Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
last update: 18 Feb, 2016


Pathways involving human phosphatases and their substrates

Pathway ID Pathway Name (KEGG Pathway)
hsa00010Glycolysis / Gluconeogenesis
hsa00020Citrate cycle (TCA cycle)
hsa00030Pentose phosphate pathway
hsa00040Pentose and glucuronate interconversions
hsa00051Fructose and mannose metabolism
hsa00052Galactose metabolism
hsa00100Steroid biosynthesis
hsa00190Oxidative phosphorylation
hsa00230Purine metabolism
hsa00240Pyrimidine metabolism
hsa00250Alanine, aspartate and glutamate metabolism
hsa00260Glycine, serine and threonine metabolism
hsa00270Cysteine and methionine metabolism
hsa00280Valine, leucine and isoleucine degradation
hsa00290Valine, leucine and isoleucine biosynthesis
hsa00310Lysine degradation
hsa00330Arginine and proline metabolism
hsa00410beta-Alanine metabolism
hsa00430Taurine and hypotaurine metabolism
hsa00500Starch and sucrose metabolism
hsa00520Amino sugar and nucleotide sugar metabolism
hsa00524Butirosin and neomycin biosynthesis
hsa00534Glycosaminoglycan biosynthesis - heparan sulfate
hsa00561Glycerolipid metabolism
hsa00562Inositol phosphate metabolism
hsa00564Glycerophospholipid metabolism
hsa00565Ether lipid metabolism
hsa00590Arachidonic acid metabolism
hsa00600Sphingolipid metabolism
hsa00620Pyruvate metabolism
hsa00630Glyoxylate and dicarboxylate metabolism
hsa00650Butanoate metabolism
hsa00730Thiamine metabolism
hsa00740Riboflavin metabolism
hsa00750Vitamin B6 metabolism
hsa00760Nicotinate and nicotinamide metabolism
hsa00770Pantothenate and CoA biosynthesis
hsa00790Folate biosynthesis
hsa00900Terpenoid backbone biosynthesis
hsa00920Sulfur metabolism
hsa00970Aminoacyl-tRNA biosynthesis
hsa01100Metabolic pathways
hsa03013RNA transport
hsa03015mRNA surveillance pathway
hsa03020RNA polymerase
hsa03030DNA replication
hsa03320PPAR signaling pathway
hsa03410Base excision repair
hsa03420Nucleotide excision repair
hsa03430Mismatch repair
hsa03440Homologous recombination
hsa03450Non-homologous end-joining
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04020Calcium signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04080Neuroactive ligand-receptor interaction
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04115p53 signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa04140Regulation of autophagy
hsa04141Protein processing in endoplasmic reticulum
hsa04150mTOR signaling pathway
hsa04260Cardiac muscle contraction
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04320Dorso-ventral axis formation
hsa04340Hedgehog signaling pathway
hsa04350TGF-beta signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04514Cell adhesion molecules (CAMs)
hsa04520Adherens junction
hsa04530Tight junction
hsa04540Gap junction
hsa04612Antigen processing and presentation
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04710Circadian rhythm - mammal
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04740Olfactory transduction
hsa04742Taste transduction
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04920Adipocytokine signaling pathway
hsa04930Type II diabetes mellitus
hsa04940Type I diabetes mellitus
hsa04950Maturity onset diabetes of the young
hsa04960Aldosterone-regulated sodium reabsorption
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04962Vasopressin-regulated water reabsorption
hsa04966Collecting duct acid secretion
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04973Carbohydrate digestion and absorption
hsa04974Protein digestion and absorption
hsa04975Fat digestion and absorption
hsa04976Bile secretion
hsa04977Vitamin digestion and absorption
hsa04978Mineral absorption
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05016Huntington's disease
hsa05020Prion diseases
hsa05100Bacterial invasion of epithelial cells
hsa05110Vibrio cholerae infection
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05130Pathogenic Escherichia coli infection
hsa05132Salmonella infection
hsa05142Chagas disease (American trypanosomiasis)
hsa05143African trypanosomiasis
hsa05150Staphylococcus aureus infection
hsa05160Hepatitis C
