Top CAD
Localization (UniProt annotation) Cytoplasm Nucleus Note=Cytosolic andunphosphorylated in resting cells, translocates to the nucleus inresponse to EGF stimulation, nuclear import promotes optimal cellgrowth Function (UniProt annotation) This protein is a fusionprotein encoding fourenzymatic activities of the pyrimidine pathway (GATase, CPSase,ATCase and DHOase) Catalytic Activity (UniProt annotation) 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2ADP + phosphate + L-glutamate + carbamoyl phosphate Carbamoyl phosphate + L-aspartate = phosphate+ N-carbamoyl-L-aspartate (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate Protein Sequence MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYGIPPDEMDEFGLCKWFESSG
IHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVP
EVSIKTPRVFNTGGAPRILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVL
SEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVETDSLPADWAPLFTNANDGSN
EGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILG
SGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQT
ALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFAL
GGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTL
NDREYQLLRQTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRN
SVTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMVDENCVGFDHTVKPVSDM
ELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAV
LSTELAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQ
QLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPE
AIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKE
HPVVISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFN
LQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKVPQFSFSRLAGADVVLGV
EMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVT
AVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEAL
GQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDAPALALAQ
KLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVL
MVAQLTQRSVHICHVARKEEILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVI
DCFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPPQEDTYVEVDLEHEWTI
PSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRG
IPGLPDGRFHLPPRIHRASDPGLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHS
LVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSS
VQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGD
LKHGRTVHSLACLLTQYRVSLRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEA
CFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATVLGRF
ELM Motif Motif Instance Description Motif Regex NA NA NA NA
CAD is dephosphorylated by following phosphatases:
Phosphatase Gene Name Phosphatase UniProt_AC DephosphoSite and sequence (+/-5) in CAD (P27708) Bioassay Type PubMed ID View in Europe PMC Reliability of the interaction PPP1CA P62136 Ser-1406_GGRRLsSFVTK, , Ser-1859_RIHRAsDPGLP , In vitro 4092695 , Europe PMC PPP1CB P62140 Ser-1406_GGRRLsSFVTK, , Ser-1859_RIHRAsDPGLP , In vitro 4092695 , Europe PMC PPP1CC P36873 Ser-1406_GGRRLsSFVTK, , Ser-1859_RIHRAsDPGLP , In vitro 4092695 , Europe PMC PPP2CA P67775 Ser-1406_GGRRLsSFVTK, , Ser-1859_RIHRAsDPGLP , In vitro 4092695 , Europe PMC PPP2CB P62714 Ser-1406_GGRRLsSFVTK, , Ser-1859_RIHRAsDPGLP , In vitro 4092695 , Europe PMC
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-500753 Pyrimidine biosynthesis. The pyrimidine orotate (orotic acid) is synthesized in a sequence of four reactions, deriving its atoms from glutamine, bicarbonate, and aspartate. A single multifunctional cytosolic enzyme catalyzes the first three of these reactions, while the last one is catalyzed by an enzyme associated with the inner mitochondrial membrane. In two further reactions, catalyzed by a bifunctional cytosolic enzyme, orotate reacts with 1-phosphoribosyl 5-pyrophosphate (PRPP) to yield orotidine 5'-monophosphate, which is decarboxylated to yield uridine 5'-monophosphate (UMP). While several individual reactions in this pathway are reversible, other irreversible reactions drive the pathway in the direction of UMP biosynthesis in the normal cell. All reactions are thus annotated here only in the forward direction.This pathway has been most extensively analyzed at the genetic and biochemical level in hamster cell lines. All three enzymes have also been purified from human sources, however, and the key features of these reactions have been confirmed from studies of this human material (Jones 1980; Webster et al. 2001).
