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KEGG Pathway - Insulin resistance - Homo sapiens (human) Name UniProt AC Dephosphorylates following protein substrates: Dephosphorylates following non-protein substrates: PTPRF P10586 INSR , MET , PTPRF , CTNNB1 , Non-protein substrates of this phosphatase are not reported yet PTPN1 P18031 INPPL1 , LAT , JAK2 , CTNND1 , STAM2 , EGFR , ESR1 , RAF1 , INSR , IGF1R , MET , PDGFRB , GHR , ACTN1 , SRC , PTPN1 , PLCG1 , EPOR , RASA1 , NFKBIA , EPHA3 , PTPN6 , TYK2 , CTNNB1 , IRS1 , STAT3 , STAT6 , STAT5A , CRK , NSF , GSK3B , STAT5B , BCAR1 , CAV1 , PTK2 , PTPN11 , TJP1 , GAB1 , CTTN , ARHGAP12 , LPP , DOK1 , TRPV6 , ALK , PTK6 , PTK6 , PAG1 , Non-protein substrates of this phosphatase are not reported yet G6PC P35575 Protein substrates of this phosphatase are not reported yet alpha-D-glucose 6-phosphate , beta-D-glucose 6-phosphate , PPP1CC P36873 FXYD1 , AURKA , AXIN1 , AHCYL1 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , CASP2 , TNNT2 , CSNK1E , HIST1H3A , CENPE , GAD2 , PTK2 , PRKCD , STK4 , STK3 , ATM , IKZF1 , CAMK2G , POLD3 , PRKD1 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , POLR2A , TTK , RYR2 , Non-protein substrates of this phosphatase are not reported yet PTEN P60484 PDGFRB , CREB1 , SHC1 , PTEN , PTK2 , PTK6 , 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate , 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate , 1D-myo-inositol 1,3,4,5-tetrakisphosphate , 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate , 1-phosphatidyl-1D-myo-inositol 3-phosphate , PPP1CA P62136 AURKA , AXIN1 , AHCYL1 , TBC1D4 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , PRKCB , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , EIF2AK2 , LMNB1 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , BRCA1 , CASP2 , TNNT2 , CSNK1E , CDK9 , CASP9 , PPP1CA , GAD2 , PTK2 , PRKCD , STK4 , STK3 , IKZF1 , CAMK2G , POLD3 , PRKD1 , PARD3 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , SF3B1 , POLR2A , RYR2 , SRSF1 , SLC6A3 , SENP3 , Non-protein substrates of this phosphatase are not reported yet PPP1CB P62140 AURKA , AXIN1 , AHCYL1 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , CASP2 , TNNT2 , CSNK1E , GAD2 , PTK2 , PRKCD , STK4 , STK3 , IKZF1 , CAMK2G , POLD3 , PRKD1 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , POLR2A , RYR2 , CDC5L , Non-protein substrates of this phosphatase are not reported yet PTPN11 Q06124 SPRY2 , SPRY1 , JAK2 , MPZL1 , EGFR , PDGFRB , SRC , SELE , IRS1 , KDR , STAT1 , STAT5A , PXN , STAT5B , SIRPA , ARHGAP5 , GAB1 , PTK2B , PAG1 , GAB2 , MAP3K4 , ERBB2 , LCK , CD28 , ERBB2 , PDCD1 , ERBB4 , Non-protein substrates of this phosphatase are not reported yet G6PC3 Q9BUM1 Protein substrates of this phosphatase are not reported yet alpha-D-glucose 6-phosphate , beta-D-glucose 6-phosphate , G6PC2 Q9NQR9 Protein substrates of this phosphatase are not reported yet alpha-D-glucose 6-phosphate , beta-D-glucose 6-phosphate ,
Name UniProt AC Dephosphorylated by: IKBKB O14920 PPP2CA , PPP2CB , PPM1A , PPM1B , PPM1M , TBC1D4 O60343 PPP1CA , PRKCB P05771 PHLPP1 , PHLPP2 , PPP1CA , PPP2CA , PPP2CB , INSR P06213 PTPRF , ACP1 , PTPN1 , PTPRE , PTPN2 , DUSP3 , PTPRF P10586 PTPRF , GYS1 P13807 ALPP , CREB1 P16220 PPP2CA , PPP2CB , PTEN , CD36 P16671 ALPI , PTPN1 P18031 PTPN1 , RPS6KB1 P23443 PPP2CA , PPP2CB , PHLPP1 , PHLPP2 , NFKBIA P25963 PTPN1 , PTPN13 , PPP3CB , PPP3CC , PPP2CB , PPP2CA , PPP3CA , PIK3R1 P27986 PPM1A , PTPRJ , NOS3 P29474 PPP1CA , PPP1CB , PPP1CC , AKT1 P31749 ACP1 , PHLPP1 , PHLPP2 , PPP2CA , PPP2CB , PPP1CA , PPP1CB , PPP1CC , CTDSP1 , AKT2 P31751 PHLPP1 , PHLPP2 , IRS1 P35568 PTPN1 , PTPN13 , PTPN11 , PPP1CA , PPP1CB , PPP1CC , STAT3 P40763 DUSP22 , PTPN1 , PTPRD , PTPRT , PTPN2 , MAPK8 P45983 DUSP22 , DUSP8 , DUSP18 , DUSP1 , DUSP9 , DUSP10 , PPP2CA , PPP2CB , DUSP3 , MAPK9 P45984 DUSP19 , DUSP1 , DUSP4 , DUSP9 , DUSP10 , DUSP16 , DUSP3 , DUSP14 , GSK3B P49841 EPM2A , PPP3CA , PPP3CB , PPP3CC , PTPN1 , RPS6KA3 P51812 PPP2CA , PPP2CB , PPM1D , MAPK10 P53779 DUSP16 , PTEN P60484 PTEN , PPP2CA , PPP1CA P62136 PPP1CA , RELA Q04206 PPP2CA , PPP4C , PPP2CB , PRKCD Q05655 PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPM1A , PTPN11 Q06124 PTPN1 , PRKAA1 Q13131 PPP2CA , PPP2CB , RPS6KA1 Q15418 PPP2CA , PPP2CB , AKT3 Q9Y243 PHLPP1 , PHLPP2 , PPP2CA , PPP2CB ,
ChEBI ID KEGG ID ChEBIasciiName Molecule Dephosphorylated by: CHEBI:15946 C00085 keto-D-fructose 6-phosphate MDP1 , CHEBI:61553 C00085 D-fructofuranose 6-phosphate MDP1 , CHEBI:16618 C05981 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate TNS2 , FIG4 , INPP5B , INPP5E , INPP5K , OCRL , PTEN , PTPRQ , INPP5F , INPP5D , INPPL1 , SYNJ1 , SYNJ2 , TPTE2 ,
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