Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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KEGG Pathway - Endocytosis - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| DNAJC6 | O75061 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| VPS29 | Q9UBQ0 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| WASL | O00401 | PTPN2, |
| STAM2 | O75886 | PTPN1, |
| EGFR | P00533 | CDC25A, ACP1, PTPN1, PTPN9, PTPRU, PTPRJ, PTPRK, PTPRS, PTPN6, PTPN11, PTPN2, DUSP3, UBASH3B, PTPRA, PTPRB, PTPN12, PTPRH, |
| IGF1R | P08069 | PTPN1, |
| SRC | P12931 | PTPN23, ACP1, PPP2CA, PPP2CB, PTPN1, PTPN21, PTPN12, PTPRA, PTPRE, PTPRJ, PTPRH, PTPN6, PTPN11, PTPN2, |
| FGFR2 | P21802 | DUSP3, |
| CBL | P22681 | PTPRJ, UBASH3B, |
| TGFBR1 | P36897 | PPP1CC, PPP1CA, PPP1CB, |
| PRKCI | P41743 | PPP2CA, PPP2CB, |
| WAS | P42768 | PTPN12, |
| DNM2 | P50570 | PPP3CA, PPP3CB, PPP3CC, |
| SMAD3 | P84022 | MTMR4, PPP2CA, PPP2CB, PPM1A, CTDSP1, CTDSP2, CTDSPL, |
| MDM2 | Q00987 | PPP2CA, PPP2CB, PPM1D, |
| CAV1 | Q03135 | PTPN1, PTPN2, |
| DNM1 | Q05193 | PPP3CA, PPP3CB, PPP3CC, |
| SMAD2 | Q15796 | PPM1A, CTDSP1, CTDSP2, CTDSPL, |
| PARD3 | Q8TEW0 | PPP1CA, PTPRK, |
| EPS15 | P42566 | PTPN3, |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:17283 | C04549 | 1-phosphatidyl-1D-myo-inositol 3-phosphate |  | MTM1, MTMR1, MTMR14, MTMR2, MTMR3, MTMR4, MTMR6, MTMR7, PTEN, PTPRQ, SACM1L, |
| CHEBI:18348 | C04637 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate |  | FIG4, INPP5B, INPP5E, INPP5J, INPP5K, OCRL, PTP4A3, PTPRQ, INPP5F, SYNJ1, SYNJ2, |
| CHEBI:16618 | C05981 | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate |  | TNS2, FIG4, INPP5B, INPP5E, INPP5K, OCRL, PTEN, PTPRQ, INPP5F, INPP5D, INPPL1, SYNJ1, SYNJ2, TPTE2, |
| CHEBI:16851 | C11556 | 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate |  | FIG4, MTM1, MTMR1, MTMR14, MTMR2, MTMR3, MTMR6, MTMR7, PTEN, PTPRQ, INPPL1, TPTE2, |