All other pyrimidines are synthesized from UMP. The reactions annotaed here, catalyzed by dCMP deaminase and dUTP diphosphatase yield dUMP, which in turn is converted to TMP by thymidylate synthase
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ACTB Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ACTG1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ACTR1A Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID AHI1 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct ATP1A1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID BRCA1 Affinity Capture-MS physical 26831064 , (Europe PMC )NA BioGRID CBL Affinity Capture-MS physical 19380743 , (Europe PMC )NA BioGRID CCDC8 Affinity Capture-MS physical 24711643 , (Europe PMC )NA BioGRID CCT3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CCT4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CCT6A Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CCT8 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CDK2 Affinity Capture-MS physical 21319273 , (Europe PMC )NA BioGRID CFTR Affinity Capture-MS physical 26618866 , (Europe PMC )NA BioGRID CLTC Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID COPB1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CUL3 Affinity Capture-MS physical 21145461 , (Europe PMC )NA BioGRID CUL7 Affinity Capture-MS physical 24711643 , (Europe PMC )NA BioGRID CYLD Affinity Capture-MS physical 27591049 , (Europe PMC )NA BioGRID DARS Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID DDX3X Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID DERL1 Affinity Capture-MS physical 28137758 , (Europe PMC )NA BioGRID DNAJA1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID DNAJA2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID DNAJA3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID DNAJA4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID DNAJC7 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct EEF1A1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID EIF2B1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID EIF2S1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID EPRS Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ERG Affinity Capture-MS physical 21575865 , (Europe PMC )NA BioGRID FASN Affinity Capture-Western physical 28775317 , (Europe PMC )NA BioGRID FBXO25 Affinity Capture-MS physical 20473970 , (Europe PMC )NA BioGRID FBXO6 Affinity Capture-MS physical 22268729 , (Europe PMC )NA BioGRID GFPT1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID GRB2 Affinity Capture-MS, tandem affinity purification association, physical 19380743 , (Europe PMC )0.35 BioGRID, IntAct HDAC11 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 23752268 , (Europe PMC )0.35 BioGRID, IntAct HDAC5 Affinity Capture-MS physical 21081666 , (Europe PMC )NA BioGRID HDAC6 Affinity Capture-MS physical 23703321 , (Europe PMC )NA BioGRID HSPA5 Affinity Capture-MS physical 26496610 , (Europe PMC )NA BioGRID HSPA8 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HTRA2 Protein-peptide physical 17266347 , (Europe PMC )NA BioGRID IARS Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID IDH3A Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ILK Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification association, physical 23455922 , 25852190 , 26496610 , (Europe PMC )0.64 BioGRID, IntAct IPO4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ITGA4 Affinity Capture-MS physical 22623428 , (Europe PMC )NA BioGRID KEAP1 Affinity Capture-MS physical 27621311 , (Europe PMC )NA BioGRID LGALS3BP Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct LGR4 Affinity Capture-MS physical 24639526 , (Europe PMC )NA BioGRID MAD2L1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct MCM2 Affinity Capture-MS physical 25963833 , (Europe PMC )NA BioGRID MCM7 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID MEX3C Affinity Capture-MS, pull down association, physical 22863774 , 26471122 , (Europe PMC )0.35 BioGRID, IntAct, MINT MKS1 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct MTMR11 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID NCOA2 Affinity Capture-MS physical 16051665 , (Europe PMC )NA BioGRID NEDD4 Reconstituted Complex physical 16055720 , (Europe PMC )NA BioGRID NFATC1 Affinity Capture-MS physical 27637333 , (Europe PMC )NA BioGRID NFATC2 Affinity Capture-MS physical 27637333 , (Europe PMC )NA BioGRID NOS2 Affinity Capture-MS physical 23438482 , (Europe PMC )NA BioGRID NTRK1 Affinity Capture-MS physical 25921289 , (Europe PMC )NA BioGRID OBSL1 Affinity Capture-MS physical 24711643 , (Europe PMC )NA BioGRID OTUB1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26752685 , (Europe PMC )0.35 BioGRID, IntAct