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05168Herpes simplex infection
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa05216Thyroid cancer
hsa05217Basal cell carcinoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
hsa05322Systemic lupus erythematosus
hsa05323Rheumatoid arthritis
hsa05340Primary immunodeficiency
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05416Viral myocarditis
ko00240 Pyrimidine metabolism
ko00500 Starch and sucrose metabolism
ko00521 Streptomycin biosynthesis
ko00523 Polyketide sugar unit biosynthesis
ko00540 Lipopolysaccharide biosynthesis
ko00550 Peptidoglycan biosynthesis
ko00680 Methane metabolism
ko00710 Carbon fixation in photosynthetic organisms
ko00906 Carotenoid biosynthesis
ko00908 Zeatin biosynthesis
ko00909 Sesquiterpenoid biosynthesis
ko00981 Insect hormone biosynthesis
ko01057 Biosynthesis of type II polyketide products
ko01100 Metabolic pathways
ko01110 Biosynthesis of secondary metabolites
ko01120 Microbial metabolism in diverse environments
ko02010 ABC transporters
ko02060 Phosphotransferase system (PTS)
ko04010 MAPK signaling pathway
ko04745 Phototransduction - fly
ko04810 Regulation of actin cytoskeleton
ko05132 Salmonella infection
ko05133 Pertussis
ko05134 Legionellosis
ko05152 Tuberculosis
ko05332 Graft-versus-host disease
map01060Biosynthesis of plant secondary metabolites
map01061Biosynthesis of phenylpropanoids
map01062Biosynthesis of terpenoids and steroids
map01063Biosynthesis of alkaloids derived from shikimate pathway
map01064Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
map01065Biosynthesis of alkaloids derived from histidine and purine
map01066Biosynthesis of alkaloids derived from terpenoid and polyketide
map01070Biosynthesis of plant hormones
Pathway ID Pathway Name (Reactome Pathway)
REACT_121388Abacavir metabolism
REACT_6261Abortive elongation of HIV-1 transcript in the absence of Tat
REACT_18405Acetylcholine regulates insulin secretion
REACT_120863Activated point mutants of FGFR2
REACT_21399activated TAK1 mediates p38 MAPK activation
REACT_707Activation and oligomerization of BAK protein
REACT_6769Activation of ATR in response to replication stress
REACT_549Activation of BAD and translocation to mitochondria
REACT_1650Activation of BIM and translocation to mitochondria
REACT_2100Activation of BMF and translocation to mitochondria
REACT_20652Activation of CaMK IV
REACT_607Activation of caspases through apoptosome-mediated cleavage
REACT_13462Activation of DNA fragmentation factor
REACT_75831Activation of G protein gated Potassium channels
REACT_25148Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
REACT_118656Activation of NF-kappaB in B cells
REACT_160122Activation of NIMA Kinases NEK9, NEK6, NEK7
REACT_1194Activation of NOXA and translocation to mitochondria
REACT_790Activation of PKB
REACT_790Activation of PKB
REACT_200686Activation of PPARGC1A (PGC-1alpha) by phosphorylation
REACT_121Activation of PUMA and translocation to mitochondria
REACT_19226Activation of Rac
REACT_21326Activation of the AP-1 family of transcription factors
REACT_163932Activation of the phototransduction cascade
REACT_1095Activation of the pre-replicative complex
REACT_1095Activation of the pre-replicative complex
REACT_701Activation, myristolyation of BID and translocation to mitochondria
REACT_584Activation, translocation and oligomerization of BAX
REACT_19195Adherens junctions interactions
REACT_19140ADP signalling through P2Y purinoceptor 1
REACT_20653ADP signalling through P2Y purinoceptor 12
REACT_18339Adrenaline,noradrenaline inhibits insulin secretion
REACT_25195Advanced glycosylation endproduct receptor signaling
REACT_12564AKT phosphorylates targets in the cytosol
REACT_12442AKT phosphorylates targets in the nucleus
REACT_13655AKT-mediated inactivation of FOXO1A
REACT_118700Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
REACT_75795Antigen Presentation: Folding, assembly and peptide loading of class I MHC
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_6820APC/C:Cdc20 mediated degradation of Cyclin B
REACT_6761APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
