Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
REACTOME Pathway - Regulation of TP53 Degradation
 | Phosphatases regulating this pathway |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| CHEK2 | O96017 | PPP2CA, PPP2CB, PPM1D, |
| TP53 | P04637 | CDC14A, CDC14B, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPM1D, DUSP26, |
| CDK1 | P06493 | CDC25A, CDC25B, CDC25C, PPP2CA, PPP2CB, |
| CDK2 | P24941 | CDC25A, CDKN3, PPP2CA, PPP2CB, PPM1A, PPM1B, |
| AKT1 | P31749 | ACP1, PHLPP1, PHLPP2, PPP2CA, PPP2CB, PPP1CA, PPP1CB, PPP1CC, CTDSP1, |
| AKT2 | P31751 | PHLPP1, PHLPP2, |
| MDM2 | Q00987 | PPP2CA, PPP2CB, PPM1D, |
| ATM | Q13315 | PPP1CC, PPP2CA, PPP2CB, PPM1D, |
| AKT3 | Q9Y243 | PHLPP1, PHLPP2, PPP2CA, PPP2CB, |