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KEGG Pathway - Pathways in cancer - Homo sapiens (human) Name UniProt AC Dephosphorylates following protein substrates: Dephosphorylates following non-protein substrates: PTEN P60484 PDGFRB , CREB1 , SHC1 , PTEN , PTK2 , PTK6 , 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate , 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate , 1D-myo-inositol 1,3,4,5-tetrakisphosphate , 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate , 1-phosphatidyl-1D-myo-inositol 3-phosphate ,
Name UniProt AC Dephosphorylated by: IKBKB O14920 PPP2CA , PPP2CB , PPM1A , PPM1B , PPM1M , CHUK O15111 PPP2CA , PPP2CB , AXIN1 O15169 PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPM1A , JAK2 O60674 PTPRC , PTPN1 , PTPN6 , PTPN11 , ABL1 P00519 PTPN18 , PTPN12 , EGFR P00533 CDC25A , ACP1 , PTPN1 , PTPN9 , PTPRU , PTPRJ , PTPRK , PTPRS , PTPN6 , PTPN11 , PTPN2 , DUSP3 , UBASH3B , PTPRA , PTPRB , PTPN12 , PTPRH , MYC P01106 PPP2CA , PPP2CB , CTDSP1 , ESR1 P03372 DUSP22 , PTPN1 , PTPN6 , RAF1 P04049 CDC25A , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPP5C , PTPN1 , ERBB2 P04626 ACPP , PTPN9 , DUSP3 , PTPN6 , PTPN12 , PTPN11 , PTPN18 , PTPN11 , NTRK1 P04629 PTPRZ1 , PTPRS , PTPN6 , TP53 P04637 CDC14A , CDC14B , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPM1D , DUSP26 , JUN P05412 PPP3CA , PPP3CB , PPP3CC , ITGB1 P05556 PPP2CA , PPP2CB , PTP4A3 , PRKCB P05771 PHLPP1 , PHLPP2 , PPP1CA , PPP2CA , PPP2CB , RB1 P06400 PPP1CA , PPP1CB , PPP1CC , CTDSPL , PPP2CA , PPP2CB , RET P07949 PTPRJ , IGF1R P08069 PTPN1 , MET P08581 PTPRF , PTPN1 , PTPRB , PTPRJ , PTPN2 , PDGFRB P09619 ACP1 , PTEN , PTPN1 , PTPRJ , PTPN11 , PTPN2 , DUSP3 , BCL2 P10415 PPP2CA , PPP2CB , KIT P10721 PTPN6 , CDK4 P11802 CDC25A , CDH1 P12830 PTPN23 , PTPRT , PRKCA P17252 PHLPP1 , PHLPP2 , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PRKACA P17612 PPP2CA , PPP2CB , PLCG1 P19174 PTPN1 , PTPRJ , EPOR P19235 PTPN1 , ELK1 P19419 PPP3CA , PPP3CB , PPP3CC , FGFR2 P21802 DUSP3 , CBL P22681 PTPRJ , UBASH3B , RPS6KB1 P23443 PPP2CA , PPP2CB , PHLPP1 , PHLPP2 , JAK1 P23458 PTPRC , PTPN2 , CDK2 P24941 CDC25A , CDKN3 , PPP2CA , PPP2CB , PPM1A , PPM1B , NFKBIA P25963 PTPN1 , PTPN13 , PPP3CB , PPP3CC , PPP2CB , PPP2CA , PPP3CA , MAPK3 P27361 CDC25A , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP9 , DUSP23 , PTPRE , PTPRJ , DUSP3 , PPP2CA , PTPRR , DUSP14 , PIK3R1 P27986 PPM1A , PTPRJ , MAPK1 P28482 CDC25A , DUSP22 , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP6 , DUSP9 , DUSP7 , DUSP2 , PPP2CA , PPP2CB , PTPRE , PTPRJ , DUSP3 , PTPRR , AKT1 P31749 ACP1 , PHLPP1 , PHLPP2 , PPP2CA , PPP2CB , PPP1CA , PPP1CB , PPP1CC , CTDSP1 , AKT2 P31751 PHLPP1 , PHLPP2 , CTNNB1 P35222 PTPN23 , PTPRF , ACP1 , PTPN14 , PTPN1 , PTPRU , PTPRK , DUSP23 , TGFBR1 P36897 PPP1CC , PPP1CA , PPP1CB , IL6ST P40189 PPP2CA , PPP2CB , STAT3 P40763 DUSP22 , PTPN1 , PTPRD , PTPRT , PTPN2 , STAT1 P42224 PTPN11 , PTPN2 , STAT6 P42226 PTPN1 , PTPN2 , STAT5A P42229 ACP1 , PTPN1 , PTPN11 , PTPN2 , DUSP3 , CASP3 P42574 PPP2CA , PPP2CB , MAPK8 P45983 DUSP22 , DUSP8 , DUSP18 , DUSP1 , DUSP9 , DUSP10 , PPP2CA , PPP2CB , DUSP3 , MAPK9 P45984 DUSP19 , DUSP1 , DUSP4 , DUSP9 , DUSP10 , DUSP16 , DUSP3 , DUSP14 , CRK P46108 PTPN1 , CDKN1B P46527 CDC14A , PPM1H , PPP2CB , PPP2CA , GSK3B P49841 EPM2A , PPP3CA , PPP3CB , PPP3CC , PTPN1 , STAT5B P51692 PTPN1 , PTPN11 , PTPN2 , JAK3 P52333 PTPRC , PTPN2 , MAPK10 P53779 DUSP16 , CASP9 P55211 PPP1CA , PTEN P60484 PTEN , PPP2CA , GNB1 P62873 PHPT1 , SMAD3 P84022 MTMR4 , PPP2CA , PPP2CB , PPM1A , CTDSP1 , CTDSP2 , CTDSPL , CDK6 Q00534 PPM1A , PPM1B , MDM2 Q00987 PPP2CA , PPP2CB , PPM1D , MAP2K1 Q02750 PPP2CA , PPP2CB , RELA Q04206 PPP2CA , PPP4C , PPP2CB , PTK2 Q05397 PTPN23 , ACP1 , PPP1CA , PPP1CB , PPP1CC , PTEN , PTPN1 , PTPN12 , UBASH3B , BAX Q07812 PPP2CA , PPP2CB , TRAF2 Q12933 PPP2CA , PPP2CB , STK4 Q13043 PHLPP1 , PHLPP2 , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , SKP2 Q13309 CDC14B , CAMK2B Q13554 PPP2CA , PPP2CB , CAMK2G Q13555 PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , CTDSPL , CASP8 Q14790 PTPN6 , SMAD2 Q15796 PPM1A , CTDSP1 , CTDSP2 , CTDSPL , BAK1 Q16611 PTPN5 , BAD Q92934 ALPL , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPP3CA , PPP3CB , PPP3CC , PPM1B , PPP5C , SMO Q99835 PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , ALK Q9UM73 PTPN1 , PTPRZ1 , CAMK2A Q9UQM7 PPM1F , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , AKT3 Q9Y243 PHLPP1 , PHLPP2 , PPP2CA , PPP2CB , APC P25054 PPP2CB , PPP2CA ,
ChEBI ID KEGG ID ChEBIasciiName Molecule Dephosphorylated by: CHEBI:16337 C00416 phosphatidic acid ACPP , PLPP5 , PLPP4 , LPIN1 , LPIN2 , LPIN3 , PLPPR2 , PLPPR3 , PLPPR4 , PLPP1 , PLPP3 , PLPP2 , PLPP6 , CHEBI:16975 C00681 1-acyl-sn-glycerol 3-phosphate ACP6 , ACPP , PLPP5 , PLPP4 , PLPPR4 , PLPP1 , PLPP3 , PLPP2 , EPHX2 , CHEBI:16595 C01245 1D-myo-inositol 1,4,5-trisphosphate INPP5B , INPP5A , INPP5E , INPP5J , INPP5K , OCRL , SYNJ1 , SYNJ2 , CHEBI:16618 C05981 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate TNS2 , FIG4 , INPP5B , INPP5E , INPP5K , OCRL , PTEN , PTPRQ , INPP5F , INPP5D , INPPL1 , SYNJ1 , SYNJ2 , TPTE2 ,
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