PC Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID POC1B Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct POU5F1 Affinity Capture-MS physical 26687479 , (Europe PMC )NA BioGRID PSMC2 Co-fractionation physical 22939629 , 26344197 , (Europe PMC )NA BioGRID PSMC3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PSMC4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PSMC5 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PSMC6 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PSMD1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PSMD12 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PSMD2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PSMD4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID RAD21 Affinity Capture-Western physical 22145905 , (Europe PMC )NA BioGRID RC3H1 Affinity Capture-MS physical 26170170 , (Europe PMC )NA BioGRID RPS3 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID RPS6KB2 Affinity Capture-MS physical 25324306 , (Europe PMC )NA BioGRID RUVBL1 Co-fractionation physical 22939629 , 26344197 , (Europe PMC )NA BioGRID RUVBL2 Co-fractionation physical 22939629 , 26344197 , (Europe PMC )NA BioGRID SARS Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID SEC16A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct SHC1 Affinity Capture-MS, tandem affinity purification association, physical 19380743 , (Europe PMC )0.35 BioGRID, IntAct SIRT7 Affinity Capture-MS physical 22586326 , (Europe PMC )NA BioGRID SKI Affinity Capture-MS physical 25670202 , (Europe PMC )NA BioGRID SLC25A3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID SMAD2 Affinity Capture-MS, tandem affinity purification physical, physical association 18729074 , (Europe PMC )0.40 BioGRID, IntAct SMARCA4 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SMARCC2 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SPRTN Affinity Capture-MS physical 23254330 , (Europe PMC )NA BioGRID STAU1 Affinity Capture-MS physical 23125841 , (Europe PMC )NA BioGRID SUMO2 Reconstituted Complex physical 19394292 , (Europe PMC )NA BioGRID TES Affinity Capture-MS physical 28378594 , (Europe PMC )NA BioGRID TP53 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TP63 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 20085233 , (Europe PMC )0.35 BioGRID, IntAct TRIM29 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct TUBA1C Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct TUBA4A Co-fractionation physical 22939629 , 26344197 , (Europe PMC )NA BioGRID TUBB2A Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID TUBB4B Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID TUBG1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID UBR5 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID UQCRC2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID VARS Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID VHL Affinity Capture-MS, Affinity Capture-Western physical 28775317 , (Europe PMC )NA BioGRID WWOX Affinity Capture-MS physical 24550385 , (Europe PMC )NA BioGRID XPO1 Co-fractionation physical 22939629 , 26344197 , (Europe PMC )NA BioGRID YAP1 Affinity Capture-MS physical 25796446 , (Europe PMC )NA BioGRID YME1L1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ZNF746 Affinity Capture-MS physical 25315684 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source CAD cosedimentation in solution, x-ray crystallography direct interaction 24332717 , (Europe PMC )0.56 IntAct DNAJC7 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct DUSP16 pull down association 28330616 , (Europe PMC )0.35 IntAct ESR1 tandem affinity purification association 25604459 , (Europe PMC )0.35 IntAct ESR2 tandem affinity purification association 25604459 , (Europe PMC )0.35 IntAct GABARAP anti tag coimmunoprecipitation association 20562859 , (Europe PMC )0.35 IntAct GABARAPL1 anti tag coimmunoprecipitation association 20562859 , (Europe PMC )0.35 IntAct GABARAPL2 anti tag coimmunoprecipitation association 20562859 , (Europe PMC )0.35 IntAct GRB2 Affinity Capture-MS, tandem affinity purification association, physical 19380743 , (Europe PMC )0.35 BioGRID, IntAct HDAC11 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 23752268 , (Europe PMC )0.35 BioGRID, IntAct HSCB anti bait coimmunoprecipitation association 28380382 , (Europe PMC )0.35 IntAct HSPA5 anti tag coimmunoprecipitation association 26496610 , (Europe PMC )0.35 IntAct HTR7 tandem affinity purification association 19486527 , (Europe PMC )0.35 IntAct IKBKG tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct ILK Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification association, physical 23455922 , 25852190 , 26496610 , (Europe PMC )0.64 BioGRID, IntAct JUN anti bait