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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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KEGG Pathway - Pyrimidine metabolism

Phosphatases known in this pathway

NameSynonymsUniProt ACDephosphorylate substrates:
NT5E (QuickGO)CD73P215895'-AMP 5'-GMP 5'-IMP
NT5C2 (QuickGO)Cytosolic 5'-nucleotidase 2P499025'-dAMP 5'-dGMP 5'-dIMP 5'-dTMP 5'-dUMP 5'-GMP 5'-IMP 5'-UMP
NT5C (QuickGO)Deoxy-5'-nucleotidase 1Q8TCD52'-UMP 3'-dUMP 3'-UMP 5'-dAMP 5'-dGMP 5'-dIMP 5'-dTMP 5'-dUMP 5'-GMP 5'-IMP 5'-UMP
NT5C1B (QuickGO)Cytosolic 5'-nucleotidase 1BQ96P26N/A
NT5C1A (QuickGO)Cytosolic 5'-nucleotidase 1AQ9BXI35'-AMP 5'-CMP 5'-dAMP 5'-dCMP 5'-dGMP 5'-dIMP 5'-dUMP 5'-GMP 5'-IMP 5'-TMP 5'-UMP
NT5C3 (QuickGO)Cytosolic 5'-nucleotidase 3Q9H0P05'-CMP 5'-dCMP 5'-dTMP 5'-dUMP 5'-UMP
NT5M (QuickGO)Deoxy-5'-nucleotidase 2Q9NPB12'-UMP 3'-dTMP 3'-UMP 5'-dTMP 5'-dUMP 5'-UMP

Substrates known in this pathway

NameSynonymsUniProt ACDephosphorylated by phosphatases:
POLR2ADNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)P24928CTDSP-like 2 Eya1 Eya3 FCP1 RPAP2 SCP1 SCP2 SSU72 UBLCP1
CADCAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]P27708PP1alpha PP1beta PP1gamma PP2Aalpha PP2Abeta
POLD3DNA polymerase delta subunit 3 (DNA polymerase delta subunit p66)Q15054PP1alpha PP1beta PP1gamma
3'-UMP3'-UMP; Uridine 3'-monophosphate; Uridine 3'-phosphate; 3'-uridylateN/ADeoxy-5'-nucleotidase 1 Deoxy-5'-nucleotidase 2
5'-CMPCMP; cytidine 5'-monophosphate; Cytidine-5'-monophosphate; cytidylate; Cytidylic acid; 5'-CMPN/ACytosolic 5'-nucleotidase 1A Cytosolic 5'-nucleotidase 3
5'-dCMP2'-Deoxycytidine 5'-monophosphate; 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE; 2'-deoxycytosine 5'-monophosphate; dCMP; Deoxycytidine monophosphate; Deoxycytidylate; Deoxycytidylic acid; 5'-dCMPN/ACytosolic 5'-nucleotidase 1A Cytosolic 5'-nucleotidase 3
5'-dTMP5'-Thymidylic acid; 5'-TMP; 5-methyl-dUMP; deoxyribosylthymine monophosphate; thymidine 5'-(dihydrogen phosphate); Thymidine 5'-phosphate; thymidine 5'-phosphoric acid; Thymidine monophosphate; thymidine-5'-monophosphoric acid; THYMIDINE-5'-PHOSPHATE; Thymidylate; Thymidylic acid; 5'-dTMP; 2'-deoxythymidine 5'-monophosphate; dTMPN/ACytosolic 5'-nucleotidase 2 Cytosolic 5'-nucleotidase 3 Deoxy-5'-nucleotidase 1 Deoxy-5'-nucleotidase 2
5'-dUMP2'-deoxyuridine 5'-monophosphate; 2'-Deoxyuridine 5'-phosphate; Deoxyuridine 5'-phosphate; Deoxyuridine monophosphate; deoxyuridylate; Deoxyuridylic acid; dUMP; 5'-dUMP; deoxyuridylateN/ACytosolic 5'-nucleotidase 1A Cytosolic 5'-nucleotidase 2 Cytosolic 5'-nucleotidase 3 Deoxy-5'-nucleotidase 1 Deoxy-5'-nucleotidase 2
5'-UMP5'-UMP; 5'Uridylic acid; pU; UMP; uridine 5'-(dihydrogen phosphate); Uridine 5'-monophosphate; uridine 5'-phosphate; uridine 5'-phosphoric acid; Uridine monophosphate; URIDINE-5'-MONOPHOSPHATE; uridylate; Uridylic acid; 5'-uridylateN/ACytosolic 5'-nucleotidase 1A Cytosolic 5'-nucleotidase 2 Cytosolic 5'-nucleotidase 3 Deoxy-5'-nucleotidase 1 Deoxy-5'-nucleotidase 2

Sorry, no phosphatase/substrate known in this pathway here!

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