Top MTMR6
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-1660499 Synthesis of PIPs at the plasma membrane. At the plasma membrane, subsequent phosphorylation of phosphatidylinositol 4-phosphate (PI4P) produces phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) while the actions of various other kinases and phosphatases produces phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 5-phosphate (PI5P), phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (Zhang et al. 1997, Gurung et al. 2003, Guo et al. 1999, Vanhaesebroeck et al. 1997, Tolias et al. 1998, Schaletzky et al. 2003, Kim et al. 2002, Clarke et al. 2010). Many of the phosphatidylinositol phosphatases that act at the plasma membrane belong to the myotubularin family. Enzymatically inactive myotubularin family members can heterodimerize with catalytically active mytotubularins to regulate their stability, activity and/or substrate specificity (Berger et al. 2006, Zou et al. 2012)
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source AMOTL2 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct BBS7 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID BHMT Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CARM1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CDA Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CEP170 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP19 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CTSE Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ELAVL1 Affinity Capture-RNA physical 19322201 , (Europe PMC )NA BioGRID ERBB3 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB4 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID FHIT Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID HIP1R Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID IFI30 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID KCNJ5 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID KCTD17 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID LMTK2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID MTMR6 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MTMR7 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MTMR9 Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Proximity Label-MS, Reconstituted Complex, Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 12890864 , 21516116 , 25416956 , 26344197 , 27880917 , 28514442 , Europe PMC )0.76 BioGRID, IntAct, MINT MTNR1B Two-hybrid, two hybrid physical, physical association 26514267 , (Europe PMC )0.37 BioGRID, IntAct MTUS2 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct NMI Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct PTK7 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID RARG Two-hybrid, two hybrid array physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct ROR2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID RPL34 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SOAT1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID STIL Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct STK25 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID TMEM17 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct TRIM27 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct ZWINT Affinity Capture-MS physical 26186194 , 27432908 , 28514442 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source AMOTL2 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct BCL6 anti bait coimmunoprecipitation association 16147992 , (Europe PMC )0.35 IntAct CEP170 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP19 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct MTMR9 Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Proximity Label-MS, Reconstituted Complex, Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 12890864 , 21516116 , 25416956 , 26344197 , 27880917 , 28514442 , Europe PMC )0.76 BioGRID, IntAct, MINT MTNR1B Two-hybrid, two hybrid physical, physical association 26514267 , (Europe PMC )0.37 BioGRID, IntAct MTUS2 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct NMI Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct RARG Two-hybrid, two hybrid array physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct STIL Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct TGOLN2 proximity-dependent biotin identification association 29568061 , (Europe PMC )0.35 IntAct TMEM17 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct TRIM27 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ALKBH4 two hybrid physical association 23145062 , (Europe PMC )0.37 IntAct AMOTL2 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct BBS7 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID BCL6 anti bait coimmunoprecipitation association 16147992 , (Europe PMC )0.35 IntAct BHMT Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CARM1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CDA Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CEP170 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP19 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CTSE Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ELAVL1 Affinity Capture-RNA physical 19322201 , (Europe PMC )NA BioGRID ERBB3 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB4 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID FHIT Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID HIP1R Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID IFI30 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID KCNJ5 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID KCTD17 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID LMTK2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID MTMR6 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MTMR7 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MTMR9 Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Proximity Label-MS, Reconstituted Complex, Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 12890864 , 21516116 , 25416956 , 26344197 , 27880917 , 28514442 , Europe PMC )0.76 BioGRID, IntAct, MINT MTNR1B Two-hybrid, two hybrid physical, physical association 26514267 , (Europe PMC )0.37 BioGRID, IntAct MTUS2 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct NMI Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct PTK7 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID RARG Two-hybrid, two hybrid array physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct ROR2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID RPL34 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SOAT1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID STIL Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct STK25 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID TGOLN2 proximity-dependent biotin identification association 29568061 , (Europe PMC )0.35 IntAct TMEM17 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct TRIM27 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct ZWINT Affinity Capture-MS physical 26186194 , 27432908 , 28514442 , (Europe PMC )NA BioGRID
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