Top ACP1
Localization (UniProt annotation) Cytoplasm Function (UniProt annotation) Acts on tyrosine phosphorylated proteins, low-MW arylphosphates and natural and synthetic acyl phosphates Isoform 3does not possess phosphatase activity Catalytic Activity (UniProt annotation) Protein tyrosine phosphate + H(2)O = proteintyrosine + phosphate A phosphate monoester + H(2)O = an alcohol +phosphate Protein Sequence MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITK
EDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
ELM Motif Motif Instance Description Motif Regex NA NA NA NA
Pathway ID Pathway Name Pathway Description (KEGG) hsa00730 Thiamine metabolism hsa00740 Riboflavin metabolism hsa01100 Metabolic pathways hsa04520 Adherens junction Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ACP1 Affinity Capture-MS, anti bait coimmunoprecipitation physical, physical association 17353931 , 27432908 , (Europe PMC )0.40 BioGRID, IntAct ACTB Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ACTBL2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ADA Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID BARD1 Two-hybrid physical 22990118 , (Europe PMC )NA BioGRID CDK2 Affinity Capture-MS physical 21319273 , (Europe PMC )NA BioGRID COPS5 Affinity Capture-MS physical 21145461 , (Europe PMC )NA BioGRID CTNNB1 Co-localization physical 12438242 , (Europe PMC )NA BioGRID DLD Affinity Capture-MS, cross-linking study association, physical 29128334 , (Europe PMC )0.35 BioGRID, IntAct DNAJC13 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP12 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP28 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID EGFR Affinity Capture-MS physical 24797263 , (Europe PMC )NA BioGRID EPHA2 Affinity Capture-Western, Biochemical Activity physical 12167657 , (Europe PMC )NA BioGRID EPHB1 Affinity Capture-Western, Reconstituted Complex physical 9499402 , (Europe PMC )NA BioGRID EPHB2 Affinity Capture-Western physical 9499402 , (Europe PMC )NA BioGRID FN1 Affinity Capture-MS physical 19738201 , (Europe PMC )NA BioGRID FNBP1L Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct GADD45GIP1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID GOT1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID INSR Affinity Capture-Western physical 9299573 , (Europe PMC )NA BioGRID ITGA4 Affinity Capture-MS physical 22623428 , (Europe PMC )NA BioGRID KDR Two-hybrid physical 10608891 , (Europe PMC )NA BioGRID KEAP1 Affinity Capture-MS physical 27621311 , (Europe PMC )NA BioGRID MCM2 Affinity Capture-MS physical 25963833 , (Europe PMC )NA BioGRID MRPL20 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct PCBP1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PITPNA Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID POTEE Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PPIL3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID RPL12 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SFMBT1 Two-hybrid, two hybrid pooling approach physical, physical association 16189514 , (Europe PMC )0.37 BioGRID, IntAct TALDO1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TES Affinity Capture-MS physical 28378594 , (Europe PMC )NA BioGRID TKT Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TKTL2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID VCAM1 Affinity Capture-MS, cross-linking study association, physical 19738201 , 22623428 , (Europe PMC )0.35 BioGRID, IntAct ZAP70 Affinity Capture-Western physical 11976341 , (Europe PMC )NA BioGRID ZBTB43 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source DLD Affinity Capture-MS, cross-linking study association, physical 29128334 , (Europe PMC )0.35 BioGRID, IntAct EIF1B anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct EIF6 {ECO:0000255|HAMAP-Rule:MF_03132, anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct EPB41 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct FNBP1L Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct IKBKE anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct KSR1 anti tag coimmunoprecipitation association 27086506 , (Europe PMC )0.35 IntAct MRPL20 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct NR3C1 display technology physical association 20195357 , (Europe PMC )0.40 IntAct PAK2 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct SFMBT1 Two-hybrid, two hybrid pooling approach