REACT_13579Apoptotic cleavage of cell adhesion proteins
REACT_107Apoptotic cleavage of cellular proteins
REACT_995Apoptotic execution phase
REACT_12002ARMS-mediated activation
REACT_486Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
REACT_2141Assembly of the RAD51-ssDNA nucleoprotein complex
REACT_6277Assembly of Viral Components at the Budding Site
REACT_16907Association of TriC/CCT with target proteins during biosynthesis
REACT_1924ATM mediated phosphorylation of repair proteins
REACT_204ATM mediated response to DNA double-strand break
REACT_200624Attenuation phase
REACT_25325AUF1 (hnRNP D0) destabilizes mRNA
REACT_6785Autodegradation of Cdh1 by Cdh1:APC/C
REACT_20549Autodegradation of the E3 ubiquitin ligase COP1
REACT_12560Basigin interactions
REACT_11065Beta-catenin phosphorylation cascade
REACT_330BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACT_19298Bicarbonate transporters
REACT_200799binding of TCF/LEF:CTNNB1 to target gene promoters
REACT_111118BMAL1:CLOCK,NPAS2 activates circadian gene expression
REACT_197Branched-chain amino acid catabolism
REACT_13472Breakdown of the nuclear lamina
REACT_24915Butyrate Response Factor 1 (BRF1) destabilizes mRNA
REACT_11043c-src mediated regulation of Cx43 function and closure of gap junctions
REACT_75896Ca2+ activated K+ channels
REACT_172761Ca2+ pathway
REACT_9000Calmodulin induced events
REACT_9000Calmodulin induced events
REACT_23810Calnexin/calreticulin cycle
REACT_15502CaMK IV-mediated phosphorylation of CREB
REACT_15502CaMK IV-mediated phosphorylation of CREB
REACT_1503Caspase-8 activation
REACT_13541Caspase-mediated cleavage of cytoskeletal proteins
REACT_19183CD28 co-stimulation
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_19238CD28 dependent Vav1 pathway
REACT_1221CDK-mediated phosphorylation and removal of Cdc6
REACT_1221CDK-mediated phosphorylation and removal of Cdc6
REACT_21402CDO in myogenesis
REACT_12051Cell surface interactions at the vascular wall
REACT_20649Cell-extracellular matrix interactions
REACT_407Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
REACT_22292CHL1 interactions
REACT_2122ChREBP activates metabolic gene expression
REACT_24941Circadian Clock
REACT_18372Class B/2 (Secretin family receptors)
REACT_18319Class C/3 (Metabotropic glutamate/pheromone receptors)
REACT_160251Clearance of Nuclear Envelope Membranes from Chromatin
REACT_150260Condensation of Prometaphase Chromosomes
REACT_172744Condensation of Prophase Chromosomes
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_6867Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
REACT_19344Costimulation by the CD28 family
REACT_12524CREB phosphorylation
REACT_12524CREB phosphorylation
REACT_20625CREB phosphorylation through the activation of Adenylate Cyclase
REACT_20642CREB phosphorylation through the activation of CaMKII
REACT_20661CREB phosphorylation through the activation of CaMKK
REACT_20568CREB phosphorylation through the activation of Ras
REACT_19199CRMPs in Sema3A signaling
REACT_111174Cross-presentation of particulate exogenous antigens (phagosomes)
REACT_19405CTLA4 inhibitory signaling
REACT_1857Cyclin A/B1 associated events during G2/M transition
REACT_9029Cyclin A:Cdk2-associated events at S phase entry
REACT_2101Cyclin B2 mediated events
REACT_821Cyclin D associated events in G1
REACT_1574Cyclin E associated events during G1/S transition
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_6913Cytosolic sulfonation of small molecules
REACT_111064DAG and IP3 signaling
REACT_147814DAP12 signaling
REACT_15334DARPP-32 events
REACT_22351DCC mediated attractive signaling
REACT_200731deactivation of the beta-catenin transactivating complex
REACT_200766degradation of AXIN
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_118572Degradation of the extracellular matrix
REACT_200828Depolymerisation of the Nuclear Lamina
REACT_22186Deposition of new CENPA-containing nucleosomes at the centromere
REACT_163773DEx/H-box helicases activate type I IFN and inflammatory cytokines production
REACT_832Dimerization of procaspase-8
REACT_200610disassembly of the destruction complex and recruitment of AXIN to the membrane
