Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - T cell receptor signaling pathway - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| PTPRC | P08575 | JAK2, LCK, FYN, LYN, CD247, JAK1, TYK2, JAK3, SKAP1, CSK, | Non-protein substrates of this phosphatase are not reported yet |
| PPP3CB | P16298 | DNM1L, CRYAA, HSPB1, JUN, MAPT, NEFH, PRKAR2A, ELK1, FLNA, CANX, CSNK1E, GSK3B, VASP, DNM2, RCAN1, DNM1, GAD2, NFATC2, PPP1R1A, SLC10A1, KSR2, SSH1, BAD, GAD1, PPP1R1B, TFEB, NFKBIA, LASP1, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN6 | P29350 | JAK2, CTNND1, NFAT5, EGFR, ESR1, NTRK1, LCK, LYN, ROS1, KIT, ACTN1, SRC, CD33, CD22, NOS1, HOXA10, KDR, CASP8, GAB2, ERBB2, ERBB4, | Non-protein substrates of this phosphatase are not reported yet |
| PPP3CC | P48454 | DNM1L, CRYAA, HSPB1, JUN, MAPT, NEFH, PRKAR2A, ELK1, FLNA, CANX, CSNK1E, GSK3B, VASP, DNM2, RCAN1, DNM1, GAD2, NFATC2, PPP1R1A, SLC10A1, KSR2, SSH1, BAD, GAD1, PPP1R1B, TFEB, NFKBIA, LASP1, | Non-protein substrates of this phosphatase are not reported yet |
| PPP3CA | Q08209 | DNM1L, CRYAA, HSPB1, JUN, MAPT, NEFH, PRKAR2A, ELK1, FLNA, CANX, CSNK1E, GSK3B, VASP, DNM2, RCAN1, DNM1, GAD2, NFATC2, PPP1R1A, SLC10A1, KSR2, SSH1, BAD, GAD1, PPP1R1B, TFEB, NFKBIA, LASP1, TRPM3, ORAI1, | Non-protein substrates of this phosphatase are not reported yet |
| Protein substrates in this pathway |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:16595 | C01245 | 1D-myo-inositol 1,4,5-trisphosphate |  | INPP5B, INPP5A, INPP5E, INPP5J, INPP5K, OCRL, SYNJ1, SYNJ2, |
| CHEBI:16618 | C05981 | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate |  | TNS2, FIG4, INPP5B, INPP5E, INPP5K, OCRL, PTEN, PTPRQ, INPP5F, INPP5D, INPPL1, SYNJ1, SYNJ2, TPTE2, |