DEPOD - human DEPhOsphorylation Database

Basic Information
Phosphatases
Pathway

Name	2-trans,6-trans-farnesyl diphosphate	Download: mol \| sdf
Synonyms	0(2e,6e)-farnesyl diphosphate; 2-trans,6-trans-farnesyl diphosphate; 3,7,11-trimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate; Farnesyl diphosphate; Farnesyl pyrophosphate; Fdp; Trans,trans-farnesyl diphosphate;
Definition	The trans,trans-stereoisomer of farnesyl diphosphate.
Molecular Weight (Exact mass)	382.3261 (382.131)
Molecular Formula	C15H28O7P2
SMILES	CC(C)=CCC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O
InChI	InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+
InChI Key	VWFJDQUYCIWHTN-YFVJMOTDSA-N
Crosslinking annotations	KEGG:C00448 \| 3DMET:B01245 \| CAS:372-97-4 \| ChEBI:17407 \| ChEMBL:CHEMBL69330 \| KNApSAcK:C00000907 \| KNApSAcK:C00007268 \| LIPIDMAPS:LMPR0103010002 \| LipidBank:IIP0005 \| NIKKAJI:J348.314B \| PDB-CCD:FPP \| PubChem:3736 \|

Pathway ID	Pathway Name	Pathway Description (KEGG)
map00100	Steroid biosynthesis	NA
map00900	Terpenoid backbone biosynthesis	Terpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mevalonate pathway or the MEP/DOXP pathway [MD:M00096], for the terpenoid building blocks: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). The action of prenyltransferases then generates higher-order building blocks: geranyl diphosphate (GPP), farsenyl diphosphate (FPP), and geranylgeranyl diphosphate (GGPP), which are the precursors of monoterpenoids (C10), sesquiterpenoids (C15), and diterpenoids (C20), respectively. Condensation of these building blocks gives rise to the precursors of sterols (C30) and carotenoids (C40). The MEP/DOXP pathway is absent in higher animals and fungi, but in green plants the MEP/DOXP and mevalonate pathways co-exist in separate cellular compartments. The MEP/DOXP pathway, operating in the plastids, is responsible for the formation of essential oil monoterpenes and linalyl acetate, some sesquiterpenes, diterpenes, and carotenoids and phytol. The mevalonate pathway, operating in the cytosol, gives rise to triterpenes, sterols, and most sesquiterpenes.
map00906	Carotenoid biosynthesis	NA
map00909	Sesquiterpenoid and triterpenoid biosynthesis	Sesquiterpenoids (C15 terpenoids) are a group of terpenoids consisting of three isoprene units. They are derive from farnesyl diphosphate (FPP) and can be cyclized to produce various skeletal structures. Sesquiterpenoid biosynthesis begins with the loss of diphosphate from FPP under the action of sesquiterpene synthesis enzymes, generating an allylic cation that is highly susceptible to intramolecular attacks. Cyclization of the farnesyl cation may take place onto either of the remaining double bonds with the result that 6-, 10-, or 11-membered rings may be formed. Many sesquiterpenoids have been isolated from plants, fungi, marine organisms, and Streptomyces species. This map shows a few examples of acyclic and cyclic sesquiterpenoids.
map00981	Insect hormone biosynthesis	NA
map00999	Biosynthesis of secondary metabolites - unclassified	NA
map01060	Biosynthesis of plant secondary metabolites	NA
map01062	Biosynthesis of terpenoids and steroids	NA
map01066	Biosynthesis of alkaloids derived from terpenoid and polyketide	NA
map01070	Biosynthesis of plant hormones	NA
map01100	Metabolic pathways	NA
map01110	Biosynthesis of secondary metabolites	NA
map01130	Biosynthesis of antibiotics	NA

CHEBI:17407