REACT_1178Disinhibition of SNARE formation
REACT_169185DNA Damage/Telomere Stress Induced Senescence
REACT_115662Downregulation of ERBB2:ERBB3 signaling
REACT_115828Downregulation of ERBB4 signaling
REACT_121111Downregulation of SMAD2/3:SMAD4 transcriptional activity
REACT_120727Downregulation of TGF-beta receptor signaling
REACT_17025Downstream signal transduction
REACT_12555Downstream TCR signaling
REACT_25299DSCAM interactions
REACT_311Dual incision reaction in GG-NER
REACT_2222Dual incision reaction in TC-NER
REACT_471E2F mediated regulation of DNA replication
REACT_1321E2F-enabled inhibition of pre-replication complex formation
REACT_163906ECM proteoglycans
REACT_2202Effects of PIP2 hydrolysis
REACT_12484EGFR downregulation
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_121096EGFR Transactivation by Gastrin
REACT_150366Elastic fibre formation
REACT_27258Endosomal Sorting Complex Required For Transport (ESCRT)
REACT_12477eNOS activation
REACT_12599ERK/MAPK targets
REACT_12599ERK/MAPK targets
REACT_1391ERK1 activation
REACT_1391ERK1 activation
REACT_1183ERK2 activation
REACT_1183ERK2 activation
REACT_12436ERKs are inactivated
REACT_12436ERKs are inactivated
REACT_121329Erythrocytes take up carbon dioxide and release oxygen
REACT_121380Erythrocytes take up oxygen and release carbon dioxide
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_18410Fanconi Anemia pathway
REACT_900FasL/ CD95L signaling
REACT_1319Fatty Acyl-CoA Biosynthesis
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163834FCERI mediated Ca+2 mobilization
REACT_163701FCERI mediated MAPK activation
REACT_163994FCERI mediated NF-kB activation
REACT_160274FCGR activation
REACT_9416FGFR2b ligand binding and activation
REACT_9413FGFR2c ligand binding and activation
REACT_160131Fibronectin matrix formation
REACT_11049Formation of annular gap junctions
REACT_89Formation of apoptosome
REACT_22201Formation of HIV elongation complex in the absence of HIV Tat
REACT_6346Formation of HIV-1 elongation complex containing HIV-1 Tat
REACT_257Formation of incision complex in GG-NER
REACT_1845Formation of RNA Pol II elongation complex
REACT_169121Formation of Senescence-Associated Heterochromatin Foci (SAHF)
REACT_200753formation of the beta-catenin:TCF transactivating complex
REACT_846Formation of the Early Elongation Complex
REACT_6319Formation of the HIV-1 Early Elongation Complex
REACT_1079Formation of the ternary complex, and subsequently, the 43S complex
REACT_1941Formation of transcription-coupled NER (TC-NER) repair complex
REACT_12076Frs2-mediated activation
REACT_21247FRS2-mediated cascade
REACT_18407G alpha (12/13) signalling events
REACT_19231G alpha (i) signalling events
REACT_18283G alpha (q) signalling events
REACT_18283G alpha (q) signalling events
REACT_19327G alpha (s) signalling events
REACT_19333G alpha (z) signalling events
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_19145G beta:gamma signalling through PLC beta
REACT_15457G-protein activation
REACT_111214G0 and Early G1
REACT_683G1/S-Specific Transcription
REACT_1915G2 Phase
REACT_897G2/M DNA damage checkpoint
REACT_1846G2/M DNA replication checkpoint
REACT_12578GAB1 signalosome
REACT_24020GABA synthesis
REACT_23947GABA synthesis, release, reuptake and degradation
REACT_11035Gap junction degradation
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_12623Generation of second messenger molecules
REACT_1665Glucagon signaling in metabolic regulation
REACT_18274Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REACT_18377Glucagon-type ligand receptors
REACT_212Glucose transport
REACT_169208Glycogen synthesis
REACT_116105Glycosphingolipid metabolism
REACT_19400Golgi Associated Vesicle Biogenesis
REACT_1100Golgi Cisternae Pericentriolar Stack Reorganization
REACT_23847GP1b-IX-V activation signalling
REACT_1695GPVI-mediated activation cascade
REACT_12606GRB2 events in EGFR signaling
REACT_115854GRB2 events in ERBB2 signaling
REACT_15443GRB2:SOS provides linkage to MAPK signaling for Integrins
REACT_115896GRB7 events in ERBB2 signaling
REACT_111133Growth hormone receptor signaling
