct NME1-NME2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID NME2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID NMI Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID NPM1 Affinity Capture-MS physical 23402259 , (Europe PMC )NA BioGRID OTUB1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID OTULIN Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PALLD Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PCBP1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PDLIM5 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PEX19 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PIEZO1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PIR Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID POMP Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PPP1CB Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct PPP4R2 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PRDX5 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PSMD9 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PTMA Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PTMS Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PUM1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PXN Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID RNF114 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID RNH1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID RRBP1 Affinity Capture-MS physical 17353931 , (Europe PMC )NA BioGRID S100A9 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SEC23IP Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SEC24A Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SGTA Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SHBG Two-hybrid physical 15862967 , (Europe PMC )NA BioGRID SLIRP Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SMAD9 Two-hybrid, two hybrid physical, physical association 15231748 , (Europe PMC )0.37 BioGRID, IntAct, MINT SOD1 Affinity Capture-MS, Co-fractionation, cross-linking study association, physical 26344197 , 29128334 , (Europe PMC )0.35 BioGRID, IntAct SP100 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SPR Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID SRSF2 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SSH1 Biochemical Activity physical 11832213 , (Europe PMC )NA BioGRID ST13 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID STAT6 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID STMN2 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID TAX1BP1 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.70 BioGRID, IntAct TOM1L2 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID TPI1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TPM2 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID TSTA3 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID TTC1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID TUBA1C Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID UBA3 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID UBE2B Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID UNK Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID URM1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID VCP Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID WDR1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ZFYVE19 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ACTG1 Two-hybrid, mammalian protein protein interaction trap, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach, validated two hybrid physical, physical association 16189514 , 25416956 , (Europe PMC )0.78 BioGRID, IntAct EBI-1058536 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct EIF1B anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct GH1 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct IKBKE anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct JUN anti bait coimmunoprecipitation association 25609649 , (Europe PMC )0.35 IntAct, MINT KSR2 anti tag coimmunoprecipitation association 27086506 , (Europe PMC )0.35 IntAct MYH9 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct MYO18A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct MYO1C Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct PINX1 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct PPP1CB Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct SMAD9 Two-hybrid, two hybrid physical, physical association 15231748 , (Europe PMC )0.37 BioGRID, IntAct, MINT SOD1 Affinity Capture-MS, Co-fractionation, cross-linking study association, physical 26344197 , 29128334 , (Europe PMC )0.35 BioGRID, IntAct SPHK1 anti tag coimmunoprecipitation association 25216046 , (Europe PMC )0.35 IntAct TAX1BP1 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.70 BioGRID, IntAct TNIK anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ACTA1 Co-fractionation physical 8399167 , (Europe PMC )NA BioGRID ACTB Two-hybrid, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach, validated two hybrid physical, physical association 16189514 , 25416956 , (Europe PMC )0.76 BioGRID, IntAct ACTG1 Two-hybrid, mammalian protein protein interaction trap, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach, validated two hybrid physical, physical association 16189514 , 25416956 , (Europe PMC )0.78 BioGRID, IntAct ALDH4A1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID C12orf10 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID CDK2 Affinity Capture-MS physical 21319273 , (Europe PMC )NA BioGRID CFL2 Two-hybrid physical 25416956 , (Europe PMC )NA BioGRID CFTR Affinity Capture-MS physical 26618866 , (Europe PMC )NA BioGRID CRIP1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CROT Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID DNAJB12 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID DNPH1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID DPP3 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID EBI-1058536 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct EED Affinity Capture-MS physical 24457600 , (Europe PMC )NA BioGRID EIF1B anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct FOXA1 Affinity Capture-MS physical 27926873 , (Europe PMC )NA BioGRID G3BP1 Affinity Capture-MS physical 26777405 , (Europe PMC )NA BioGRID GH1 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct HIBCH Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HSPB8 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID HSPE1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HTRA2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID IGFBP7 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID IKBKE anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct ISG15 Affinity Capture-Western physical 16815975 , (Europe PMC )NA BioGRID ITGB1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID ITSN1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID JUN anti bait coimmunoprecipitation association 25609649 , (Europe PMC )0.35 IntAct, MINT KSR2 anti tag coimmunoprecipitation association 27086506 , (Europe PMC )0.35 IntAct KYNU Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID LAMTOR5 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID LDHA Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID LDHAL6A Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID LDHB Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID LIMD1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID MCFD2 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID MCM2 Affinity Capture-MS physical 25963833 , (Europe PMC )NA BioGRID MCM7 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID MDP1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID MEMO1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID MIF Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID MYH11 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID MYH9 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct MYO18A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct MYO1C Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct NME1-NME2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID NME2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID NMI Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID NPM1 Affinity Capture-MS physical 23402259 , (Europe PMC )NA BioGRID OTUB1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID OTULIN Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PALLD Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PCBP1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PDLIM5 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PEX19 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PIEZO1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PINX1 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct PIR Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID POMP Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PPP1CB Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct PPP4R2 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PRDX5 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PSMD9 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PTMA Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PTMS Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PUM1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PXN Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID RNF114 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID RNH1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID RRBP1 Affinity Capture-MS physical 17353931 , (Europe PMC )NA BioGRID S100A9 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SEC23IP Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SEC24A Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SGTA Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SHBG Two-hybrid physical 15862967 , (Europe PMC )NA BioGRID SLIRP Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SMAD9 Two-hybrid, two hybrid physical, physical association 15231748 , (Europe PMC )0.37 BioGRID, IntAct, MINT SOD1 Affinity Capture-MS, Co-fractionation, cross-linking study association, physical 26344197 , 29128334 , (Europe PMC )0.35 BioGRID, IntAct SP100 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SPHK1 anti tag coimmunoprecipitation association 25216046 , (Europe PMC )0.35 IntAct SPR Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID SRSF2 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SSH1 Biochemical Activity physical 11832213 , (Europe PMC )NA BioGRID ST13 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID STAT6 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID STMN2 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID TAX1BP1 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.70 BioGRID, IntAct TNIK anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct TOM1L2 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID TPI1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TPM2 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID TSTA3 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID TTC1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID TUBA1C Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID UBA3 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID UBE2B Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID UNK Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID URM1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID VCP Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID WDR1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ZFYVE19 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID
Phosphorylating Kinases Phosphoresidues Detection Method PubMed IDs Source
Visualize a network of protein kinases and phosphatases phosphorylating and dephosphorylating this protein respectively
LIMK1 S3_MAsGVQVADE , NA NA PhosphoSitePlus , LIMK2 S3_MAsGVQVADE , NA NA PhosphoSitePlus , TESK2 S3_MAsGVQVADE , in vitro, in vivo 11418599 , 19413330 , 19651622 , 20068231 ,(Europe PMC )HPRD, Unknown S24_DMKVRKCsTPEEIKK , S3_MAsGVQVADE , S7_MASGVQsADEVCRI , in vitro, in vivo 11418599 , 19413330 , 19651622 , 20068231 ,(Europe PMC )HPRD,