coimmunoprecipitation association 25609649 , (Europe PMC )0.35 IntAct, MINT LGALS3BP Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct LRFN4 anti tag coimmunoprecipitation association 22677168 , (Europe PMC )0.35 IntAct, MINT MAD2L1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct MAP1LC3A anti tag coimmunoprecipitation association 20562859 , (Europe PMC )0.35 IntAct MAP1LC3B anti tag coimmunoprecipitation association 20562859 , (Europe PMC )0.35 IntAct MAP3K1 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct MAP3K14 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct MAP3K3 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct MAP3K7 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct MAPK6 anti tag coimmunoprecipitation association 26972000 , (Europe PMC )0.35 IntAct MEX3C Affinity Capture-MS, pull down association, physical 22863774 , 26471122 , (Europe PMC )0.35 BioGRID, IntAct, MINT MKS1 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct NFKB2 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct NFKBIE tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct OTUB1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26752685 , (Europe PMC )0.35 BioGRID, IntAct POC1B Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct PPEF1 pull down association 28330616 , (Europe PMC )0.35 IntAct PPP2R2B anti tag coimmunoprecipitation association 19156129 , (Europe PMC )0.35 IntAct PPP5C proximity-dependent biotin identification, pull down association 28330616 , (Europe PMC )0.46 IntAct PTBP3 anti bait coimmunoprecipitation association 22575643 , (Europe PMC )0.35 IntAct, MINT PTPN23 pull down association 28330616 , (Europe PMC )0.35 IntAct RELA tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct RELB tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct RIPK1 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct RIPK3 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct RIPK4 anti tag coimmunoprecipitation association 26972000 , (Europe PMC )0.35 IntAct RPS9 anti bait coimmunoprecipitation association 17461779 , (Europe PMC )0.35 IntAct SEC16A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct SHC1 Affinity Capture-MS, tandem affinity purification association, physical 19380743 , (Europe PMC )0.35 BioGRID, IntAct SMAD2 Affinity Capture-MS, tandem affinity purification physical, physical association 18729074 , (Europe PMC )0.40 BioGRID, IntAct TAB2 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct TNFRSF1A tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct TNFRSF1B tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct TP63 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 20085233 , (Europe PMC )0.35 BioGRID, IntAct TRADD tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct TRAF2 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct TRIM29 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct TUBA1A pull down association 27291054 , 29568061 , (Europe PMC )0.53 IntAct TUBA1C Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct TUBB3 pull down association 27291054 , (Europe PMC )0.35 IntAct VCAM1 cross-linking study association 22623428 , (Europe PMC )0.35 IntAct YWHAZ pull down physical association 15161933 , (Europe PMC )0.40 IntAct, MINT
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source LRFN4 anti tag coimmunoprecipitation association 22677168 , (Europe PMC )0.35 IntAct, MINT MEX3C Affinity Capture-MS, pull down association, physical 22863774 , 26471122 , (Europe PMC )0.35 BioGRID, IntAct, MINT PTBP3 anti bait coimmunoprecipitation association 22575643 , (Europe PMC )0.35 IntAct, MINT YWHAZ pull down physical association 15161933 , (Europe PMC )0.40 IntAct, MINT
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ACTB Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ACTG1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ACTR1A Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID AHI1 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct ATP1A1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID BRCA1 Affinity Capture-MS physical 26831064 , (Europe PMC )NA BioGRID CAD cosedimentation in solution, x-ray crystallography direct interaction 24332717 , (Europe PMC )0.56 IntAct CBL Affinity Capture-MS physical 19380743 , (Europe PMC )NA BioGRID CCDC8 Affinity Capture-MS physical 24711643 , (Europe PMC )NA BioGRID CCT3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CCT4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CCT6A Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CCT8 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CDK2 Affinity Capture-MS physical 21319273 , (Europe PMC )NA BioGRID CFTR Affinity Capture-MS physical 26618866 , (Europe PMC )NA BioGRID CLTC Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID COPB1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CUL3 Affinity Capture-MS physical 21145461 , (Europe PMC )NA BioGRID CUL7 Affinity Capture-MS physical 24711643 , (Europe PMC )NA BioGRID CYLD Affinity Capture-MS physical 27591049 , (Europe PMC )NA BioGRID DARS Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID DDX3X Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID DERL1 Affinity Capture-MS physical 28137758 , (Europe PMC )NA BioGRID DNAJA1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID DNAJA2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID DNAJA3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID DNAJA4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID DNAJC7 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct DUSP16 pull down association 28330616 , (Europe PMC )0.35 IntAct EEF1A1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID EIF2B1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID EIF2S1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID EPRS Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ERG Affinity Capture-MS physical 21575865 , (Europe PMC )NA BioGRID ESR1 tandem affinity purification association 25604459 , (Europe PMC )0.35 IntAct ESR2 tandem affinity purification association 25604459 , (Europe PMC )0.35 IntAct FASN Affinity Capture-Western physical 28775317 , (Europe PMC )NA BioGRID FBXO25 Affinity Capture-MS physical 20473970 , (Europe PMC )NA BioGRID FBXO6 Affinity Capture-MS physical 22268729 , (Europe PMC )NA BioGRID GABARAP anti tag coimmunoprecipitation association 20562859 , (Europe PMC )0.35 IntAct GABARAPL1 anti tag coimmunoprecipitation association 20562859 , (Europe PMC )0.35 IntAct GABARAPL2 anti tag coimmunoprecipitation association 20562859 , (Europe PMC )0.35 IntAct GFPT1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID GRB2 Affinity Capture-MS, tandem affinity purification association, physical 19380743 , (Europe PMC )0.35 BioGRID, IntAct HDAC11 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 23752268 , (Europe PMC )0.35 BioGRID, IntAct HDAC5 Affinity Capture-MS physical 21081666 , (Europe PMC )NA BioGRID HDAC6 Affinity Capture-MS physical 23703321 , (Europe PMC )NA BioGRID HSCB anti bait coimmunoprecipitation association 28380382 , (Europe PMC )0.35 IntAct HSPA5 Affinity Capture-MS physical 26496610 , (Europe PMC )NA BioGRID HSPA5 anti tag coimmunoprecipitation association 26496610 , (Europe PMC )0.35 IntAct HSPA8 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HTR7 tandem affinity purification association 19486527 , (Europe PMC )0.35 IntAct HTRA2 Protein-peptide physical 17266347 , (Europe PMC )NA BioGRID IARS Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID IDH3A Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID IKBKG tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct ILK Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification association, physical 23455922 , 25852190 , 26496610 , (Europe PMC )0.64 BioGRID, IntAct IPO4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ITGA4 Affinity Capture-MS physical 22623428 , (Europe PMC )NA BioGRID JUN anti bait coimmunoprecipitation association 25609649 , (Europe PMC )0.35 IntAct, MINT KEAP1 Affinity Capture-MS physical 27621311 , (Europe PMC )NA BioGRID LGALS3BP Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct LGR4 Affinity Capture-MS physical 24639526 , (Europe PMC )NA BioGRID LRFN4 anti tag coimmunoprecipitation association 22677168 , (Europe PMC )0.35 IntAct, MINT MAD2L1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct MAP1LC3A anti tag coimmunoprecipitation association 20562859 , (Europe PMC )0.35 IntAct MAP1LC3B anti tag coimmunoprecipitation association 20562859 , (Europe PMC )0.35 IntAct MAP3K1 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct MAP3K14 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct MAP3K3 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct MAP3K7 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct MAPK6 anti tag coimmunoprecipitation association 26972000 , (Europe PMC )0.35 IntAct MCM2 Affinity Capture-MS physical 25963833 , (Europe PMC )NA BioGRID MCM7 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID MEX3C Affinity Capture-MS, pull down association, physical 22863774 , 26471122 , (Europe PMC )0.35 BioGRID, IntAct, MINT MKS1 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct MTMR11 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID NCOA2 Affinity Capture-MS physical 16051665 , (Europe PMC )NA BioGRID NEDD4 Reconstituted Complex physical 16055720 , (Europe PMC )NA BioGRID NFATC1 Affinity Capture-MS physical 27637333 , (Europe PMC )NA BioGRID