REACT_2085GTP hydrolysis and joining of the 60S ribosomal subunit
REACT_172610HATs acetylate histones
REACT_6259HIV elongation arrest and recovery
REACT_6332HIV Transcription Initiation
REACT_494Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
REACT_200744HSF1 activation
REACT_200775HSF1-dependent transactivation
REACT_25218HuR stabilizes mRNA
REACT_25374IKK complex recruitment mediated by RIP1
REACT_11152Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
REACT_163919Inactivation, recovery and regulation of the phototransduction cascade
REACT_25004Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
REACT_6350Inhibition of PKR
REACT_329Inhibition of replication initiation of damaged DNA by RB1/E2F1
REACT_6743Inhibition of TSC complex formation by PKB
REACT_6743Inhibition of TSC complex formation by PKB
REACT_160242Initiation of Nuclear Envelope Reformation
REACT_1109Insulin receptor recycling
REACT_1505Integration of energy metabolism
REACT_15523Integrin alphaIIb beta3 signaling
REACT_13552Integrin cell surface interactions
REACT_6905Interactions of Tat with host cellular proteins
REACT_25162Interferon alpha/beta signaling
REACT_25078Interferon gamma signaling
REACT_23891Interleukin receptor SHC signaling
REACT_23891Interleukin receptor SHC signaling
REACT_23950Interleukin-1 processing
REACT_22442Interleukin-1 signaling
REACT_27283Interleukin-2 signaling
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_27307Interleukin-6 signaling
REACT_115529Interleukin-7 signaling
REACT_24918IRAK1 recruits IKK complex
REACT_24918IRAK1 recruits IKK complex
REACT_25354IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
REACT_25380IRAK2 mediated activation of TAK1 complex
REACT_25380IRAK2 mediated activation of TAK1 complex
REACT_25018IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
REACT_163993IRF3-mediated induction of type I IFN
REACT_570IRS activation
REACT_150203IRS-related events triggered by IGF1R
REACT_115831ISG15 antiviral mechanism
REACT_21368JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
REACT_25042KSRP destabilizes mRNA
REACT_79L13a-mediated translational silencing of Ceruloplasmin expression
REACT_22205L1CAM interactions
REACT_169262Laminin interactions
REACT_1838Leading Strand Synthesis
REACT_20617Localization of the PINCH-ILK-PARVIN complex to focal adhesions
REACT_15364Loss of Nlp from mitotic centrosomes
REACT_15451Loss of proteins required for interphase microtubule organization from the centrosome
REACT_163743LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
REACT_19287Lysosome Vesicle Biogenesis
REACT_150182MASTL Facilitates Mitotic Progression
REACT_27271Meiotic recombination
REACT_75792Meiotic synapsis
REACT_962MEK activation
REACT_75881Methionine salvage pathway
REACT_121399MHC class II antigen presentation
REACT_12417MicroRNA (miRNA) biogenesis
REACT_1016Mitotic Metaphase/Anaphase Transition
REACT_682Mitotic Prometaphase
REACT_1932Mitotic Telophase/Cytokinesis
REACT_150331Molecules associated with elastic fibres
REACT_1884MRN complex relocalizes to nuclear foci
REACT_1470mRNA Capping
REACT_467mRNA Splicing - Major Pathway
REACT_1753mRNA Splicing - Minor Pathway
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_200783Myoclonic epilepsy of Lafora
REACT_13526NADE modulates death signalling
REACT_18334NCAM signaling for neurite out-growth
REACT_11068Nef and signal transduction
REACT_11166Nef Mediated CD4 Down-regulation
REACT_11103Nef mediated downregulation of MHC class I complex cell surface expression
REACT_111184Negative regulation of FGFR signaling
REACT_12447Negative regulation of the PI3K/AKT network
REACT_23832Nephrin interactions
REACT_22384Netrin mediated repulsion signals
REACT_22237Netrin-1 signaling
REACT_12473Neurophilin interactions with VEGF and VEGFR
REACT_25039NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
REACT_13696NF-kB is activated and signals survival
REACT_11046NGF-independant TRKA activation
REACT_23862Nitric oxide stimulates guanylate cyclase
REACT_75776NOD1/2 Signaling Pathway
REACT_1022Nonhomologous End-joining (NHEJ)
REACT_75822Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
