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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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KEGG Pathway - Purine metabolism

Phosphatases known in this pathway

NameSynonymsUniProt ACDephosphorylate substrates:
NT5E (QuickGO)CD73P215895'-AMP 5'-GMP 5'-IMP
NT5C2 (QuickGO)Cytosolic 5'-nucleotidase 2P499025'-dAMP 5'-dGMP 5'-dIMP 5'-dTMP 5'-dUMP 5'-GMP 5'-IMP 5'-UMP
NT5C (QuickGO)Deoxy-5'-nucleotidase 1Q8TCD52'-UMP 3'-dUMP 3'-UMP 5'-dAMP 5'-dGMP 5'-dIMP 5'-dTMP 5'-dUMP 5'-GMP 5'-IMP 5'-UMP
NT5C1B (QuickGO)Cytosolic 5'-nucleotidase 1BQ96P26N/A
NT5C1A (QuickGO)Cytosolic 5'-nucleotidase 1AQ9BXI35'-AMP 5'-CMP 5'-dAMP 5'-dCMP 5'-dGMP 5'-dIMP 5'-dUMP 5'-GMP 5'-IMP 5'-TMP 5'-UMP
NT5C3 (QuickGO)Cytosolic 5'-nucleotidase 3Q9H0P05'-CMP 5'-dCMP 5'-dTMP 5'-dUMP 5'-UMP
NT5M (QuickGO)Deoxy-5'-nucleotidase 2Q9NPB12'-UMP 3'-dTMP 3'-UMP 5'-dTMP 5'-dUMP 5'-UMP

Substrates known in this pathway

NameSynonymsUniProt ACDephosphorylated by phosphatases:
POLR2ADNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)P24928CTDSP-like 2 Eya1 Eya3 FCP1 RPAP2 SCP1 SCP2 SSU72 UBLCP1
POLD3DNA polymerase delta subunit 3 (DNA polymerase delta subunit p66)Q15054PP1alpha PP1beta PP1gamma
N/AN/A
5'-AMP5'-Adenosine monophosphate; 5'-Adenylic acid; 5'-AMP; 5'-O-phosphonoadenosine; adenosine 5'-(dihydrogen phosphate); Adenosine 5'-monophosphate; Adenosine 5'-phosphate; ADENOSINE MONOPHOSPHATE; adenosine phosphate; adenosine-5'P; Adenylate; Adenylic acid; Ado5'P; AMP; PAdoN/AACPP AP-TNAP CD73 Cytosolic 5'-nucleotidase 1A
5'-dAMP2'-dAMP; 2'-deoxy-5'-adenosine monophosphate; 2'-deoxy-AMP; 2'-deoxyadenosine 5'-(dihydrogen phosphate); 2'-deoxyadenosine 5'-monophosphate; 2'-Deoxyadenosine 5'-monophosphate; 2'-Deoxyadenosine 5'-phosphate; 2'-deoxyadenosine monophosphate; 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE; 2'-deoxyadenylic acid; dAMP; deoxy-5'-adenylic acid; deoxy-AMP; deoxyadenosine 5'-monophosphate; deoxyadenosine 5'-phosphate; Deoxyadenosine monophosphate; Deoxyadenylic acid; 5'-dAMPN/ACytosolic 5'-nucleotidase 1A Cytosolic 5'-nucleotidase 2 Deoxy-5'-nucleotidase 1
5'-dGMP2'-deoxyguanosine 5'-monophosphate; 2'-Deoxyguanosine 5'-monophosphate; 2'-Deoxyguanosine 5'-phosphate; Deoxyguanosine monophosphate; Deoxyguanylic acid; dGMP; 5'-dGMPN/ACytosolic 5'-nucleotidase 1A Cytosolic 5'-nucleotidase 2 Deoxy-5'-nucleotidase 1
5'-dIMP2'-Deoxyinosine 5'-monophosphate; 2'-Deoxyinosine 5'-phosphate; 9-(2-deoxy-5-O-phosphono--D-erythro-pentofuranosyl)-9H-purin-6-ol; Deoxyinosine monophosphate; dIMP; Hypoxanthine deoxyriboside; 5'-dIMPN/ACytosolic 5'-nucleotidase 1A Cytosolic 5'-nucleotidase 2 Deoxy-5'-nucleotidase 1
5'-GMP5'-GMP; 5'-guanylic acid; GMP; Guanosine 5'-monophosphate; Guanosine 5'-phosphate; Guanosine monophosphate; Guanylic acidN/ACD73 Cytosolic 5'-nucleotidase 1A Cytosolic 5'-nucleotidase 2 Deoxy-5'-nucleotidase 1
5'-IMP2'-inosine-5'-monophosphate; 5'-IMP; 5'-Inosinate; 5'-Inosine monophosphate; 5'-Inosinic acid; IMP; Inosine 5'-monophosphate; Inosine 5'-phosphate; Inosine monophosphate; inosinic acid; Inosinic acidN/ACD73 Cytosolic 5'-nucleotidase 1A Cytosolic 5'-nucleotidase 2 Deoxy-5'-nucleotidase 1
adenosine 3',5'-bisphosphate3'-phosphoadenylate; 3'-Phosphoadenylate; adenosine 3',5'-bisphosphate; Adenosine 3',5'-bisphosphate; PAP; Phosphoadenosine phosphate; 3'-phosphoadenosine 5'-phosphateN/ABPNT1
D-ribose 5-phosphate5-O-phosphono-D-ribose; D-Ribose 5-phosphate; Ribose 5-phosphateN/AMDP-1

Sorry, no phosphatase/substrate known in this pathway here!

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