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KEGG Pathway - PI3K-Akt signaling pathway - Homo sapiens (human) Name UniProt AC Dephosphorylates following protein substrates: Dephosphorylates following non-protein substrates: PHLPP1 O60346 PRKCB , PRKCA , RPS6KB1 , AKT1 , AKT2 , STK4 , AKT3 , Non-protein substrates of this phosphatase are not reported yet G6PC P35575 Protein substrates of this phosphatase are not reported yet alpha-D-glucose 6-phosphate , beta-D-glucose 6-phosphate , PTEN P60484 PDGFRB , CREB1 , SHC1 , PTEN , PTK2 , PTK6 , 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate , 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate , 1D-myo-inositol 1,3,4,5-tetrakisphosphate , 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate , 1-phosphatidyl-1D-myo-inositol 3-phosphate , PPP2CB P62714 SLC9A3R1 , CHEK1 , IKBKB , CHUK , AXIN1 , MAP3K7 , CHEK2 , MYC , CRYAA , MBP , RAF1 , TP53 , HSPB1 , ITGB1 , PRKCB , KRT8 , RB1 , CDK1 , RHO , VIM , BCL2 , MAPT , NEFH , SRC , EEF2 , H2AFX , CREB1 , PRKCA , PRKACA , RPS6KB1 , CDK2 , CAD , MAPK1 , RBL1 , AKT1 , ELF1 , SNCA , IL6ST , PRKCI , CASP3 , MAPK8 , MAP2K4 , CDKN1B , PXN , MAPKAPK2 , CSNK1E , VASP , CDK9 , RPS6KA3 , PLK1 , BCAR1 , HIST1H3A , SMAD3 , MDM2 , MAP2K1 , GAD2 , PRKCD , BAX , GOLGA2 , RBL2 , TRAF2 , STK4 , PRKAA1 , PAK1 , STK3 , ATM , PPP1R1A , CAMK2B , CAMK2G , BMPR2 , PRKG1 , CAMK1 , CDK5R1 , PRKD1 , PPP2R5A , RPS6KA1 , SMAD1 , MAPK14 , CAMK4 , PNCK , PACS1 , HDAC7 , BAD , GAD1 , SMO , CARD11 , RACGAP1 , SPHK1 , PPP1R1B , CAMK2A , AKT3 , EIF4E , RPA2 , APC , NFKBIA , RELA , RYR2 , Non-protein substrates of this phosphatase are not reported yet PPP2CA P67775 SLC9A3R1 , CHEK1 , IKBKB , CHUK , AXIN1 , MAP3K7 , CHEK2 , MYC , CRYAA , MBP , RAF1 , TP53 , HSPB1 , ITGB1 , PRKCB , KRT8 , RB1 , CDK1 , RHO , VIM , BCL2 , MAPT , NEFH , SRC , EEF2 , H2AFX , CREB1 , PRKCA , PRKACA , RPS6KB1 , CDK2 , CAD , MAPK1 , RBL1 , AKT1 , ELF1 , SNCA , IL6ST , PRKCI , CASP3 , MAPK8 , MAP2K4 , CDKN1B , PXN , MAPKAPK2 , CSNK1E , VASP , CDK9 , RPS6KA3 , PLK1 , BCAR1 , HIST1H3A , SMAD3 , MDM2 , MAP2K1 , RELA , GAD2 , PRKCD , BAX , GOLGA2 , RBL2 , TRAF2 , STK4 , PRKAA1 , PAK1 , STK3 , ATM , PPP1R1A , CAMK2B , CAMK2G , BMPR2 , PRKG1 , CAMK1 , CDK5R1 , PRKD1 , PPP2R5A , RPS6KA1 , SMAD1 , MAPK14 , CAMK4 , PNCK , PACS1 , HDAC7 , BAD , GAD1 , SMO , CARD11 , RACGAP1 , SPHK1 , PPP1R1B , CAMK2A , AKT3 , EIF4E , RPA2 , APC , NFKBIA , MAPK3 , RYR2 , SLC6A3 , PTEN , Non-protein substrates of this phosphatase are not reported yet PHLPP2 Q6ZVD8 PRKCB , PRKCA , RPS6KB1 , AKT1 , AKT2 , STK4 , AKT3 , Non-protein substrates of this phosphatase are not reported yet G6PC3 Q9BUM1 Protein substrates of this phosphatase are not reported yet alpha-D-glucose 6-phosphate , beta-D-glucose 6-phosphate , G6PC2 Q9NQR9 Protein substrates of this phosphatase are not reported yet alpha-D-glucose 6-phosphate , beta-D-glucose 6-phosphate ,
