Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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CDC42BPB
Gene Name  | CDC42BPB (QuickGO) | (A quick tutorial to explore the interctive visulaization) Representative structure: 3TKU |
| Synonyms | CDC42BPB , KIAA1124 | |
| Protein Name | CDC42BPB | |
| Alternative Name(s) | Serine/threonine-protein kinase MRCK beta;2.7.11.1;CDC42-binding protein kinase beta;CDC42BP-beta;DMPK-like beta;Myotonic dystrophy kinase-related CDC42-binding kinase beta;MRCK beta;Myotonic dystrophy protein kinase-like beta; | |
| Protein Family | Belongs to the protein kinase superfamily AGC Ser/Thrprotein kinase family DMPK subfamily | |
| EntrezGene ID | 9578 (Comparitive Toxicogenomics) | |
| UniProt AC (Human) | Q9Y5S2 (protein sequence) | |
| Enzyme Class | 2.7.11.1 (BRENDA ) | |
| Molecular Weight | 194315 Dalton | |
| Protein Length | 1711 amino acids (AA) | |
| Genome Browsers | NCBI | ENSG00000198752 (Ensembl) | UCSC | |
| Crosslinking annotations | Query our ID-mapping table | |
| Orthologues | Quest For Orthologues (QFO) | GeneTree | eggNOG - ENOG410IT51 | eggNOG - COG0515 | |
| Phosphorylation Network | Visualize | |
| Domain organization, Expression, Diseases | (show / hide) |
| Protein Domain | InterPro | Pfam | SMART | 3D Structure | PDB | DrugPort | ModBase | SwissModel |
| Polypeptide organization (Pfam)  | |||
| Gene Expression | Gene Expression Atlas | Disease | OMIM | COSMIC | ClinVar |
| Protein-protein interactions | STRING | IntAct | MINT | BioGRID | ||
| Phosphosites | Phospho.ELM | PhosphoSitePlus |
| Localization, Function, Catalytic activity and Sequence | (show / hide) |
| Localization (UniProt annotation) | |||
| Cytoplasm Cell membrane Cell junction Cell projection, lamellipodium Note=Displays a dispersed punctatedistribution and concentrates along the cell periphery, especiallyat the leading edge and cell-cell junction This concentration isPH-domain dependent (By similarity) Detected at the leading edgeof migrating cells Localization at the leading edge of migratingcells requires interaction with catalytically active CDC42(PubMed:21240187) Localizes in the lamellipodium in aFAM89B/LRAP25-dependent manner (By similarity) | |||
| Function (UniProt annotation) | |||
| Serine/threonine-protein kinase which is an importantdownstream effector of CDC42 and plays a role in the regulation ofcytoskeleton reorganization and cell migration Regulates actincytoskeletal reorganization via phosphorylation of PPP1R12C andMYL9/MLC2 (PubMed:21457715, PubMed:21949762) In concert withMYO18A and LURAP1, is involved in modulating lamellar actomyosinretrograde flow that is crucial to cell protrusion and migration(PubMed:18854160) Phosphorylates PPP1R12A (PubMed:21457715) Inconcert with FAM89B/LRAP25 mediates the targeting of LIMK1 to thelamellipodium resulting in its activation and subsequentphosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity) | |||
| Catalytic Activity (UniProt annotation) | |||
| ATP + a protein = ADP + a phosphoprotein | |||
| Protein Sequence | |||
| MSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIK VIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGD LLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTP DYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRL ICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIG FTFTTESCFSDRGSLKSIMQSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSN SNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQEKEELHKQLVEASERLKSQA KELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEA SKERKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVH DSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDE LQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELEALRSSSLGSRTLDPLWKVRRSQKLDMSARLELQ SALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNTAPL AHDLTFRTSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALALAGPKPKAHQFSIKSFSSPTQCS HCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPIPPEQSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAV VCDCKLFLYDLPEGKSTQPGVIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTENEN EKRKWVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAILTAAIVDADRIAVGLEEGLYVIEVTRDVIVRAADCKK VHQIELAPREKIVILLCGRNHHVHLYPWSSLDGAEGSFDIKLPETKGCQLMATATLKRNSGTCLFVAVKRLILCYEIQRT KPFHRKFNEIVAPGSVQCLAVLRDRLCVGYPSGFCLLSIQGDGQPLNLVNPNDPSLAFLSQQSFDALCAVELESEEYLLC FSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTMEWVQTIGLRRIRPLNSEGTLNLLNCEPP RLIYFKSKFSGAVLNVPDTSDNSKKQMLRTRSKRRFVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDG MQVLMDLPLSAVPPSQEERPGPAPTNLARQPPSRNKPYISWPSSGGSEPSVTVPLRSMSDPDQDFDKEPDSDSTKHSTPS NSSNPSGPPSPNSPHRSQLPLEGLEQPACDT | |||
| Motif information from Eukaryotic Linear Motif atlas (ELM) | (show / hide) |
| ELM Motif | Motif Instance
| Description | Motif Regex |
| NA | NA | NA | NA |
| Gene Ontology (P: Process; F: Function and C: Component terms) | (show / hide) | |
| GO:0000287 | F:magnesium ion binding |
| GO:0004672 | F:protein kinase activity |
| GO:0004674 | F:protein serine/threonine kinase activity |
| GO:0005524 | F:ATP binding |
| GO:0005737 | C:cytoplasm |
| GO:0005856 | C:cytoskeleton |
| GO:0005886 | C:plasma membrane |
| GO:0005911 | C:cell-cell junction |
| GO:0006468 | P:protein phosphorylation |
| GO:0007010 | P:cytoskeleton organization |
| GO:0007163 | P:establishment or maintenance of cell polarity |
| GO:0007165 | P:signal transduction |
| GO:0016477 | P:cell migration |
| GO:0017048 | F:Rho GTPase binding |
| GO:0030027 | C:lamellipodium |
| GO:0031032 | P:actomyosin structure organization |
| GO:0031252 | C:cell leading edge |
| GO:0031532 | P:actin cytoskeleton reorganization |
| GO:0035556 | P:intracellular signal transduction |
| GO:0042641 | C:actomyosin |
| GO:0044877 | F:protein-containing complex binding |
| GO:0070062 | C:extracellular exosome |
