Top LPP
Localization (UniProt annotation) Nucleus Cytoplasm Cell junction Cellmembrane Note=Found in the nucleus, in the cytoplasm and at celladhesion sites Shuttles between the cytoplasm and the nucleus Ithas been found in sites of cell adhesion such as cell-to-cellcontact and focal adhesion which are membrane attachment sites ofcells to the extracellular matrix Mainly nuclear when fused withHMGA2/HMGIC and KMT2A/MLL1 Function (UniProt annotation) May play a structural role at sites of cell adhesion inmaintaining cell shape and motility In addition to thesestructural functions, it may also be implicated in signalingevents and activation of gene transcription May be involved insignal transduction from cell adhesion sites to the nucleusallowing successful integration of signals arising from solublefactors and cell-cell adhesion sites Also suggested to serve as ascaffold protein upon which distinct protein complexes areassembled in the cytoplasm and in the nucleus{ECO:0000269|PubMed:10637295, ECO:0000269|Ref2} Catalytic Activity (UniProt annotation) N/A Protein Sequence MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSA
LPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTG
HKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSS
GQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQ
GHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKM
LYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCS
KPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDR
DFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL
ELM Motif Motif Instance Description Motif Regex NA NA NA NA
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ALAD Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID ARPC3 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID ARPC4 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID ATP5MF Two-hybrid physical 16169070 , (Europe PMC )NA BioGRID CALR Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID CBLC Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CDH1 Proximity Label-MS physical 25468996 , (Europe PMC )NA BioGRID CLNS1A Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID COPS5 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CPT1A Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID DBNL Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID DPP9 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID EFL1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID EGLN2 Affinity Capture-Western physical 22286099 , (Europe PMC )NA BioGRID ELAVL1 Affinity Capture-RNA physical 19322201 , (Europe PMC )NA BioGRID FEN1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID FKBP10 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID G3BP1 Affinity Capture-MS physical 26777405 , (Europe PMC )NA BioGRID GMPPA Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HNRNPL Affinity Capture-RNA, Co-fractionation physical 22939629 , 28611215 , (Europe PMC )NA BioGRID HSPA5 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID HSPBP1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID IPO11 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID LPXN Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MRPL38 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MTNR1A Two-hybrid, ubiquitin reconstruction physical, physical association 26514267 , (Europe PMC )0.37 BioGRID, IntAct NIF3L1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID NINL Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct NPLOC4 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID OGT Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID P3H1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PDLIM7 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PICALM Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PNPO Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PPME1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PPP2R1A Affinity Capture-MS, anti tag coimmunoprecipitation, pull down association, physical 19156129 , 26496610 , 28330616 , (Europe PMC )0.53 BioGRID, IntAct PPP2R3A Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PPP2R5D Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PTPN21 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID RANGAP1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID RDX Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID RNF2 Affinity Capture-MS physical 24457600 , (Europe PMC )NA BioGRID RPRD1B Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID SAE1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID SERPINB2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID SH3GLB1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID SURF2 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID SUZ12 Affinity Capture-MS physical 24457600 , (Europe PMC )NA BioGRID TES Affinity Capture-MS physical 28378594 , (Europe PMC )NA BioGRID TPRKB Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID UBE3A Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID UFM1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID VHL Affinity Capture-Western physical 22286099 , (Europe PMC )NA BioGRID WASF3 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID WDYHV1 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID XPO1 Affinity Capture-MS physical 26673895 , (Europe PMC )NA BioGRID ZPR1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ATRAID two hybrid pooling approach physical association 16169070 , (Europe PMC )0.37 IntAct LASP1 proximity ligation assay, pull down