REACT_200856NoRC negatively regulates rRNA expression
REACT_12510NOSIP mediated eNOS trafficking
REACT_12541NOSTRIN mediated eNOS trafficking
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_163910NOTCH2 intracellular domain regulates transcription
REACT_13638NRAGE signals death through JNK
REACT_13643NRIF signals cell death from the nucleus
REACT_163931Nuclear Pore Complex (NPC) Disassembly
REACT_15525Nuclear Receptor transcription pathway
REACT_116022Nuclear signaling by ERBB4
REACT_15488Olfactory Signaling Pathway
REACT_169325Oncogene Induced Senescence
REACT_1156Orc1 removal from chromatin
REACT_1156Orc1 removal from chromatin
REACT_19200Other semaphorin interactions
REACT_169436Oxidative Stress Induced Senescence
REACT_15381p130Cas linkage to MAPK signaling for integrins
REACT_12065p38MAPK events
REACT_1625p53-Dependent G1 DNA Damage Response
REACT_2160p53-Independent DNA Damage Response
REACT_13695p75NTR negatively regulates cell cycle via SC1
REACT_13415p75NTR recruits signalling complexes
REACT_7963Packaging Of Telomere Ends
REACT_6244Pausing and recovery of HIV elongation
REACT_6143Pausing and recovery of Tat-mediated HIV elongation
REACT_19324PD-1 signaling
REACT_1451PDE3B signalling
REACT_1451PDE3B signalling
REACT_12519PECAM1 interactions
REACT_1404Peptide chain elongation
REACT_18277PERK regulates gene expression
REACT_121256Phagosomal maturation (early endosomal stage)
REACT_15466phospho-PLA2 pathway
REACT_21310Phospholipase C-mediated cascade
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_6875Phosphorylation of Emi1
REACT_308Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
REACT_6362Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
REACT_6904Phosphorylation of the APC/C
REACT_21270PI-3K cascade
REACT_976PI3K Cascade
REACT_976PI3K Cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_12464PI3K/AKT activation
REACT_75829PIP3 activates AKT signaling
REACT_15530PKA activation
REACT_15530PKA activation
REACT_1946PKA activation in glucagon signalling
REACT_15497PKA-mediated phosphorylation of CREB
REACT_15497PKA-mediated phosphorylation of CREB
REACT_1525PKA-mediated phosphorylation of key metabolic factors
REACT_1230Platelet Adhesion to exposed collagen
REACT_318Platelet degranulation
REACT_23879Platelet sensitization by LDL
REACT_12079PLC-gamma1 signalling
REACT_115720PLCG1 events in ERBB2 signaling
REACT_1006Polo-like kinase mediated events
REACT_1792Polymerase switching
REACT_7987Polymerase switching on the C-strand of the telomere
REACT_200759POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
REACT_705PP2A-mediated dephosphorylation of key metabolic factors
REACT_116145PPARA activates gene expression
REACT_200808PRC2 methylates histones and DNA
REACT_118568Pre-NOTCH Transcription and Translation
REACT_21254Presynaptic function of Kainate receptors
REACT_408Presynaptic phase of homologous DNA pairing and strand exchange
REACT_125Processing of Capped Intron-Containing Pre-mRNA
REACT_2055Processing of DNA double-strand break ends
REACT_1201Processing of DNA ends prior to end rejoining
REACT_8027Processive synthesis on the C-strand of the telomere
REACT_1385Processive synthesis on the lagging strand
REACT_115697Prolactin receptor signaling
REACT_23946Prostacyclin signalling through prostacyclin receptor
REACT_2086Purine catabolism
REACT_21376Pyrimidine biosynthesis
REACT_1023Pyrimidine catabolism
REACT_2071Pyruvate metabolism
REACT_2077RAF activation
REACT_614RAF phosphorylates MEK
REACT_23898Rap1 signalling
REACT_20546Ras activation uopn Ca2+ infux through NMDA receptor
REACT_15296Recruitment of mitotic centrosome proteins and complexes
REACT_15510Recruitment of NuMA to mitotic centrosomes
REACT_97Recruitment of repair and signaling proteins to double-strand breaks
REACT_11042Recycling of bile acids and salts
REACT_1815Recycling of eIF2:GDP
REACT_22365Recycling pathway of L1
REACT_13443Regulated proteolysis of p75NTR
REACT_164011Regulation by c-FLIP
REACT_160086Regulation of actin dynamics for phagocytic cup formation
REACT_13464Regulation of activated PAK-2p34 by proteasome mediated degradation
REACT_21285Regulation of AMPK activity via LKB1