Name UniProt AC Dephosphorylated by: IKBKB O14920 PPP2CA , PPP2CB , PPM1A , PPM1B , PPM1M , CHUK O15111 PPP2CA , PPP2CB , JAK2 O60674 PTPRC , PTPN1 , PTPN6 , PTPN11 , EGFR P00533 CDC25A , ACP1 , PTPN1 , PTPN9 , PTPRU , PTPRJ , PTPRK , PTPRS , PTPN6 , PTPN11 , PTPN2 , DUSP3 , UBASH3B , PTPRA , PTPRB , PTPN12 , PTPRH , MYC P01106 PPP2CA , PPP2CB , CTDSP1 , RAF1 P04049 CDC25A , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPP5C , PTPN1 , ERBB2 P04626 ACPP , PTPN9 , DUSP3 , PTPN6 , PTPN12 , PTPN11 , PTPN18 , PTPN11 , NTRK1 P04629 PTPRZ1 , PTPRS , PTPN6 , TP53 P04637 CDC14A , CDC14B , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPM1D , DUSP26 , ITGB1 P05556 PPP2CA , PPP2CB , PTP4A3 , INSR P06213 PTPRF , ACP1 , PTPN1 , PTPRE , PTPN2 , DUSP3 , IGF1R P08069 PTPN1 , MET P08581 PTPRF , PTPN1 , PTPRB , PTPRJ , PTPN2 , PDGFRB P09619 ACP1 , PTEN , PTPN1 , PTPRJ , PTPN11 , PTPN2 , DUSP3 , BCL2 P10415 PPP2CA , PPP2CB , KIT P10721 PTPN6 , GHR P10912 PTPN1 , PTPN3 , CDK4 P11802 CDC25A , GYS1 P13807 ALPP , CREB1 P16220 PPP2CA , PPP2CB , PTEN , PRKCA P17252 PHLPP1 , PHLPP2 , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , EPOR P19235 PTPN1 , FGFR2 P21802 DUSP3 , RPS6KB1 P23443 PPP2CA , PPP2CB , PHLPP1 , PHLPP2 , JAK1 P23458 PTPRC , PTPN2 , CDK2 P24941 CDC25A , CDKN3 , PPP2CA , PPP2CB , PPM1A , PPM1B , MAPK3 P27361 CDC25A , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP9 , DUSP23 , PTPRE , PTPRJ , DUSP3 , PPP2CA , PTPRR , DUSP14 , PIK3R1 P27986 PPM1A , PTPRJ , MAPK1 P28482 CDC25A , DUSP22 , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP6 , DUSP9 , DUSP7 , DUSP2 , PPP2CA , PPP2CB , PTPRE , PTPRJ , DUSP3 , PTPRR , NOS3 P29474 PPP1CA , PPP1CB , PPP1CC , AKT1 P31749 ACP1 , PHLPP1 , PHLPP2 , PPP2CA , PPP2CB , PPP1CA , PPP1CB , PPP1CC , CTDSP1 , AKT2 P31751 PHLPP1 , PHLPP2 , IRS1 P35568 PTPN1 , PTPN13 , PTPN11 , PPP1CA , PPP1CB , PPP1CC , KDR P35968 ACP1 , PTPRB , PTPRJ , PTPN6 , PTPN11 , PTPN2 , BRCA1 P38398 PPP1CA , SYK P43405 UBASH3B , CDKN1B P46527 CDC14A , PPM1H , PPP2CB , PPP2CA , GSK3B P49841 EPM2A , PPP3CA , PPP3CB , PPP3CC , PTPN1 , JAK3 P52333 PTPRC , PTPN2 , CASP9 P55211 PPP1CA , PTEN P60484 PTEN , PPP2CA , GNB1 P62873 PHPT1 , CDK6 Q00534 PPM1A , PPM1B , MDM2 Q00987 PPP2CA , PPP2CB , PPM1D , MAP2K1 Q02750 PPP2CA , PPP2CB , TEK Q02763 PTPRB , RELA Q04206 PPP2CA , PPP4C , PPP2CB , PTK2 Q05397 PTPN23 , ACP1 , PPP1CA , PPP1CB , PPP1CC , PTEN , PTPN1 , PTPN12 , UBASH3B , RBL2 Q08999 PPP2CA , PPP2CB , PRKAA1 Q13131 PPP2CA , PPP2CB , PPP2R5A Q15172 PPP2CA , PPP2CB , ERBB4 Q15303 ACP4 , PTPN6 , PTPN11 , CDC37 Q16543 PPP5C , NTRK2 Q16620 PTPRS , BAD Q92934 ALPL , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPP3CA , PPP3CB , PPP3CC , PPM1B , PPP5C , AKT3 Q9Y243 PHLPP1 , PHLPP2 , PPP2CA , PPP2CB , EIF4E P06730 PPP2CB , PPP2CA ,
ChEBI ID KEGG ID ChEBIasciiName Molecule Dephosphorylated by: CHEBI:16027 C00020 adenosine 5'-monophosphate ACPP , ALPL , NT5E , NT5C1A , CHEBI:18348 C04637 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate FIG4 , INPP5B , INPP5E , INPP5J , INPP5K , OCRL , PTP4A3 , PTPRQ , INPP5F , SYNJ1 , SYNJ2 , CHEBI:16618 C05981 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate TNS2 , FIG4 , INPP5B , INPP5E , INPP5K , OCRL , PTEN , PTPRQ , INPP5F , INPP5D , INPPL1 , SYNJ1 , SYNJ2 , TPTE2 ,
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