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KEGG Pathway - Focal adhesion - Homo sapiens (human) Name UniProt AC Dephosphorylates following protein substrates: Dephosphorylates following non-protein substrates: PPP1CC P36873 FXYD1 , AURKA , AXIN1 , AHCYL1 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , CASP2 , TNNT2 , CSNK1E , HIST1H3A , CENPE , GAD2 , PTK2 , PRKCD , STK4 , STK3 , ATM , IKZF1 , CAMK2G , POLD3 , PRKD1 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , POLR2A , TTK , RYR2 , Non-protein substrates of this phosphatase are not reported yet PTEN P60484 PDGFRB , CREB1 , SHC1 , PTEN , PTK2 , PTK6 , 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate , 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate , 1D-myo-inositol 1,3,4,5-tetrakisphosphate , 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate , 1-phosphatidyl-1D-myo-inositol 3-phosphate , PPP1CA P62136 AURKA , AXIN1 , AHCYL1 , TBC1D4 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , PRKCB , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , EIF2AK2 , LMNB1 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , BRCA1 , CASP2 , TNNT2 , CSNK1E , CDK9 , CASP9 , PPP1CA , GAD2 , PTK2 , PRKCD , STK4 , STK3 , IKZF1 , CAMK2G , POLD3 , PRKD1 , PARD3 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , SF3B1 , POLR2A , RYR2 , SRSF1 , SLC6A3 , SENP3 , Non-protein substrates of this phosphatase are not reported yet PPP1CB P62140 AURKA , AXIN1 , AHCYL1 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , CASP2 , TNNT2 , CSNK1E , GAD2 , PTK2 , PRKCD , STK4 , STK3 , IKZF1 , CAMK2G , POLD3 , PRKD1 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , POLR2A , RYR2 , CDC5L , Non-protein substrates of this phosphatase are not reported yet
Name UniProt AC Dephosphorylated by: EGFR P00533 CDC25A , ACP1 , PTPN1 , PTPN9 , PTPRU , PTPRJ , PTPRK , PTPRS , PTPN6 , PTPN11 , PTPN2 , DUSP3 , UBASH3B , PTPRA , PTPRB , PTPN12 , PTPRH , RAF1 P04049 CDC25A , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPP5C , PTPN1 , ERBB2 P04626 ACPP , PTPN9 , DUSP3 , PTPN6 , PTPN12 , PTPN11 , PTPN18 , PTPN11 , JUN P05412 PPP3CA , PPP3CB , PPP3CC , ITGB1 P05556 PPP2CA , PPP2CB , PTP4A3 , PRKCB P05771 PHLPP1 , PHLPP2 , PPP1CA , PPP2CA , PPP2CB , FYN P06241 PTPRC , PTPN18 , PTPRA , PTPRE , PTPRJ , PTPN5 , IGF1R P08069 PTPN1 , MET P08581 PTPRF , PTPN1 , PTPRB , PTPRJ , PTPN2 , PDGFRB P09619 ACP1 , PTEN , PTPN1 , PTPRJ , PTPN11 , PTPN2 , DUSP3 , BCL2 P10415 PPP2CA , PPP2CB , ACTN1 P12814 PTPN1 , PTPN6 , SRC P12931 PTPN23 , ACP1 , PPP2CA , PPP2CB , PTPN1 , PTPN21 , PTPN12 , PTPRA , PTPRE , PTPRJ , PTPRH , PTPN6 , PTPN11 , PTPN2 , PRKCA P17252 PHLPP1 , PHLPP2 , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , ELK1 P19419 PPP3CA , PPP3CB , PPP3CC , FLNA P21333 PPP3CA , PPP3CB , PPP3CC , MAPK3 P27361 CDC25A , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP9 , DUSP23 , PTPRE , PTPRJ , DUSP3 , PPP2CA , PTPRR , DUSP14 , PIK3R1 P27986 PPM1A , PTPRJ , MAPK1 P28482 CDC25A , DUSP22 , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP6 , DUSP9 , DUSP7 , DUSP2 , PPP2CA , PPP2CB , PTPRE , PTPRJ , DUSP3 , PTPRR , SHC1 P29353 PTEN , PTPN2 , AKT1 P31749 ACP1 , PHLPP1 , PHLPP2 , PPP2CA , PPP2CB , PPP1CA , PPP1CB , PPP1CC , CTDSP1 , AKT2 P31751 PHLPP1 , PHLPP2 , CTNNB1 P35222 PTPN23 , PTPRF , ACP1 , PTPN14 , PTPN1 , PTPRU , PTPRK , DUSP23 , KDR P35968 ACP1 , PTPRB , PTPRJ , PTPN6 , PTPN11 , PTPN2 , MAPK8 P45983 DUSP22 , DUSP8 , DUSP18 , DUSP1 , DUSP9 , DUSP10 , PPP2CA , PPP2CB , DUSP3 , MAPK9 P45984 DUSP19 , DUSP1 , DUSP4 , DUSP9 , DUSP10 , DUSP16 , DUSP3 , DUSP14 , CRK P46108 PTPN1 , PXN P49023 PPP2CA , PPP2CB , PTPRT , PTPN11 , GSK3B P49841 EPM2A , PPP3CA , PPP3CB , PPP3CC , PTPN1 , VASP P50552 PPP2CA , PPP2CB , PPP3CA , PPP3CB , PPP3CC , MAPK10 P53779 DUSP16 , BCAR1 P56945 PPP2CA , PPP2CB , PTP4A3 , PTPN1 , PTPN12 , PTPRA , PTPRH , PTEN P60484 PTEN , PPP2CA , PPP1CA P62136 PPP1CA , MAP2K1 Q02750 PPP2CA , PPP2CB , CAV1 Q03135 PTPN1 , PTPN2 , PTK2 Q05397 PTPN23 , ACP1 , PPP1CA , PPP1CB , PPP1CC , PTEN , PTPN1 , PTPN12 , UBASH3B , ARHGAP5 Q13017 PTPN11 , PAK1 Q13153 PPM1F , PPM1E , PPP2CA , PPP2CB , PPM1A , PAK2 Q13177 PPM1A , BAD Q92934 ALPL , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPP3CA , PPP3CB , PPP3CC , PPM1B , PPP5C , ARHGAP35 Q9NRY4 PTPN18 , PTPRZ1 , AKT3 Q9Y243 PHLPP1 , PHLPP2 , PPP2CA , PPP2CB ,
ChEBI ID KEGG ID ChEBIasciiName Molecule Dephosphorylated by: CHEBI:18348 C04637 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate FIG4 , INPP5B , INPP5E , INPP5J , INPP5K , OCRL , PTP4A3 , PTPRQ , INPP5F , SYNJ1 , SYNJ2 , CHEBI:16618 C05981 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate TNS2 , FIG4 , INPP5B , INPP5E , INPP5K , OCRL , PTEN , PTPRQ , INPP5F , INPP5D , INPPL1 , SYNJ1 , SYNJ2 , TPTE2 ,
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