Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - Inflammatory mediator regulation of TRP channels - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| NTRK1 | P04629 | PTPRZ1, PTPRS, PTPN6, |
| PRKCB | P05771 | PHLPP1, PHLPP2, PPP1CA, PPP2CA, PPP2CB, |
| SRC | P12931 | PTPN23, ACP1, PPP2CA, PPP2CB, PTPN1, PTPN21, PTPN12, PTPRA, PTPRE, PTPRJ, PTPRH, PTPN6, PTPN11, PTPN2, |
| PRKCA | P17252 | PHLPP1, PHLPP2, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, |
| PRKACA | P17612 | PPP2CA, PPP2CB, |
| PLCG1 | P19174 | PTPN1, PTPRJ, |
| PIK3R1 | P27986 | PPM1A, PTPRJ, |
| MAPK8 | P45983 | DUSP22, DUSP8, DUSP18, DUSP1, DUSP9, DUSP10, PPP2CA, PPP2CB, DUSP3, |
| MAPK9 | P45984 | DUSP19, DUSP1, DUSP4, DUSP9, DUSP10, DUSP16, DUSP3, DUSP14, |
| MAP2K6 | P52564 | PPM1A, |
| MAPK12 | P53778 | PTPN3, |
| MAPK10 | P53779 | DUSP16, |
| PPP1CA | P62136 | PPP1CA, |
| PRKCD | Q05655 | PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPM1A, |
| CAMK2B | Q13554 | PPP2CA, PPP2CB, |
| CAMK2G | Q13555 | PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, CTDSPL, |
| MAPK14 | Q16539 | DUSP22, DUPD1, PTPN7, DUSP8, DUSP1, DUSP9, DUSP10, DUSP2, PPP2CA, PPP2CB, PPM1A, PPM1D, DUSP26, DUSP3, DUSP14, |
| CAMK2A | Q9UQM7 | PPM1F, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:16595 | C01245 | 1D-myo-inositol 1,4,5-trisphosphate |  | INPP5B, INPP5A, INPP5E, INPP5J, INPP5K, OCRL, SYNJ1, SYNJ2, |