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REACTOME Pathway - DARPP-32 events Name UniProt AC Dephosphorylates following protein substrates: Dephosphorylates following non-protein substrates: PPP3CB P16298 DNM1L , CRYAA , HSPB1 , JUN , MAPT , NEFH , PRKAR2A , ELK1 , FLNA , CANX , CSNK1E , GSK3B , VASP , DNM2 , RCAN1 , DNM1 , GAD2 , NFATC2 , PPP1R1A , SLC10A1 , KSR2 , SSH1 , BAD , GAD1 , PPP1R1B , TFEB , NFKBIA , LASP1 , Non-protein substrates of this phosphatase are not reported yet PPP3CC P48454 DNM1L , CRYAA , HSPB1 , JUN , MAPT , NEFH , PRKAR2A , ELK1 , FLNA , CANX , CSNK1E , GSK3B , VASP , DNM2 , RCAN1 , DNM1 , GAD2 , NFATC2 , PPP1R1A , SLC10A1 , KSR2 , SSH1 , BAD , GAD1 , PPP1R1B , TFEB , NFKBIA , LASP1 , Non-protein substrates of this phosphatase are not reported yet PPP1CA P62136 AURKA , AXIN1 , AHCYL1 , TBC1D4 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , PRKCB , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , EIF2AK2 , LMNB1 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , BRCA1 , CASP2 , TNNT2 , CSNK1E , CDK9 , CASP9 , PPP1CA , GAD2 , PTK2 , PRKCD , STK4 , STK3 , IKZF1 , CAMK2G , POLD3 , PRKD1 , PARD3 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , SF3B1 , POLR2A , RYR2 , SRSF1 , SLC6A3 , SENP3 , Non-protein substrates of this phosphatase are not reported yet PPP2CB P62714 SLC9A3R1 , CHEK1 , IKBKB , CHUK , AXIN1 , MAP3K7 , CHEK2 , MYC , CRYAA , MBP , RAF1 , TP53 , HSPB1 , ITGB1 , PRKCB , KRT8 , RB1 , CDK1 , RHO , VIM , BCL2 , MAPT , NEFH , SRC , EEF2 , H2AFX , CREB1 , PRKCA , PRKACA , RPS6KB1 , CDK2 , CAD , MAPK1 , RBL1 , AKT1 , ELF1 , SNCA , IL6ST , PRKCI , CASP3 , MAPK8 , MAP2K4 , CDKN1B , PXN , MAPKAPK2 , CSNK1E , VASP , CDK9 , RPS6KA3 , PLK1 , BCAR1 , HIST1H3A , SMAD3 , MDM2 , MAP2K1 , GAD2 , PRKCD , BAX , GOLGA2 , RBL2 , TRAF2 , STK4 , PRKAA1 , PAK1 , STK3 , ATM , PPP1R1A , CAMK2B , CAMK2G , BMPR2 , PRKG1 , CAMK1 , CDK5R1 , PRKD1 , PPP2R5A , RPS6KA1 , SMAD1 , MAPK14 , CAMK4 , PNCK , PACS1 , HDAC7 , BAD , GAD1 , SMO , CARD11 , RACGAP1 , SPHK1 , PPP1R1B , CAMK2A , AKT3 , EIF4E , RPA2 , APC , NFKBIA , RELA , RYR2 , Non-protein substrates of this phosphatase are not reported yet PPP2CA P67775 SLC9A3R1 , CHEK1 , IKBKB , CHUK , AXIN1 , MAP3K7 , CHEK2 , MYC , CRYAA , MBP , RAF1 , TP53 , HSPB1 , ITGB1 , PRKCB , KRT8 , RB1 , CDK1 , RHO , VIM , BCL2 , MAPT , NEFH , SRC , EEF2 , H2AFX , CREB1 , PRKCA , PRKACA , RPS6KB1 , CDK2 , CAD , MAPK1 , RBL1 , AKT1 , ELF1 , SNCA , IL6ST , PRKCI , CASP3 , MAPK8 , MAP2K4 , CDKN1B , PXN , MAPKAPK2 , CSNK1E , VASP , CDK9 , RPS6KA3 , PLK1 , BCAR1 , HIST1H3A , SMAD3 , MDM2 , MAP2K1 , RELA , GAD2 , PRKCD , BAX , GOLGA2 , RBL2 , TRAF2 , STK4 , PRKAA1 , PAK1 , STK3 , ATM , PPP1R1A , CAMK2B , CAMK2G , BMPR2 , PRKG1 , CAMK1 , CDK5R1 , PRKD1 , PPP2R5A , RPS6KA1 , SMAD1 , MAPK14 , CAMK4 , PNCK , PACS1 , HDAC7 , BAD , GAD1 , SMO , CARD11 , RACGAP1 , SPHK1 , PPP1R1B , CAMK2A , AKT3 , EIF4E , RPA2 , APC , NFKBIA , MAPK3 , RYR2 , SLC6A3 , PTEN , Non-protein substrates of this phosphatase are not reported yet PPP3CA Q08209 DNM1L , CRYAA , HSPB1 , JUN , MAPT , NEFH , PRKAR2A , ELK1 , FLNA , CANX , CSNK1E , GSK3B , VASP , DNM2 , RCAN1 , DNM1 , GAD2 , NFATC2 , PPP1R1A , SLC10A1 , KSR2 , SSH1 , BAD , GAD1 , PPP1R1B , TFEB , NFKBIA , LASP1 , TRPM3 , ORAI1 , Non-protein substrates of this phosphatase are not reported yet
Name UniProt AC Dephosphorylated by: PRKAR2A P13861 PPP3CA , PPP3CB , PPP3CC , PRKACA P17612 PPP2CA , PPP2CB , PPP1CA P62136 PPP1CA , PPP1R1B Q9UD71 PPP2CA , PPP2CB , PPP3CA , PPP3CB , PPP3CC ,
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