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PHPT1
Localization (UniProt annotation) Cytoplasm Function (UniProt annotation) Exhibits phosphohistidine phosphatase activity Catalytic Activity (UniProt annotation) A [protein]-N-phospho-L-histidine + H(2)O = a[protein]-L-histidine + phosphate Protein Sequence MAVADLALIPDVDIDSDGVFKYVLIRVHSAPRSGAPAAESKEIVRGYKWAEYHADIYDKVSGDMQKQGCDCECLGGGRIS
HQSQDKKIHVYGYSMAYGPAQHAISTEKIKAKYPDYEVTWANDGY
ELM Motif Motif Instance Description Motif Regex NA NA NA NA
GO:0005829 C:cytosol GO:0006470 P:protein dephosphorylation GO:0019855 F:calcium channel inhibitor activity GO:0035774 P:positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035971 P:peptidyl-histidine dephosphorylation GO:0044325 F:ion channel binding GO:0050860 P:negative regulation of T cell receptor signaling pathway GO:0051350 P:negative regulation of lyase activity GO:0070062 C:extracellular exosome GO:0101006 F:protein histidine phosphatase activity GO:2000147 P:positive regulation of cell motility GO:2000249 P:regulation of actin cytoskeleton reorganization GO:2000984 P:negative regulation of ATP citrate synthase activity
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ATXN1L Two-hybrid physical 16713569 , (Europe PMC )NA BioGRID DNMT3L Two-hybrid, two hybrid pooling approach physical, physical association 16189514 , (Europe PMC )0.37 BioGRID, IntAct GDPGP1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID GTF2E2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID IGBP1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID IMPA1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID NUDT9 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PLPBP Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PPP1R16A Two-hybrid physical 16169070 , (Europe PMC )NA BioGRID PSME1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PTMS Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PTPA Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID RAB1A Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID RANBP3 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID RBKS Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TINF2 Two-hybrid, bimolecular fluorescence complementation physical, physical association 21044950 , (Europe PMC )0.37 BioGRID, IntAct TRAPPC4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID UBC Reconstituted Complex physical 28190767 , (Europe PMC )NA BioGRID ZPR1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source DNMT3L Two-hybrid, two hybrid pooling approach physical, physical association 16189514 , (Europe PMC )0.37 BioGRID, IntAct KCNN4 anti tag coimmunoprecipitation physical association 18796614 , (Europe PMC )0.40 IntAct TINF2 Two-hybrid, bimolecular fluorescence complementation physical, physical association 21044950 , (Europe PMC )0.37 BioGRID, IntAct TPM4 pull down physical association 28330616 , (Europe PMC )0.40 IntAct TRAF6 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ATXN1L Two-hybrid physical 16713569 , (Europe PMC )NA BioGRID DNMT3L Two-hybrid, two hybrid pooling approach physical, physical association 16189514 , (Europe PMC )0.37 BioGRID, IntAct GDPGP1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID GTF2E2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID IGBP1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID IMPA1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID KCNN4 anti tag coimmunoprecipitation physical association 18796614 , (Europe PMC )0.40 IntAct NUDT9 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PLPBP Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PPP1R16A Two-hybrid physical 16169070 , (Europe PMC )NA BioGRID PSME1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PTMS Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PTPA Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID RAB1A Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID RANBP3 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID RBKS Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TINF2 Two-hybrid, bimolecular fluorescence complementation physical, physical association 21044950 , (Europe PMC )0.37 BioGRID, IntAct TPM4 pull down physical association 28330616 , (Europe PMC )0.40 IntAct TRAF6 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct TRAPPC4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID UBC Reconstituted Complex physical 28190767 , (Europe PMC )NA BioGRID ZPR1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID