Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
DEPOD - Phosphatase Search Result
Search results for Historic class - Classical PTPs
Download FASTA sequences in txt format
| Entry name | UniProt AC | Historic Class | SCOP Fold | EC number | CATH ID | Superfamily | Family | Activity status |
| PTPN1 | P18031 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN11 | Q06124 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN12 | Q05209 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN13 | Q12923 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN14 | Q15678 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN18 | Q99952 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN2 | P17706 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN20 | Q4JDL3 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | NA | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN21 | Q16825 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN22 | Q9Y2R2 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN23 | Q9H3S7 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN3 | P26045 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN4 | P29074 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN5 | P54829 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN6 | P29350 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN7 | P35236 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN9 | P43378 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPRA | P18433 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRB | P23467 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRC | P08575 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRD | P23468 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRE | P23469 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRF | P10586 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRG | P23470 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRH | Q9HD43 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRJ | Q12913 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRK | Q15262 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRM | P28827 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRN | Q16849 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | NA | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | inactive |
| PTPRN2 | Q92932 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRO | Q16827 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRQ | Q9UMZ3 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.-, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRR | Q15256 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRS | Q13332 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRT | O14522 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRU | Q92729 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRZ1 | P23471 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |