Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - cGMP-PKG signaling pathway - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| RAF1 | P04049 | CDC25A, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPP5C, PTPN1, |
| INSR | P06213 | PTPRF, ACP1, PTPN1, PTPRE, PTPN2, DUSP3, |
| CREB1 | P16220 | PPP2CA, PPP2CB, PTEN, |
| MAPK3 | P27361 | CDC25A, DUPD1, PTPN7, DUSP5, DUSP1, DUSP4, DUSP9, DUSP23, PTPRE, PTPRJ, DUSP3, PPP2CA, PTPRR, DUSP14, |
| MAPK1 | P28482 | CDC25A, DUSP22, DUPD1, PTPN7, DUSP5, DUSP1, DUSP4, DUSP6, DUSP9, DUSP7, DUSP2, PPP2CA, PPP2CB, PTPRE, PTPRJ, DUSP3, PTPRR, |
| NOS3 | P29474 | PPP1CA, PPP1CB, PPP1CC, |
| AKT1 | P31749 | ACP1, PHLPP1, PHLPP2, PPP2CA, PPP2CB, PPP1CA, PPP1CB, PPP1CC, CTDSP1, |
| AKT2 | P31751 | PHLPP1, PHLPP2, |
| IRS1 | P35568 | PTPN1, PTPN13, PTPN11, PPP1CA, PPP1CB, PPP1CC, |
| VASP | P50552 | PPP2CA, PPP2CB, PPP3CA, PPP3CB, PPP3CC, |
| PPP1CA | P62136 | PPP1CA, |
| MAP2K1 | Q02750 | PPP2CA, PPP2CB, |
| NFATC2 | Q13469 | PPP3CA, PPP3CB, PPP3CC, |
| PRKG1 | Q13976 | PPP2CA, PPP2CB, |
| BAD | Q92934 | ALPL, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPP3CA, PPP3CB, PPP3CC, PPM1B, PPP5C, |
| AKT3 | Q9Y243 | PHLPP1, PHLPP2, PPP2CA, PPP2CB, |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:16027 | C00020 | adenosine 5'-monophosphate |  | ACPP, ALPL, NT5E, NT5C1A, |
| CHEBI:17345 | C00144 | guanosine 5'-monophosphate |  | NT5E, NT5C1A, NT5C2, NT5C, |
| CHEBI:16595 | C01245 | 1D-myo-inositol 1,4,5-trisphosphate |  | INPP5B, INPP5A, INPP5E, INPP5J, INPP5K, OCRL, SYNJ1, SYNJ2, |