Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - Calcium signaling pathway - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| PPP3CB | P16298 | DNM1L, CRYAA, HSPB1, JUN, MAPT, NEFH, PRKAR2A, ELK1, FLNA, CANX, CSNK1E, GSK3B, VASP, DNM2, RCAN1, DNM1, GAD2, NFATC2, PPP1R1A, SLC10A1, KSR2, SSH1, BAD, GAD1, PPP1R1B, TFEB, NFKBIA, LASP1, | Non-protein substrates of this phosphatase are not reported yet |
| PPP3CC | P48454 | DNM1L, CRYAA, HSPB1, JUN, MAPT, NEFH, PRKAR2A, ELK1, FLNA, CANX, CSNK1E, GSK3B, VASP, DNM2, RCAN1, DNM1, GAD2, NFATC2, PPP1R1A, SLC10A1, KSR2, SSH1, BAD, GAD1, PPP1R1B, TFEB, NFKBIA, LASP1, | Non-protein substrates of this phosphatase are not reported yet |
| PPP3CA | Q08209 | DNM1L, CRYAA, HSPB1, JUN, MAPT, NEFH, PRKAR2A, ELK1, FLNA, CANX, CSNK1E, GSK3B, VASP, DNM2, RCAN1, DNM1, GAD2, NFATC2, PPP1R1A, SLC10A1, KSR2, SSH1, BAD, GAD1, PPP1R1B, TFEB, NFKBIA, LASP1, TRPM3, ORAI1, | Non-protein substrates of this phosphatase are not reported yet |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| EGFR | P00533 | CDC25A, ACP1, PTPN1, PTPN9, PTPRU, PTPRJ, PTPRK, PTPRS, PTPN6, PTPN11, PTPN2, DUSP3, UBASH3B, PTPRA, PTPRB, PTPN12, PTPRH, |
| ERBB2 | P04626 | ACPP, PTPN9, DUSP3, PTPN6, PTPN12, PTPN11, PTPN18, PTPN11, |
| PRKCB | P05771 | PHLPP1, PHLPP2, PPP1CA, PPP2CA, PPP2CB, |
| PDGFRB | P09619 | ACP1, PTEN, PTPN1, PTPRJ, PTPN11, PTPN2, DUSP3, |
| PRKCA | P17252 | PHLPP1, PHLPP2, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, |
| PRKACA | P17612 | PPP2CA, PPP2CB, |
| PLCG1 | P19174 | PTPN1, PTPRJ, |
| RYR1 | P21817 | PPP1CA, PPP1CB, PPP1CC, |
| NOS3 | P29474 | PPP1CA, PPP1CB, PPP1CC, |
| NOS1 | P29475 | PTPN6, |
| CAMK2B | Q13554 | PPP2CA, PPP2CB, |
| CAMK2G | Q13555 | PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, CTDSPL, |
| PTK2B | Q14289 | PTPN12, PTPN11, |
| ERBB4 | Q15303 | ACP4, PTPN6, PTPN11, |
| CAMK4 | Q16566 | PPM1F, PPM1E, PPP2CA, PPP2CB, |
| SPHK1 | Q9NYA1 | PPP2CA, PPP2CB, |
| CAMK2A | Q9UQM7 | PPM1F, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, |
| RYR2 | Q92736 | PPP1CC, PPP1CA, PPP1CB, PPP2CB, PPP2CA, |
| ORAI1 | Q96D31 | PPP3CA, |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:16595 | C01245 | 1D-myo-inositol 1,4,5-trisphosphate |  | INPP5B, INPP5A, INPP5E, INPP5J, INPP5K, OCRL, SYNJ1, SYNJ2, |
| CHEBI:37550 | C06124 | sphingosine 1-phosphate |  | PLPP1, PLPP3, PLPP2, SGPP1, SGPP2, |