physical, physical association 16189514 , (Europe PMC )0.37 BioGRID, IntAct TNIK anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct VCAM1 Affinity Capture-MS, cross-linking study association, physical 19738201 , 22623428 , (Europe PMC )0.35 BioGRID, IntAct VHL anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ACP1 Affinity Capture-MS, anti bait coimmunoprecipitation physical, physical association 17353931 , 27432908 , (Europe PMC )0.40 BioGRID, IntAct ACTB Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ACTBL2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ADA Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID BARD1 Two-hybrid physical 22990118 , (Europe PMC )NA BioGRID CDK2 Affinity Capture-MS physical 21319273 , (Europe PMC )NA BioGRID COPS5 Affinity Capture-MS physical 21145461 , (Europe PMC )NA BioGRID CTNNB1 Co-localization physical 12438242 , (Europe PMC )NA BioGRID DLD Affinity Capture-MS, cross-linking study association, physical 29128334 , (Europe PMC )0.35 BioGRID, IntAct DNAJC13 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP12 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP28 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID EGFR Affinity Capture-MS physical 24797263 , (Europe PMC )NA BioGRID EIF1B anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct EIF6 {ECO:0000255|HAMAP-Rule:MF_03132, anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct EPB41 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct EPHA2 Affinity Capture-Western, Biochemical Activity physical 12167657 , (Europe PMC )NA BioGRID EPHB1 Affinity Capture-Western, Reconstituted Complex physical 9499402 , (Europe PMC )NA BioGRID EPHB2 Affinity Capture-Western physical 9499402 , (Europe PMC )NA BioGRID FN1 Affinity Capture-MS physical 19738201 , (Europe PMC )NA BioGRID FNBP1L Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct GADD45GIP1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID GOT1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID IKBKE anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct INSR Affinity Capture-Western physical 9299573 , (Europe PMC )NA BioGRID ITGA4 Affinity Capture-MS physical 22623428 , (Europe PMC )NA BioGRID KDR Two-hybrid physical 10608891 , (Europe PMC )NA BioGRID KEAP1 Affinity Capture-MS physical 27621311 , (Europe PMC )NA BioGRID KSR1 anti tag coimmunoprecipitation association 27086506 , (Europe PMC )0.35 IntAct MCM2 Affinity Capture-MS physical 25963833 , (Europe PMC )NA BioGRID MRPL20 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct NR3C1 display technology physical association 20195357 , (Europe PMC )0.40 IntAct PAK2 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct PCBP1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PITPNA Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID POTEE Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PPIL3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID RPL12 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SFMBT1 Two-hybrid, two hybrid pooling approach physical, physical association 16189514 , (Europe PMC )0.37 BioGRID, IntAct TALDO1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TES Affinity Capture-MS physical 28378594 , (Europe PMC )NA BioGRID TKT Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TKTL2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TNIK anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct VCAM1 Affinity Capture-MS, cross-linking study association, physical 19738201 , 22623428 , (Europe PMC )0.35 BioGRID, IntAct VHL anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct ZAP70 Affinity Capture-Western physical 11976341 , (Europe PMC )NA BioGRID ZBTB43 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID
Phosphorylating Kinases Phosphoresidues Detection Method PubMed IDs Source
Visualize a network of protein kinases and phosphatases phosphorylating and dephosphorylating this protein respectively
FYN Y132_QLIIEDPyYGNDSDF , Y133_LIIEDPYyGNDSDFE , in vitro, in vivo 17016520 , 9038134 ,(Europe PMC )HPRD, LCK Y132_QLIIEDPyYGNDSDF , Y133_LIIEDPYyGNDSDFE , in vitro, in vivo 17016520 , 9038134 ,(Europe PMC )HPRD, PhosphoSitePlus , Unknown S20_CLGNICRsPIAEAVF , T32_AVFRKLVtDQNISEN , Y132_QLIIEDPyYGNDSDF , HTP, in vivo 15951569 , 17016520 , 18083107 , 20068231 ,(Europe PMC )HPRD, PhosphoELM ,
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