Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
299 KEGG pathways;
876 Reactome pathways;
last update: 11 Mar, 2019



Name alpha-D-glucose 1-phosphateC00103
Download: mol | sdf
Alpha-d-glucose 1-phosphate;
Cori ester;
D-glucose 1-phosphate;
D-glucose alpha-1-phosphate;
Alpha-d-glucopyranose 1-phosphate;
Definition A D-glucopyranose 1-phosphate in which the anomeric centre has alpha-configuration.
Molecular Weight
(Exact mass)
260.1358 (260.0297)
Molecular Formula C6H13O9P
SMILES OC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H](O)[C@@H]1O
InChI InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5-,6-/m1/s1
Crosslinking annotations KEGG:C00103 | 3DMET:B04634 | CAS:59-56-3 | ChEBI:29042 | KNApSAcK:C00007482 | NIKKAJI:J40.065C | PDB-CCD:G1P | PubChem:3403

Pathway ID Pathway Name Pathway Description (KEGG)
map00010Glycolysis / GluconeogenesisGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
map00040Pentose and glucuronate interconversionsNA
map00052Galactose metabolismNA
map00500Starch and sucrose metabolismNA
map00520Amino sugar and nucleotide sugar metabolismNA
map00521Streptomycin biosynthesisStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamine moieties, which are formed by independent biosynthetic pathways. All of the moieties are derived from D-glucose. The streptidine moiety is synthesized via myo-inositol, which is then oxidized at C-1 and transaminated to give scyllo-inosamine. After phosphorylation, the compound is transamidinated by arginine. The same procedure is repeated at the C-3 position. The streptose moiety is made from D-glucose via a dTDP-glucose pathway. The exact biosynthetic route for the N-methyl-L-glucosamine moiety is unknown, though the biosynthetic gene cluster have been proposed.
map00523Polyketide sugar unit biosynthesisNA
map00525Acarbose and validamycin biosynthesisNA
map00561Glycerolipid metabolismNA
map01060Biosynthesis of plant secondary metabolitesNA
map01100Metabolic pathwaysNA
map01110Biosynthesis of secondary metabolitesNA
map01120Microbial metabolism in diverse environmentsNA
map01130Biosynthesis of antibioticsNA
map04922Glucagon signaling pathwayGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase blood glucose, glucagon promotes hepatic glucose output by increasing glycogenolysis and gluconeogenesis and by decreasing glycogenesis and glycolysis in a concerted fashion via multiple mechanisms. Glucagon also stimulates hepatic mitochondrial beta-oxidation to supply energy for glucose production. Glucagon performs its main effect via activation of adenylate cyclase. The adenylate-cyclase-derived cAMP activates protein kinase A (PKA), which then phosphorylates downstream targets, such as cAMP response element binding protein (CREB) and the bifunctional enzyme 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase (one of the isoforms being PFK/FBPase 1, encoded by PFKFB1).