Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| PTEN | P60484 | PDGFRB, CREB1, SHC1, PTEN, PTK2, PTK6, | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate, 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate, 1D-myo-inositol 1,3,4,5-tetrakisphosphate, 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate, 1-phosphatidyl-1D-myo-inositol 3-phosphate, |
| Protein substrates in this pathway |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:16618 | C05981 | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate |  | TNS2, FIG4, INPP5B, INPP5E, INPP5K, OCRL, PTEN, PTPRQ, INPP5F, INPP5D, INPPL1, SYNJ1, SYNJ2, TPTE2, |