Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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NT5C
Gene Name  | NT5C (QuickGO) | (A quick tutorial to explore the interctive visulaization) |
| Synonyms | NT5C, DNT1, UMPH2 | |
| Protein Name | NT5C |
|
| Alternative Name(s) |
5'(3')-deoxyribonucleotidase, cytosolic type;3.1.3.-;Cytosolic 5',3'-pyrimidine nucleotidase;Deoxy-5'-nucleotidase 1;dNT-1; | |
| EntrezGene ID | 30833 (Comparitive Toxicogenomics) | |
| UniProt AC (Human) | Q8TCD5 (protein sequence) | |
| Enzyme Class | N/A | |
| Molecular Weight | 23383 Dalton | |
| Protein Length | 201 amino acids (AA) | |
| Genome Browsers | NCBI | ENSG00000125458 (Ensembl) | UCSC | |
| Crosslinking annotations | Query our ID-mapping table | |
| Orthologues | Quest For Orthologues (QFO) | GeneTree | |
| Classification | Superfamily: HAD | Historic class: 5'(3')-deoxyribonucleotidase | CATH ID: 3.40.50.1000 | SCOP Fold: HAD | |
| Phosphatase activity | active | Catalytic signature motif: unknown | |
| Phosphorylation Network | Visualize | |
| Domain organization, Expression, Diseases | (show / hide) |
| Protein Domain | InterPro | Pfam | SMART | 3D Structure | PDB | DrugPort | ModBase | SwissModel |
| Polypeptide organization (Pfam) | No Pfam domain found | ||
| Catalytic Site | Mechanism and Catalytic Site Atlas | ||
| Gene Expression | Gene Expression Atlas | Diseases | OMIM | DisGeNet | ClinVar |
| Protein-protein interactions | STRING | IntAct | MINT | BioGRID | ||
| Phosphosites | Phospho.ELM | PhosphoSitePlus | ||
| Localization, Function, Catalytic activity and Sequence | (show / hide) |
| Localization (UniProt annotation) | |||
| Cytoplasm | |||
| Function (UniProt annotation) | |||
| Dephosphorylates the 5' and 2'(3')-phosphates ofdeoxyribonucleotides, with a preference for dUMP and dTMP,intermediate activity towards dGMP, and low activity towards dCMPand dAMP | |||
| Catalytic Activity (UniProt annotation) | |||
| NA | |||
| Protein Sequence | |||
| MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADKVASVYEAPGFFLDLEPIPGA LDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHLGPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEH ILFTCCHNRHLVLPPTRRRLLSWSDNWREILDSKRGAAQRE |
| Motif information from Eukaryotic Linear Motif atlas (ELM) | (show / hide) |
ELM Motif | Motif Instance | Description | Motif Regex |
| NA | NA | NA | NA |
| Gene Ontology (P: Process; F: Function and C: Component terms) | (show / hide) | |
| GO:0005634 | C:nucleus |
| GO:0005737 | C:cytoplasm |
| GO:0005829 | C:cytosol |
| GO:0006195 | P:purine nucleotide catabolic process |
| GO:0008252 | F:nucleotidase activity |
| GO:0008253 | F:5'-nucleotidase activity |
| GO:0009223 | P:pyrimidine deoxyribonucleotide catabolic process |
| GO:0016311 | P:dephosphorylation |
| GO:0019103 | F:pyrimidine nucleotide binding |
| GO:0046135 | P:pyrimidine nucleoside catabolic process |
| GO:0046872 | F:metal ion binding |
| GO:0070062 | C:extracellular exosome |
