Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - Alcoholism - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| HDAC3 | O15379 | PPP4C, |
| RAF1 | P04049 | CDC25A, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPP5C, PTPN1, |
| HIST1H2AG | P0C0S8 | ALPL, ALPI, PPM1G, |
| H2AFX | P16104 | EYA1, EYA3, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPM1G, PPM1D, PPP4C, PPP6C, |
| CREB1 | P16220 | PPP2CA, PPP2CB, PTEN, |
| PRKACA | P17612 | PPP2CA, PPP2CB, |
| MAPK3 | P27361 | CDC25A, DUPD1, PTPN7, DUSP5, DUSP1, DUSP4, DUSP9, DUSP23, PTPRE, PTPRJ, DUSP3, PPP2CA, PTPRR, DUSP14, |
| MAPK1 | P28482 | CDC25A, DUSP22, DUPD1, PTPN7, DUSP5, DUSP1, DUSP4, DUSP6, DUSP9, DUSP7, DUSP2, PPP2CA, PPP2CB, PTPRE, PTPRJ, DUSP3, PTPRR, |
| SHC1 | P29353 | PTEN, PTPN2, |
| PPP1CA | P62136 | PPP1CA, |
| HIST1H4A | P62805 | PHPT1, |
| GNB1 | P62873 | PHPT1, |
| HIST1H3A | P68431 | PPP1CC, PPP2CA, PPP2CB, |
| MAP2K1 | Q02750 | PPP2CA, PPP2CB, |
| CAMK4 | Q16566 | PPM1F, PPM1E, PPP2CA, PPP2CB, |
| NTRK2 | Q16620 | PTPRS, |
| HDAC7 | Q8WUI4 | PPP2CA, PPP2CB, |
| HIST1H2BM | Q99879 | PPM1G, |
| PPP1R1B | Q9UD71 | PPP2CA, PPP2CB, PPP3CA, PPP3CB, PPP3CC, |
| SLC6A3 | Q01959 | PPP2CA, PPP1CA, |
| Non-protein substrates in this pathway |
Non-protein substrates involved in this pathway are unknown (yet!)