Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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KEGG Pathway - Phospholipase D signaling pathway - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| PLPP1 | O14494 | Protein substrates of this phosphatase are not reported yet | N-acylsphingosine 1-phosphate, phosphatidic acid, 1-acyl-sn-glycerol 3-phosphate, sphingosine 1-phosphate, |
| PLPP3 | O14495 | Protein substrates of this phosphatase are not reported yet | N-acylsphingosine 1-phosphate, phosphatidic acid, 1-acyl-sn-glycerol 3-phosphate, sphingosine 1-phosphate, |
| PLPP2 | O43688 | Protein substrates of this phosphatase are not reported yet | N-acylsphingosine 1-phosphate, phosphatidic acid, 1-acyl-sn-glycerol 3-phosphate, sphingosine 1-phosphate, |
| PTPN11 | Q06124 | SPRY2, SPRY1, JAK2, MPZL1, EGFR, PDGFRB, SRC, SELE, IRS1, KDR, STAT1, STAT5A, PXN, STAT5B, SIRPA, ARHGAP5, GAB1, PTK2B, PAG1, GAB2, MAP3K4, ERBB2, LCK, CD28, ERBB2, PDCD1, ERBB4, | Non-protein substrates of this phosphatase are not reported yet |
| Protein substrates in this pathway |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:16337 | C00416 | phosphatidic acid |  | ACPP, PLPP5, PLPP4, LPIN1, LPIN2, LPIN3, PLPPR2, PLPPR3, PLPPR4, PLPP1, PLPP3, PLPP2, PLPP6, |
| CHEBI:16975 | C00681 | 1-acyl-sn-glycerol 3-phosphate |  | ACP6, ACPP, PLPP5, PLPP4, PLPPR4, PLPP1, PLPP3, PLPP2, EPHX2, |
| CHEBI:16595 | C01245 | 1D-myo-inositol 1,4,5-trisphosphate |  | INPP5B, INPP5A, INPP5E, INPP5J, INPP5K, OCRL, SYNJ1, SYNJ2, |
| CHEBI:18348 | C04637 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate |  | FIG4, INPP5B, INPP5E, INPP5J, INPP5K, OCRL, PTP4A3, PTPRQ, INPP5F, SYNJ1, SYNJ2, |
| CHEBI:16618 | C05981 | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate |  | TNS2, FIG4, INPP5B, INPP5E, INPP5K, OCRL, PTEN, PTPRQ, INPP5F, INPP5D, INPPL1, SYNJ1, SYNJ2, TPTE2, |
| CHEBI:37550 | C06124 | sphingosine 1-phosphate |  | PLPP1, PLPP3, PLPP2, SGPP1, SGPP2, |