Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
DEPOD - Phosphatase Search Result
Search results for Historic class - VH1-like or DSPs
Download FASTA sequences in txt format
| Entry name | UniProt AC | Historic Class | SCOP Fold | EC number | CATH ID | Superfamily | Family | Activity status |
| CDC14A | Q9UNH5 | Class I Cys-based PTPs --> VH1-like or DSPs --> CDC14s | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| CDC14B | O60729 | Class I Cys-based PTPs --> VH1-like or DSPs --> CDC14s | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| CDC14C | A4D256 | Class I Cys-based PTPs --> VH1-like or DSPs --> CDC14s | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| CDKN3 | Q16667 | Class I Cys-based PTPs --> VH1-like or DSPs --> CDC14s | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DNAJC6 | O75061 | Class I Cys-based PTPs --> VH1-like or DSPs --> PTENs | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUPD1 | Q68J44 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP1 | P28562 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP10 | Q9Y6W6 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP11 | O75319 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.- | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP12 | Q9UNI6 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP13 | Q9UII6 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP13 | Q6B8I1 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP14 | O95147 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP15 | Q9H1R2 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP16 | Q9BY84 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP18 | Q8NEJ0 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP19 | Q8WTR2 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP2 | Q05923 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP21 | Q9H596 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP22 | Q9NRW4 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP23 | Q9BVJ7 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP26 | Q9BV47 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP28 | Q4G0W2 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP3 | P51452 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP4 | Q13115 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP5 | Q16690 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP6 | Q16828 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP7 | Q16829 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP8 | Q13202 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP9 | Q99956 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| EPM2A | O95278 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| FAN1 | Q9Y2M0 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | NA | NA | NA | NA | NA | inactive |
| MTM1 | Q13496 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | 3.1.3.64 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| MTMR1 | Q13613 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | 3.1.3.- | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| MTMR10 | Q9NXD2 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | NA | NA | Class I Cys-based PTPs | DSP | inactive |
| MTMR11 | A4FU01 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | NA | NA | Class I Cys-based PTPs | DSP | inactive |
| MTMR12 | Q9C0I1 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | NA | NA | Class I Cys-based PTPs | DSP | inactive |
| MTMR14 | Q8NCE2 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | 3.1.3.- | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| MTMR2 | Q13614 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | 3.1.3.- | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| MTMR3 | Q13615 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| MTMR4 | Q9NYA4 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| MTMR6 | Q9Y217 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | 3.1.3.- | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| MTMR7 | Q9Y216 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | 3.1.3.- | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| MTMR8 | Q96EF0 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | 3.1.3.- | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| MTMR9 | Q96QG7 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | NA | NA | Class I Cys-based PTPs | DSP | inactive |
| PTEN | P60484 | Class I Cys-based PTPs --> VH1-like or DSPs --> PTENs | CC1 | 3.1.3.16, 3.1.3.48, 3.1.3.67 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| PTP4A1 | Q93096 | Class I Cys-based PTPs --> VH1-like or DSPs --> PRLs | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| PTP4A2 | Q12974 | Class I Cys-based PTPs --> VH1-like or DSPs --> PRLs | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| PTP4A3 | O75365 | Class I Cys-based PTPs --> VH1-like or DSPs --> PRLs | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| PTPDC1 | A2A3K4 | Class I Cys-based PTPs --> VH1-like or DSPs --> CDC14s | CC1 | 3.1.3.- | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| PTPMT1 | Q8WUK0 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| RNGTT | O60942 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.33, 2.7.7.50 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| SBF1 | O95248 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | NA | NA | Class I Cys-based PTPs | DSP | inactive |
| SBF2 | Q86WG5 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | NA | NA | Class I Cys-based PTPs | DSP | inactive |
| SSH1 | Q8WYL5 | Class I Cys-based PTPs --> VH1-like or DSPs --> Slingshots | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| SSH2 | Q76I76 | Class I Cys-based PTPs --> VH1-like or DSPs --> Slingshots | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| SSH3 | Q8TE77 | Class I Cys-based PTPs --> VH1-like or DSPs --> Slingshots | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| STYX | Q8WUJ0 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | NA | 3.90.190.10 | Class I Cys-based PTPs | DSP | inactive |
| STYXL1 | Q9Y6J8 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | NA | 3.90.190.10 | Class I Cys-based PTPs | DSP | inactive |
| TNS1 | Q9HBL0 | Class I Cys-based PTPs --> VH1-like or DSPs --> PTENs | CC1 | NA | 3.90.190.10 | Class I Cys-based PTPs | DSP | inactive |
| TNS2 | Q63HR2 | Class I Cys-based PTPs --> VH1-like or DSPs --> PTENs | CC1 | 3.1.3.- | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| TPTE | P56180 | Class I Cys-based PTPs --> VH1-like or DSPs --> PTENs | CC1 | 3.1.3.67 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| TPTE2 | Q6XPS3 | Class I Cys-based PTPs --> VH1-like or DSPs --> PTENs | CC1 | 3.1.3.67 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |