Top MTMR9
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-1660499 Synthesis of PIPs at the plasma membrane. At the plasma membrane, subsequent phosphorylation of phosphatidylinositol 4-phosphate (PI4P) produces phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) while the actions of various other kinases and phosphatases produces phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 5-phosphate (PI5P), phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (Zhang et al. 1997, Gurung et al. 2003, Guo et al. 1999, Vanhaesebroeck et al. 1997, Tolias et al. 1998, Schaletzky et al. 2003, Kim et al. 2002, Clarke et al. 2010). Many of the phosphatidylinositol phosphatases that act at the plasma membrane belong to the myotubularin family. Enzymatically inactive myotubularin family members can heterodimerize with catalytically active mytotubularins to regulate their stability, activity and/or substrate specificity (Berger et al. 2006, Zou et al. 2012) R-HSA-1660517 Synthesis of PIPs at the late endosome membrane. At the late endosome membrane, the primary event is the dephosphorylation of the phosphoinositide phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 5-phosphate (PI5P) (Sbrissa et al. 2007, Sbrissa et al. 2008, Cao et al. 2007, Cao et al. 2008, Arcaro et al. 2000, Kim et al. 2002) R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol. Inositol phosphates IP2, IP and the six-carbon cyclic alcohol inositol (Ins) are produced by various phosphatases and the inositol-3-phosphate synthase 1 (ISYNA1) (Ju et al. 2004, Ohnishi et al. 2007, Irvine & Schell 2001, Bunney & Katan 2010)
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source APOD Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ATP5IF1 Affinity Capture-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID CDA Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CLU Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CTSE Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CUL3 Affinity Capture-MS physical 21145461 , (Europe PMC )NA BioGRID DSP Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID ELAVL1 Affinity Capture-RNA physical 19322201 , (Europe PMC )NA BioGRID EMILIN1 Two-hybrid, two hybrid, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach, validated two hybrid physical, physical association 16189514 , 19447967 , 21516116 , 25416956 , Europe PMC )0.49, 0.80 BioGRID, IntAct, MINT ERBB3 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB4 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID EWSR1 Two-hybrid, two hybrid pooling approach physical, physical association 16189514 , (Europe PMC )0.37 BioGRID, IntAct KCTD17 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID KDM1A Two-hybrid, two hybrid physical, physical association 23455924 , (Europe PMC )0.37 BioGRID, IntAct, MINT LNX1 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct MOS Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct MTMR2 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID MTMR6 Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Proximity Label-MS, Reconstituted Complex, Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 12890864 , 21516116 , 25416956 , 26344197 , 27880917 , 28514442 , Europe PMC )0.76 BioGRID, IntAct, MINT MTMR7 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 12890864 , 25416956 , 27880917 , 28514442 , Europe PMC )0.70 BioGRID, IntAct MTMR8 Affinity Capture-MS, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, two hybrid pooling approach physical, physical association 16189514 , 22647598 , 27432908 , 27880917 , 28514442 , (Europe PMC )0.37, 0.52 BioGRID, IntAct MTMR9 Affinity Capture-MS, Reconstituted Complex, Two-hybrid, two hybrid array, two hybrid pooling approach physical, physical association 12890864 , 16189514 , 25416956 , 27432908 , (Europe PMC )0.55 BioGRID, IntAct NMI Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , Europe PMC )0.70 BioGRID, IntAct PTK7 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ROR2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID SPG21 Two-hybrid, two hybrid pooling approach physical, physical association 16189514 , (Europe PMC )0.37 BioGRID, IntAct VAC14 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct WDR45B Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID XPO1 Affinity Capture-MS physical 26673895 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source EWSR1 Two-hybrid, two hybrid pooling approach physical, physical association 16189514 , (Europe PMC )0.37 BioGRID, IntAct KDM1A Two-hybrid, two hybrid physical, physical association 23455924 , (Europe PMC )0.37 BioGRID, IntAct, MINT LNX1 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct MOS Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct MTMR6 Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Proximity Label-MS, Reconstituted Complex, Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 12890864 , 21516116 , 25416956 , 26344197 , 27880917 , 28514442 , Europe PMC )0.76 BioGRID, IntAct, MINT MTMR7 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 12890864 , 25416956 , 27880917 , 28514442 , Europe PMC )0.70 BioGRID, IntAct MTMR8 Affinity Capture-MS, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, two hybrid pooling approach physical, physical association 16189514 , 22647598 , 27432908 , 27880917 , 28514442 , (Europe PMC )0.37, 0.52 BioGRID, IntAct MTMR9 Affinity Capture-MS, Reconstituted Complex, Two-hybrid, two hybrid array, two hybrid pooling approach physical, physical association 12890864 , 16189514 , 25416956 , 27432908 , (Europe PMC )0.55 BioGRID, IntAct NMI Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , Europe PMC )0.70 BioGRID, IntAct SPG21 Two-hybrid, two hybrid pooling approach physical, physical association 16189514 , (Europe PMC )0.37 BioGRID, IntAct VAC14 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source KDM1A Two-hybrid, two hybrid physical, physical association 23455924 , (Europe PMC )0.37 BioGRID, IntAct, MINT MTMR6 Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Proximity Label-MS, Reconstituted Complex, Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 12890864 , 21516116 , 25416956 , 26344197 , 27880917 , 28514442 , Europe PMC )0.76 BioGRID, IntAct, MINT
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source APOD Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ATP5IF1 Affinity Capture-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID CDA Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CLU Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CTSE Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CUL3 Affinity Capture-MS physical 21145461 , (Europe PMC )NA BioGRID DSP Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID ELAVL1 Affinity Capture-RNA physical 19322201 , (Europe PMC )NA BioGRID EMILIN1 Two-hybrid, two hybrid, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach, validated two hybrid physical, physical association 16189514 , 19447967 , 21516116 , 25416956 , Europe PMC )0.49, 0.80 BioGRID, IntAct, MINT ERBB3 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB4 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID EWSR1 Two-hybrid, two hybrid pooling approach physical, physical association 16189514 , (Europe PMC )0.37 BioGRID, IntAct KCTD17 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID KDM1A Two-hybrid, two hybrid physical, physical association 23455924 , (Europe PMC )0.37 BioGRID, IntAct, MINT LNX1 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct MOS Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct MTMR2 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID MTMR6 Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Proximity Label-MS, Reconstituted Complex, Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 12890864 , 21516116 , 25416956 , 26344197 , 27880917 , 28514442 , Europe PMC )0.76 BioGRID, IntAct, MINT MTMR7 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 12890864 , 25416956 , 27880917 , 28514442 , Europe PMC )0.70 BioGRID, IntAct MTMR8 Affinity Capture-MS, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, two hybrid pooling approach physical, physical association 16189514 , 22647598 , 27432908 , 27880917 , 28514442 , (Europe PMC )0.37, 0.52 BioGRID, IntAct MTMR9 Affinity Capture-MS, Reconstituted Complex, Two-hybrid, two hybrid array, two hybrid pooling approach physical, physical association 12890864 , 16189514 , 25416956 , 27432908 , (Europe PMC )0.55 BioGRID, IntAct NMI Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , Europe PMC )0.70 BioGRID, IntAct PTK7 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ROR2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID SPG21 Two-hybrid, two hybrid pooling approach physical, physical association 16189514 , (Europe PMC )0.37 BioGRID, IntAct VAC14 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct WDR45B Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID XPO1 Affinity Capture-MS physical 26673895 , (Europe PMC )NA BioGRID
Phosphorylating Kinases Phosphoresidues Detection Method PubMed IDs Source
Visualize a network of protein kinases and phosphatases phosphorylating and dephosphorylating this protein respectively
Unknown S548_TEDGMQEsP , T178_EALRKVAtFRHGGRF , HTP, in vivo 18669648 , 19413330 , 19651622 , 19664995 , 20068231 ,(Europe PMC )HPRD, PhosphoELM ,
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