REACT_6837Regulation of APC/C activators between G1/S and early anaphase
REACT_20580Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
REACT_13819Regulation of gene expression in beta cells
REACT_6804Regulation of Glucokinase by Glucokinase Regulatory Protein
REACT_200780Regulation of HSF1-mediated heat shock response
REACT_25216Regulation of IFNA signaling
REACT_24980Regulation of IFNG signaling
REACT_18325Regulation of insulin secretion
REACT_111225Regulation of KIT signaling
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_13528Regulation of PAK-2p34 activity by PS-GAP/RHG10
REACT_160315Regulation of PLK1 Activity at G2/M Transition
REACT_12528Regulation of pyruvate dehydrogenase (PDH) complex
REACT_21393Regulation of Rheb GTPase activity by AMPK
REACT_23787Regulation of signaling by CBL
REACT_18265Regulation of the Fanconi anemia pathway
REACT_24023Regulation of water balance by renal Aquaporins
REACT_2192Removal of DNA patch containing abasic residue
REACT_70Removal of the Flap Intermediate
REACT_7999Removal of the Flap Intermediate from the C-strand
REACT_1993Repair synthesis for gap-filling by DNA polymerase in TC-NER
REACT_378Repair synthesis of patch ~27-30 bases long by DNA polymerase
REACT_1128Resolution of AP sites via the multiple-nucleotide patch replacement pathway
REACT_150425Resolution of Sister Chromatid Cohesion
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_12435Retrograde neurotrophin signalling
REACT_118789REV-ERBA represses gene expression
REACT_11051Rho GTPase cycle
REACT_931Ribosomal scanning and start codon recognition
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_975RNA Pol II CTD phosphorylation and interaction with CE
REACT_6237RNA Pol II CTD phosphorylation and interaction with CE
REACT_2204RNA Polymerase I Chain Elongation
REACT_2232RNA Polymerase I Promoter Opening
REACT_6253RNA Polymerase II HIV Promoter Escape
REACT_22107RNA Polymerase II Pre-transcription Events
REACT_2089RNA Polymerase II Promoter Escape
REACT_833RNA Polymerase II Transcription Elongation
REACT_1851RNA Polymerase II Transcription Initiation
REACT_834RNA Polymerase II Transcription Initiation And Promoter Clearance
REACT_1655RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
REACT_19230Role of Abl in Robo-Slit signaling
REACT_22128Role of DCC in regulating apoptosis
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_160158Role of phospholipids in phagocytosis
REACT_22228Role of second messengers in netrin-1 signaling
REACT_118659RORA activates circadian gene expression
REACT_20510RSK activation
REACT_6772S6K1 signalling
REACT_6772S6K1 signalling
REACT_6754S6K1-mediated signalling
REACT_6754S6K1-mediated signalling
REACT_163679Scavenging by Class B Receptors
REACT_9003SCF(Skp2)-mediated degradation of p27/p21
REACT_9003SCF(Skp2)-mediated degradation of p27/p21
REACT_6821SCF-beta-TrCP mediated degradation of Emi1
REACT_19236Sema3A PAK dependent Axon repulsion
REACT_19279SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
REACT_19277Sema4D induced cell migration and growth-cone collapse
REACT_19266Sema4D mediated inhibition of cell attachment and migration
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_150471Separation of Sister Chromatids
REACT_115789Serine biosynthesis
REACT_1661SHC activation
REACT_21374SHC-mediated cascade
REACT_661SHC-mediated signalling
REACT_661SHC-mediated signalling
REACT_150139SHC-related events triggered by IGF1R
REACT_12579SHC1 events in EGFR signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_116005SHC1 events in ERBB4 signaling
REACT_200874Sialic acid metabolism
REACT_508Signal attenuation
REACT_23916Signal regulatory protein (SIRP) family interactions
REACT_22272Signal transduction by L1
REACT_150238Signaling by Activin
REACT_12034Signaling by BMP
REACT_115852Signaling by constitutively active EGFR
REACT_9417Signaling by EGFR
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_121398Signaling by FGFR mutants
REACT_121141Signaling by FGFR1 fusion mutants
REACT_121255Signaling by FGFR2 amplification mutants
REACT_118607Signaling by Hippo
REACT_498Signaling by Insulin receptor
