DEPOD - human DEPhOsphorylation Database

Basic Information
Phosphatases
Pathway

Name	alpha-D-glucose 1-phosphate	Download: mol \| sdf
Synonyms	01-o-phosphono-alpha-d-glucopyranose; Alpha-d-glucose 1-phosphate; Alpha-d-glucose-1-phosphate; Cori ester; D-glucose 1-phosphate; D-glucose alpha-1-phosphate; Alpha-d-glucopyranose 1-phosphate;
Definition	A D-glucopyranose 1-phosphate in which the anomeric centre has alpha-configuration.
Molecular Weight (Exact mass)	260.1358 (260.0297)
Molecular Formula	C6H13O9P
SMILES	OC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H](O)[C@@H]1O
InChI	InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5-,6-/m1/s1
InChI Key	HXXFSFRBOHSIMQ-VFUOTHLCSA-N
Crosslinking annotations	KEGG:C00103 \| 3DMET:B04634 \| CAS:59-56-3 \| ChEBI:29042 \| KNApSAcK:C00007482 \| NIKKAJI:J40.065C \| PDB-CCD:G1P \| PubChem:3403 \|

Pathway ID	Pathway Name	Pathway Description (KEGG)
map00010	Glycolysis / Gluconeogenesis	Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
map00040	Pentose and glucuronate interconversions	NA
map00052	Galactose metabolism	NA
map00500	Starch and sucrose metabolism	NA
map00520	Amino sugar and nucleotide sugar metabolism	NA
map00521	Streptomycin biosynthesis	Streptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamine moieties, which are formed by independent biosynthetic pathways. All of the moieties are derived from D-glucose. The streptidine moiety is synthesized via myo-inositol, which is then oxidized at C-1 and transaminated to give scyllo-inosamine. After phosphorylation, the compound is transamidinated by arginine. The same procedure is repeated at the C-3 position. The streptose moiety is made from D-glucose via a dTDP-glucose pathway. The exact biosynthetic route for the N-methyl-L-glucosamine moiety is unknown, though the biosynthetic gene cluster have been proposed.
map00523	Polyketide sugar unit biosynthesis	NA
map00525	Acarbose and validamycin biosynthesis	NA
map00561	Glycerolipid metabolism	NA
map01060	Biosynthesis of plant secondary metabolites	NA
map01100	Metabolic pathways	NA
map01110	Biosynthesis of secondary metabolites	NA
map01120	Microbial metabolism in diverse environments	NA
map01130	Biosynthesis of antibiotics	NA
map04922	Glucagon signaling pathway	Glucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase blood glucose, glucagon promotes hepatic glucose output by increasing glycogenolysis and gluconeogenesis and by decreasing glycogenesis and glycolysis in a concerted fashion via multiple mechanisms. Glucagon also stimulates hepatic mitochondrial beta-oxidation to supply energy for glucose production. Glucagon performs its main effect via activation of adenylate cyclase. The adenylate-cyclase-derived cAMP activates protein kinase A (PKA), which then phosphorylates downstream targets, such as cAMP response element binding protein (CREB) and the bifunctional enzyme 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase (one of the isoforms being PFK/FBPase 1, encoded by PFKFB1).

CHEBI:29042