Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - MAPK signaling pathway - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| PPM1B | O75688 | IKBKB, MAP3K7, CDK2, MSN, CETN2, CDK9, CDK6, CETN1, BAD, ARHGDIA, | Non-protein substrates of this phosphatase are not reported yet |
| PPP3CB | P16298 | DNM1L, CRYAA, HSPB1, JUN, MAPT, NEFH, PRKAR2A, ELK1, FLNA, CANX, CSNK1E, GSK3B, VASP, DNM2, RCAN1, DNM1, GAD2, NFATC2, PPP1R1A, SLC10A1, KSR2, SSH1, BAD, GAD1, PPP1R1B, TFEB, NFKBIA, LASP1, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP1 | P28562 | MAPK3, MAPK1, MAPK8, MAPK9, MAPK14, | Non-protein substrates of this phosphatase are not reported yet |
| CDC25B | P30305 | CDK1, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN7 | P35236 | MAPK3, MAPK1, MAPK14, | Non-protein substrates of this phosphatase are not reported yet |
| PPM1A | P35813 | IKBKB, AXIN1, EEF2, CDK2, MSN, PIK3R1, MAP2K4, CDK9, MAP2K6, SMAD3, CDK6, PRKCD, CETN1, PAK1, PAK2, GRM3, SMAD2, SMAD1, MAPK14, CDC42BPA, CDC42BPB, | Non-protein substrates of this phosphatase are not reported yet |
| PPP3CC | P48454 | DNM1L, CRYAA, HSPB1, JUN, MAPT, NEFH, PRKAR2A, ELK1, FLNA, CANX, CSNK1E, GSK3B, VASP, DNM2, RCAN1, DNM1, GAD2, NFATC2, PPP1R1A, SLC10A1, KSR2, SSH1, BAD, GAD1, PPP1R1B, TFEB, NFKBIA, LASP1, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP3 | P51452 | EGFR, ERBB2, CSN2, INSR, PDGFRB, FGFR2, MAPK3, MAPK1, STAT5A, MAPK8, MAPK9, CSN1S1, MAPK14, | Non-protein substrates of this phosphatase are not reported yet |
| PPP5C | P53041 | RAF1, NR3C1, MAPT, CSNK1E, CDC37, BAD, MAP3K5, ICK, TTN, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN5 | P54829 | FYN, BAK1, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP2 | Q05923 | MAPK1, MAPK14, | Non-protein substrates of this phosphatase are not reported yet |
| PPP3CA | Q08209 | DNM1L, CRYAA, HSPB1, JUN, MAPT, NEFH, PRKAR2A, ELK1, FLNA, CANX, CSNK1E, GSK3B, VASP, DNM2, RCAN1, DNM1, GAD2, NFATC2, PPP1R1A, SLC10A1, KSR2, SSH1, BAD, GAD1, PPP1R1B, TFEB, NFKBIA, LASP1, TRPM3, ORAI1, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP4 | Q13115 | MAPK3, MAPK1, MAPK9, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP8 | Q13202 | MAPK8, MAPK14, | Non-protein substrates of this phosphatase are not reported yet |
| PTPRR | Q15256 | MAPK7, MAPK3, MAPK1, | Non-protein substrates of this phosphatase are not reported yet |
| TAB1 | Q15750 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| DUSP5 | Q16690 | MAPK3, MAPK1, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP6 | Q16828 | MAPK1, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP7 | Q16829 | MAPK1, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP9 | Q99956 | MAPK3, MAPK1, MAPK8, MAPK9, MAPK14, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP16 | Q9BY84 | MAPK9, MAPK10, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP10 | Q9Y6W6 | MAPK8, MAPK9, MAPK14, | Non-protein substrates of this phosphatase are not reported yet |
| Protein substrates in this pathway |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:16412 | C00338 | lipopolysaccharide | Image not available | ALPI, ALPP, |
| CHEBI:16595 | C01245 | 1D-myo-inositol 1,4,5-trisphosphate |  | INPP5B, INPP5A, INPP5E, INPP5J, INPP5K, OCRL, SYNJ1, SYNJ2, |