Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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TRPV6
Gene Name  | TRPV6 (QuickGO) | (A quick tutorial to explore the interctive visulaization) Representative structure: 6BO9 |
| Synonyms | TRPV6, ECAC2 | |
| Protein Name | TRPV6 | |
| Alternative Name(s) | Transient receptor potential cation channel subfamily V member 6;TrpV6;CaT-like;CaT-L;Calcium transport protein 1;CaT1;Epithelial calcium channel 2;ECaC2; | |
| Protein Family | Belongs to the transient receptor (TC 1A4) familyTrpV subfamily TRPV6 sub-subfamily | |
| EntrezGene ID | 55503 (Comparitive Toxicogenomics) | |
| UniProt AC (Human) | Q9H1D0 (protein sequence) | |
| Enzyme Class | N/A | |
| Molecular Weight | 87286 Dalton | |
| Protein Length | 765 amino acids (AA) | |
| Genome Browsers | NCBI | ENSG00000165125 (Ensembl) | UCSC | |
| Crosslinking annotations | Query our ID-mapping table | |
| Orthologues | Quest For Orthologues (QFO) | GeneTree | eggNOG - KOG3676 | eggNOG - ENOG4110DG4 | |
| Phosphorylation Network | Visualize | |
| Domain organization, Expression, Diseases | (show / hide) |
| Protein Domain | InterPro | Pfam | SMART | 3D Structure | PDB | DrugPort | ModBase | SwissModel |
| Polypeptide organization (Pfam)  | |||
| Gene Expression | Gene Expression Atlas | Disease | OMIM | DisGeNet | ClinVar |
| Protein-protein interactions | STRING | IntAct | MINT | BioGRID | ||
| Phosphosites | Phospho.ELM | PhosphoSitePlus |
| Localization, Function, Catalytic activity and Sequence | (show / hide) |
| Localization (UniProt annotation) | |||
| Cell membrane | |||
| Function (UniProt annotation) | |||
| Calcium selective cation channel that mediates Ca(2+)uptake in various tissues, including the intestine(PubMed:11097838, PubMed:11278579, PubMed:11248124PubMed:15184369, PubMed:23612980, PubMed:29258289) Important fornormal Ca(2+) ion homeostasis in the body, including bone and skin(By similarity) The channel is activated by low internal calciumlevel, probably including intracellular calcium store depletion,and the current exhibits an inward rectification(PubMed:15184369) Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; thelatter may be regulated by phosphorylation In vitro, is slowlyinhibited by Mg(2+) in a voltage-independent manner Heteromericassembly with TRPV5 seems to modify channel properties TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependentgating | |||
| Catalytic Activity (UniProt annotation) | |||
| N/A | |||
| Protein Sequence | |||
| MGPLQGDGGPALGGADVAPRLSPVRVWPRPQAPKEPALHPMGLSLPKEKGLILCLWSKFCRWFQRRESWAQSRDEQNLLQ QKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTA LHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVL HILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDL TEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRT SPRDNTLLQQKLLQEAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTILGGPFHVLIITYAFMVLVTM VMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEEL GHFYDYPMALFSTFELFLTIIDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVAT TVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLDKDSVEKLELGCPFSPHLSLP MPSVSRSTSRSSANWERLRQGTLRRDLRGIINRGLEDGESWEYQI | |||
| Motif information from Eukaryotic Linear Motif atlas (ELM) | (show / hide) |
| ELM Motif | Motif Instance
| Description | Motif Regex |
| NA | NA | NA | NA |
| Gene Ontology (P: Process; F: Function and C: Component terms) | (show / hide) | |
| GO:0005262 | F:calcium channel activity |
| GO:0005516 | F:calmodulin binding |
| GO:0005886 | C:plasma membrane |
| GO:0005887 | C:integral component of plasma membrane |
| GO:0006816 | P:calcium ion transport |
| GO:0017158 | P:regulation of calcium ion-dependent exocytosis |
| GO:0046872 | F:metal ion binding |
| GO:0051592 | P:response to calcium ion |
| GO:0055074 | P:calcium ion homeostasis |
| GO:0070588 | P:calcium ion transmembrane transport |
| GO:0098703 | P:calcium ion import across plasma membrane |