association, physical association 22665060 , (Europe PMC )0.50 IntAct MTNR1A Two-hybrid, ubiquitin reconstruction physical, physical association 26514267 , (Europe PMC )0.37 BioGRID, IntAct NINL Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct PPP2R1A Affinity Capture-MS, anti tag coimmunoprecipitation, pull down association, physical 19156129 , 26496610 , 28330616 , (Europe PMC )0.53 BioGRID, IntAct SHPRH two hybrid pooling approach physical association 16169070 , (Europe PMC )0.37 IntAct TJP2 far western blotting association 22665060 , (Europe PMC )0.35 IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ALAD Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID ARPC3 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID ARPC4 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID ATP5J2 two hybrid pooling approach physical association 16169070 , (Europe PMC )0.37 IntAct ATP5MF Two-hybrid physical 16169070 , (Europe PMC )NA BioGRID ATRAID two hybrid pooling approach physical association 16169070 , (Europe PMC )0.37 IntAct CALR Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID CBLC Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CDH1 Proximity Label-MS physical 25468996 , (Europe PMC )NA BioGRID CLNS1A Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID COPS5 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CPT1A Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID DBNL Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID DPP9 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID EFL1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID EGLN2 Affinity Capture-Western physical 22286099 , (Europe PMC )NA BioGRID ELAVL1 Affinity Capture-RNA physical 19322201 , (Europe PMC )NA BioGRID FEN1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID FKBP10 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID G3BP1 Affinity Capture-MS physical 26777405 , (Europe PMC )NA BioGRID GMPPA Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HNRNPL Affinity Capture-RNA, Co-fractionation physical 22939629 , 28611215 , (Europe PMC )NA BioGRID HSPA5 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID HSPBP1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID IPO11 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID LASP1 proximity ligation assay, pull down association, physical association 22665060 , (Europe PMC )0.50 IntAct LPXN Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MRPL38 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MTNR1A Two-hybrid, ubiquitin reconstruction physical, physical association 26514267 , (Europe PMC )0.37 BioGRID, IntAct NIF3L1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID NINL Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct NPLOC4 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID OGT Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID P3H1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PDLIM7 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PICALM Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PNPO Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PPME1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PPP2R1A Affinity Capture-MS, anti tag coimmunoprecipitation, pull down association, physical 19156129 , 26496610 , 28330616 , (Europe PMC )0.53 BioGRID, IntAct PPP2R3A Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PPP2R5D Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PTPN21 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID RANGAP1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID RDX Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID RNF2 Affinity Capture-MS physical 24457600 , (Europe PMC )NA BioGRID RPRD1B Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID SAE1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID SERPINB2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID SH3GLB1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID SHPRH two hybrid pooling approach physical association 16169070 , (Europe PMC )0.37 IntAct SURF2 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID SUZ12 Affinity Capture-MS physical 24457600 , (Europe PMC )NA BioGRID TES Affinity Capture-MS physical 28378594 , (Europe PMC )NA BioGRID TJP2 far western blotting association 22665060 , (Europe PMC )0.35 IntAct TPRKB Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID UBE3A Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID UFM1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID VHL Affinity Capture-Western physical 22286099 , (Europe PMC )NA BioGRID WASF3 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID WDYHV1 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID XPO1 Affinity Capture-MS physical 26673895 , (Europe PMC )NA BioGRID ZPR1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID
Phosphorylating Kinases Phosphoresidues Detection Method PubMed IDs Source
Visualize a network of protein kinases and phosphatases phosphorylating and dephosphorylating this protein respectively
SRC Y244_APSSGQIyGSGPQGY , Y300_QGRYYEGyYAAGPGY , Y301_GRYYEGYyAAGPGYG , NA NA PhosphoSitePlus , Unknown S115_KTLEERRsSLDAEID , S116_TLEERRSsLDAEIDS , S135_LADLECSsPYKPRPP , S144_YKPRPPQsSTGSTAS , T333_WKREPGYtPPGAGNQ , Y297_APNQGRYyEGYYAAG , Y300_QGRYYEGyYAAGPGY , Y301_GRYYEGYyAAGPGYG , Y317_RNDSDPTyGQQGHPN , HTP, in vitro, in vivo 12522270 , 15144186 , 15592455 , 15659558 , 16094384 , 17016520 , 17081983 , 18083107 , 18669648 , 20068231 ,(Europe PMC )HPRD, PhosphoELM ,
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