Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
299 KEGG pathways;
876 Reactome pathways;
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023




Gene Name PTPRN (QuickGO)
Interactive visualization PTPRN structures
(A quick tutorial to explore the interctive visulaization)

Synonyms PTPRN, ICA3, ICA512
Protein Name PTPRN
Alternative Name(s)
Receptor-type tyrosine-protein phosphatase-like N;R-PTP-N;Islet cell antigen 512;ICA 512;Islet cell autoantigen 3;PTP IA-2;ICA512-N-terminal fragment;ICA512-NTF;ICA512-transmembrane fragment;ICA512-TMF;ICA512-cleaved cytosolic fragment;ICA512-CCF;
EntrezGene ID5798   (Comparitive Toxicogenomics)
UniProt AC (Human) Q16849 (protein sequence)
Enzyme ClassN/A
Molecular Weight105848 Dalton
Protein Length979 amino acids (AA)
Genome Browsers NCBI | ENSG00000054356 (Ensembl) | UCSC
Crosslinking annotations Query our ID-mapping table
Orthologues Quest For Orthologues (QFO) | GeneTree
Classification Superfamily: Class I Cys-based PTPs --> Family: R-PTP | Historic class: Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CATH ID: | SCOP Fold: CC1
Phosphatase activityinactive | Catalytic signature motif: HCSDGAGR
Domain organization, Expression, Diseases(show / hide)
Localization, Function, Catalytic activity and Sequence(show / hide)
Motif information from Eukaryotic Linear Motif atlas (ELM)(show / hide)
Gene Ontology (P: Process; F: Function and C: Component terms)(show / hide)