REACT_169118Signaling by Leptin
REACT_111057Signaling by NODAL
REACT_16888Signaling by PDGF
REACT_19351Signaling by Robo receptor
REACT_111040Signaling by SCF-KIT
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12020Signalling to ERK5
REACT_12077Signalling to p38 via RIT and RIN
REACT_12033Signalling to RAS
REACT_12049Signalling to STAT3
REACT_200827SIRT1 negatively regulates rRNA Expression
REACT_2190SMAC binds to IAPs
REACT_1767SMAC-mediated dissociation of IAP:caspase complexes
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_20558Smooth Muscle Contraction
REACT_11066snRNP Assembly
REACT_524SOS-mediated signalling
REACT_524SOS-mediated signalling
REACT_115810Sphingolipid de novo biosynthesis
REACT_111080Spry regulation of FGF signaling
REACT_309Stabilization of p53
REACT_163734STAT6-mediated induction of chemokines
REACT_13532Stimulation of the cell death response by PAK-2p34
REACT_160189Stimuli-sensing channels
REACT_16969Striated Muscle Contraction
REACT_163942Syndecan interactions
REACT_150417Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
REACT_22423Synthesis of GDP-mannose
REACT_150352Synthesis of IP2, IP, and Ins in the cytosol
REACT_150312Synthesis of IP3 and IP4 in the cytosol
REACT_150253Synthesis of IPs in the ER lumen
REACT_150420Synthesis of Leukotrienes (LT) and Eoxins (EX)
REACT_121238Synthesis of PC
REACT_120919Synthesis of PE
REACT_121280Synthesis of PG
REACT_120756Synthesis of PIPs at the early endosome membrane
REACT_121168Synthesis of PIPs at the ER membrane
REACT_120836Synthesis of PIPs at the Golgi membrane
REACT_120918Synthesis of PIPs at the late endosome membrane
REACT_121025Synthesis of PIPs at the plasma membrane
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_6162Tat-mediated elongation of the HIV-1 transcript
REACT_6344Tat-mediated HIV elongation arrest and recovery
REACT_200777TCF dependent signaling in response to WNT
REACT_7961Telomere C-strand (Lagging Strand) Synthesis
REACT_111176Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
REACT_120850TGF-beta receptor signaling activates SMADs
REACT_120726TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_121036The activation of arylsulfatases
REACT_160156The canonical retinoid cycle in rods (twilight vision)
REACT_75927The NLRP1 inflammasome
REACT_75808The NLRP3 inflammasome
REACT_21384Thrombin signalling through proteinase activated receptors (PARs)
REACT_20647Thromboxane signalling through TP receptor
REACT_12621Tie2 Signaling
REACT_19373Tight junction interactions
REACT_1432TNF signaling
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25351TRAF6 mediated induction of TAK1 complex
REACT_24938TRAF6 mediated IRF7 activation
REACT_24969TRAF6 mediated NF-kB activation
REACT_18307Trafficking of AMPA receptors
REACT_18422Trafficking of GluR2-containing AMPA receptors
REACT_402TRAIL signaling
REACT_6233Transcription of the HIV genome
REACT_1628Transcription-coupled NER (TC-NER)
REACT_346Transcriptional activation of cell cycle inhibitor p21
REACT_200608Transcriptional activation of mitochondrial biogenesis
REACT_200812Transcriptional regulation of pluripotent stem cells
REACT_27161Transcriptional regulation of white adipocyte differentiation
REACT_1979Translation initiation complex formation
REACT_147867Translocation of GLUT4 to the plasma membrane
REACT_12596Translocation of ZAP-70 to Immunological synapse
REACT_150361TRIF-mediated programmed cell death
REACT_1190Triglyceride Biosynthesis
REACT_25064Tristetraprolin (TTP) destabilizes mRNA
REACT_11060TRKA activation by NGF
REACT_169333TRP channels
REACT_1614Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
REACT_4Ubiquitin-dependent degradation of Cyclin D1
REACT_20594Unblocking of NMDA receptor, glutamate binding and activation
REACT_12583VEGF binds to VEGFR leading to receptor dimerization
REACT_6354Viral Messenger RNA Synthesis
REACT_11070Vitamin B2 (riboflavin) metabolism
REACT_75770Voltage gated Potassium channels
REACT_163710WNT ligand biogenesis and trafficking
REACT_200668WNT mediated activation of DVL
REACT_172599WNT5A-dependent internalization of FZD4
REACT_18273XBP1(S) activates chaperone genes