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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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KEGG Pathway - Glycolysis / Gluconeogenesis

Phosphatases known in this pathway

NameSynonymsUniProt ACDephosphorylate substrates:
FBP2 (QuickGO)FBPase 2O00757D-fructose 1,6-bisphosphate
BPGM (QuickGO)BPGMP077382,3-bisphospho-D-glycerate
FBP1 (QuickGO)FBPase 1P09467D-fructose 1,6-bisphosphate
PGAM2 (QuickGO)PGAM-MP152592,3-bisphospho-D-glycerate
PGAM1 (QuickGO)PGAM-BP186692,3-bisphospho-D-glycerate
G6PC (QuickGO)G6PaseP35575alpha-D-glucose 6-phosphate beta-D-glucose 6-phosphate
PGAM4 (QuickGO)PGAM-4Q8N0Y72,3-bisphospho-D-glycerate
G6PC2 (QuickGO)G6Pase2Q9NQR9alpha-D-glucose 6-phosphate beta-D-glucose 6-phosphate

Substrates known in this pathway

NameSynonymsUniProt ACDephosphorylated by phosphatases:
PDHA1Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)P08559PDP1 PDP2
PDHA2Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II)P29803PDP1 PDP2
GlucokinaseGlucokinase (EC 2.7.1.2) (Hexokinase type IV) (HK IV) (Hexokinase-4) (HK4) (Hexokinase-D)P35557YVH1
2,3-bisphospho-D-glycerate2,3-bisphospho-D-glycerate; 2,3-Bisphospho-D-glycerate; 2,3-bisphospho-D-glyceric acid; 2,3-disphospho-D-glycerate; 2,3-Disphospho-D-glycerate; D-Greenwald ester; DPG; 2,3-BPGN/ABPGM MINPP1 PGAM-4 PGAM-B PGAM-M
alpha-D-glucose 1-phosphate1-O-phosphono-alpha-D-glucopyranose; alpha-D-Glucose 1-phosphate; ALPHA-D-GLUCOSE-1-PHOSPHATE; alpha-D-Glucose-1-phosphateN/AIMP 1 IMP 2
alpha-D-glucose 6-phosphate6-O-phosphono-alpha-D-glucopyranose; alpha-D-Glucose 6-phosphate; ALPHA-D-GLUCOSE-6-PHOSPHATEN/AG6Pase G6Pase2 G6Pase3 IMP 1
beta-D-glucose 6-phosphate6-O-phosphono-beta-D-glucopyranose; 6-O-phosphono-beta-D-glucopyranose; beta-D-Glucose 6-phosphate; BETA-D-GLUCOSE-6-PHOSPHATEN/AG6Pase G6Pase2 G6Pase3 IMP 1

Sorry, no phosphatase/substrate known in this pathway here!

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