Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - Purine metabolism - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| POLR2A | P24928 | CTDSPL2, EYA1, EYA3, CTDP1, RPAP2, CTDSP1, CTDSP2, SSU72, UBLCP1, PPP1CC, PPP1CA, PPP1CB, |
| POLD3 | Q15054 | PPP1CA, PPP1CB, PPP1CC, |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:16027 | C00020 | adenosine 5'-monophosphate |  | ACPP, ALPL, NT5E, NT5C1A, |
| CHEBI:17980 | C00053 | 3'-phospho-5'-adenylyl sulfate |  | BPNT1, |
| CHEBI:17985 | C00054 | adenosine 3',5'-bismonophosphate |  | BPNT1, |
| CHEBI:17797 | C00117 | aldehydo-D-ribose 5-phosphate |  | MDP1, |
| CHEBI:52742 | C00117 | D-ribofuranose 5-phosphate | | MDP1, |
| CHEBI:17202 | C00130 | IMP |  | NT5E, NT5C1A, NT5C2, NT5C, |
| CHEBI:17345 | C00144 | guanosine 5'-monophosphate |  | NT5E, NT5C1A, NT5C2, NT5C, |
| CHEBI:17713 | C00360 | 2'-deoxyadenosine 5'-monophosphate |  | NT5C1A, NT5C2, NT5C, |
| CHEBI:16192 | C00362 | 2'-deoxyguanosine 5'-monophosphate |  | NT5C1A, NT5C2, NT5C, |
| CHEBI:28806 | C06196 | 2'-deoxyinosine-5'-monophosphate |  | NT5C1A, NT5C2, NT5C, |