Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - Glucagon signaling pathway - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| FBP1 | P09467 | Protein substrates of this phosphatase are not reported yet | keto-D-fructose 1,6-bisphosphate, D-fructofuranose 1,6-bisphosphate, |
| PGAM2 | P15259 | Protein substrates of this phosphatase are not reported yet | 2,3-bisphospho-D-glyceric acid, |
| PFKFB1 | P16118 | Protein substrates of this phosphatase are not reported yet | beta-D-fructofuranose 2,6-bisphosphate, |
| PPP3CB | P16298 | DNM1L, CRYAA, HSPB1, JUN, MAPT, NEFH, PRKAR2A, ELK1, FLNA, CANX, CSNK1E, GSK3B, VASP, DNM2, RCAN1, DNM1, GAD2, NFATC2, PPP1R1A, SLC10A1, KSR2, SSH1, BAD, GAD1, PPP1R1B, TFEB, NFKBIA, LASP1, | Non-protein substrates of this phosphatase are not reported yet |
| PGAM1 | P18669 | Protein substrates of this phosphatase are not reported yet | 2,3-bisphospho-D-glyceric acid, |
| G6PC | P35575 | Protein substrates of this phosphatase are not reported yet | alpha-D-glucose 6-phosphate, beta-D-glucose 6-phosphate, |
| PPP3CC | P48454 | DNM1L, CRYAA, HSPB1, JUN, MAPT, NEFH, PRKAR2A, ELK1, FLNA, CANX, CSNK1E, GSK3B, VASP, DNM2, RCAN1, DNM1, GAD2, NFATC2, PPP1R1A, SLC10A1, KSR2, SSH1, BAD, GAD1, PPP1R1B, TFEB, NFKBIA, LASP1, | Non-protein substrates of this phosphatase are not reported yet |
| PPP4C | P60510 | HDAC3, RPA2, H2AFX, RELA, CCAR2, MAP4K1, NDEL1, | Non-protein substrates of this phosphatase are not reported yet |
| PPP3CA | Q08209 | DNM1L, CRYAA, HSPB1, JUN, MAPT, NEFH, PRKAR2A, ELK1, FLNA, CANX, CSNK1E, GSK3B, VASP, DNM2, RCAN1, DNM1, GAD2, NFATC2, PPP1R1A, SLC10A1, KSR2, SSH1, BAD, GAD1, PPP1R1B, TFEB, NFKBIA, LASP1, TRPM3, ORAI1, | Non-protein substrates of this phosphatase are not reported yet |
| PGAM4 | Q8N0Y7 | Protein substrates of this phosphatase are not reported yet | 2,3-bisphospho-D-glyceric acid, |
| G6PC3 | Q9BUM1 | Protein substrates of this phosphatase are not reported yet | alpha-D-glucose 6-phosphate, beta-D-glucose 6-phosphate, |
| G6PC2 | Q9NQR9 | Protein substrates of this phosphatase are not reported yet | alpha-D-glucose 6-phosphate, beta-D-glucose 6-phosphate, |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| PDHA1 | P08559 | PDP1, PDP2, |
| GYS1 | P13807 | ALPP, |
| CREB1 | P16220 | PPP2CA, PPP2CB, PTEN, |
| PRKACA | P17612 | PPP2CA, PPP2CB, |
| PDHA2 | P29803 | PDP1, PDP2, |
| AKT1 | P31749 | ACP1, PHLPP1, PHLPP2, PPP2CA, PPP2CB, PPP1CA, PPP1CB, PPP1CC, CTDSP1, |
| AKT2 | P31751 | PHLPP1, PHLPP2, |
| GCK | P35557 | DUSP12, |
| PRKAA1 | Q13131 | PPP2CA, PPP2CB, |
| CAMK2B | Q13554 | PPP2CA, PPP2CB, |
| CAMK2G | Q13555 | PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, CTDSPL, |
| CAMK2A | Q9UQM7 | PPM1F, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, |
| AKT3 | Q9Y243 | PHLPP1, PHLPP2, PPP2CA, PPP2CB, |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:15946 | C00085 | keto-D-fructose 6-phosphate |  | MDP1, |
| CHEBI:61553 | C00085 | D-fructofuranose 6-phosphate | | MDP1, |
| CHEBI:29042 | C00103 | alpha-D-glucose 1-phosphate |  | IMPA1, IMPA2, |
| CHEBI:28087 | C00182 | glycogen |  | EPM2A, |
| CHEBI:16905 | C00354 | keto-D-fructose 1,6-bisphosphate |  | FBP1, FBP2, NANP, TIGAR, |
| CHEBI:37736 | C00354 | D-fructofuranose 1,6-bisphosphate | | FBP1, FBP2, NANP, TIGAR, |
| CHEBI:28602 | C00665 | beta-D-fructofuranose 2,6-bisphosphate |  | PFKFB1, PFKFB2, PFKFB3, PFKFB4, TIGAR, |
| CHEBI:17665 | C00668 | alpha-D-glucose 6-phosphate |  | G6PC, G6PC2, G6PC3, IMPA1, |
| CHEBI:17719 | C01172 | beta-D-glucose 6-phosphate |  | G6PC, G6PC2, G6PC3, IMPA1, |
| CHEBI:16595 | C01245 | 1D-myo-inositol 1,4,5-trisphosphate |  | INPP5B, INPP5A, INPP5E, INPP5J, INPP5K, OCRL, SYNJ1, SYNJ2, |