spacer
Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
--------------------------------
213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
--------------------------------
last update: 18 Feb, 2016

spacer

Protein substrates of human phosphatases

AAA ATPase family
Abd-B homeobox family
Aconitase/IPM isomerase family
Actin-binding proteins ADF family
Adenosylhomocysteinase family
Aldolase class II family, Adducin subfamily
Alpha-actinin family
Alpha-casein family
Anion exchanger (TC 2.A.31) family
BCKDHA family
Bcl-2 family
Beta-casein family
Beta-catenin family
BZIP family
BZIP family, Jun subfamily
Calreticulin family
Calycin superfamily, Fatty-acid binding protein (FABP) family
CAMP-dependent kinase regulatory chain family
CAS family
Caveolin family
CD36 family
CD3Z/FCER1G family
CDC37 family
CDI family
Centrin family
Coilin family
CRK family
CUT homeobox family
Cyclin-dependent kinase 5 activator family
DEAD box helicase family, DDX20 subfamily
DHOase family
DOK family, Type A subfamily
Dwarfin/SMAD family
Dynamin family
EIF-2-alpha family
ELL/occludin family
Ena/VASP family
ETS family
Filamin family
GAB family
Glycosyltransferase 3 family
GOLGA2 family
G-protein coupled receptor 1 family, Opsin subfamily
G-protein coupled receptor 3 family
G-protein coupled receptor Fz/Smo family
Group II decarboxylase family
GTP-binding elongation factor family, EF-G/EF-2 subfamily
Hexokinase family
Histone deacetylase family, HD type 1 subfamily
Histone deacetylase family, HD type 2 subfamily
Histone H2A family
Histone H2B family
Histone H3 family
Histone H4 family
Histone-lysine methyltransferase family, PR/SET subfamily
Ikaros C2H2-type zinc-finger protein family
Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
INCENP family
Integrin beta chain family
Intermediate filament family
Kinesin-like protein family
Lipin family
Low molecular weight phosphotyrosine protein phosphatase family
MAGUK family
MDM2/MDM4 family
MPI phosphatase family
Myelin basic protein family
Myelin P0 protein family
N-CoR nuclear receptor corepressors family
NF-kappa-B inhibitor family
NifU family
NOS family
Nuclear hormone receptor family, NR3 subfamily
NudE family
P53 family
PACS family
PAR3 family
Paxillin family
PDCD10 family
Peptidase C14A family
Phosphatase 2A regulatory subunit B56 family
PI3/PI4-kinase family
PI3/PI4-kinase family, ATM subfamily
PI3K p85 subunit family
Potassium channel family, B (Shab) (TC 1.A.1.2) subfamily, Kv2.1/KCNB1 sub-subfamily
Potassium channel KCNN family, KCa3.1/KCNN4 subfamily
PPP phosphatase family, PP-1 subfamily
Protein kinase superfamily, AGC Ser/Thr protein kinase family, cAMP subfamily
Protein kinase superfamily, AGC Ser/Thr protein kinase family, cGMP subfamily
Protein kinase superfamily, AGC Ser/Thr protein kinase family, DMPK subfamily
Protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
Protein kinase superfamily, AGC Ser/Thr protein kinase family, RAC subfamily
Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
Protein kinase superfamily, CAMK Ser/Thr protein kinase family
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CHK2 subfamily
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, PKD subfamily
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, GSK-3 subfamily
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
Protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily
Protein kinase superfamily, Ser/Thr protein kinase family, CDC5/Polo subfamily
Protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily
Protein kinase superfamily, Ser/Thr protein kinase family, I-kappa-B kinase subfamily
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Protein kinase superfamily, TKL Ser/Thr protein kinase family
Protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily
Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Protein kinase superfamily, Tyr protein kinase family
Protein kinase superfamily, Tyr protein kinase family, ABL subfamily
Protein kinase superfamily, Tyr protein kinase family, ABL subfamily.
Protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily
Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
Protein kinase superfamily, Tyr protein kinase family, FAK subfamily
Protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily
Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Protein kinase superfamily, Tyr protein kinase family, JAK subfamily
Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
Protein kinase superfamily, Tyr protein kinase family, SYK/ZAP-70 subfamily
Protein kinase superfamily, Tyr protein kinase family, TEC subfamily
Protein kinase superfamily, Tyr protein kinase family, Tie subfamily
Protein phosphatase inhibitor 1 family
Protein-tyrosine phosphatase family
Protein-tyrosine phosphatase family, Non-receptor class 1 subfamily
Protein-tyrosine phosphatase family, Non-receptor class 2 subfamily
Protein-tyrosine phosphatase family, Non-receptor class subfamily
Protein-tyrosine phosphatase family, Receptor class 2A subfamily
Protein-tyrosine phosphatase family, Receptor class 4 subfamily
RCAN family
Retinoblastoma protein (RB) family
RNA polymerase beta' chain family
Ryanodine receptor (TC 1.A.3.1) family, RYR1 subfamily
Selectin/LECAM family
Sirtuin family
SKAP family
Small heat shock protein (HSP20) family
SMN family
Sodium:bile acid symporter family
Sprouty family
STAM family
Stathmin family
Succinate/malate CoA ligase beta subunit family; Succinate/malate CoA ligase alpha subunit family
Sulfatase family
Synuclein family
TNF receptor-associated factor family, A subfamily
Transcription factor STAT family
Transient receptor (TC 1.A.4) family, TrpV subfamily, TRPV6 sub-subfamily
Troponin I family
Troponin T family
Type I cytokine receptor family, Type 1 subfamily
Type I cytokine receptor family, Type 2 subfamily
Uracil-DNA glycosylase family
WD repeat CDC20/Fizzy family
WD repeat coronin family
WD repeat G protein beta family
XPO2/CSE1 family
Zyxin/ajuba family
Other


spacer
spacer