NFATC2 Affinity Capture-MS physical 27637333 , (Europe PMC )NA BioGRID NFKB2 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct NFKBIE tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct NOS2 Affinity Capture-MS physical 23438482 , (Europe PMC )NA BioGRID NTRK1 Affinity Capture-MS physical 25921289 , (Europe PMC )NA BioGRID OBSL1 Affinity Capture-MS physical 24711643 , (Europe PMC )NA BioGRID OTUB1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26752685 , (Europe PMC )0.35 BioGRID, IntAct PC Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID POC1B Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct POU5F1 Affinity Capture-MS physical 26687479 , (Europe PMC )NA BioGRID PPEF1 pull down association 28330616 , (Europe PMC )0.35 IntAct PPP2R2B anti tag coimmunoprecipitation association 19156129 , (Europe PMC )0.35 IntAct PPP5C proximity-dependent biotin identification, pull down association 28330616 , (Europe PMC )0.46 IntAct PSMC2 Co-fractionation physical 22939629 , 26344197 , (Europe PMC )NA BioGRID PSMC3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PSMC4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PSMC5 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PSMC6 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PSMD1 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PSMD12 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PSMD2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PSMD4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PTBP3 anti bait coimmunoprecipitation association 22575643 , (Europe PMC )0.35 IntAct, MINT PTPN23 pull down association 28330616 , (Europe PMC )0.35 IntAct RAD21 Affinity Capture-Western physical 22145905 , (Europe PMC )NA BioGRID RC3H1 Affinity Capture-MS physical 26170170 , (Europe PMC )NA BioGRID RELA tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct RELB tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct RIPK1 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct RIPK3 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct RIPK4 anti tag coimmunoprecipitation association 26972000 , (Europe PMC )0.35 IntAct RPS3 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID RPS6KB2 Affinity Capture-MS physical 25324306 , (Europe PMC )NA BioGRID RPS9 anti bait coimmunoprecipitation association 17461779 , (Europe PMC )0.35 IntAct RUVBL1 Co-fractionation physical 22939629 , 26344197 , (Europe PMC )NA BioGRID RUVBL2 Co-fractionation physical 22939629 , 26344197 , (Europe PMC )NA BioGRID SARS Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID SEC16A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct SHC1 Affinity Capture-MS, tandem affinity purification association, physical 19380743 , (Europe PMC )0.35 BioGRID, IntAct SIRT7 Affinity Capture-MS physical 22586326 , (Europe PMC )NA BioGRID SKI Affinity Capture-MS physical 25670202 , (Europe PMC )NA BioGRID SLC25A3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID SMAD2 Affinity Capture-MS, tandem affinity purification physical, physical association 18729074 , (Europe PMC )0.40 BioGRID, IntAct SMARCA4 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SMARCC2 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SPRTN Affinity Capture-MS physical 23254330 , (Europe PMC )NA BioGRID STAU1 Affinity Capture-MS physical 23125841 , (Europe PMC )NA BioGRID SUMO2 Reconstituted Complex physical 19394292 , (Europe PMC )NA BioGRID TAB2 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct TES Affinity Capture-MS physical 28378594 , (Europe PMC )NA BioGRID TNFRSF1A tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct TNFRSF1B tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct TP53 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TP63 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 20085233 , (Europe PMC )0.35 BioGRID, IntAct TRADD tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct TRAF2 tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct TRIM29 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct TUBA1A pull down association 27291054 , 29568061 , (Europe PMC )0.53 IntAct TUBA1C Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct TUBA4A Co-fractionation physical 22939629 , 26344197 , (Europe PMC )NA BioGRID TUBB2A Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID TUBB3 pull down association 27291054 , (Europe PMC )0.35 IntAct TUBB4B Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID TUBG1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID UBR5 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID UQCRC2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID VARS Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID VCAM1 cross-linking study association 22623428 , (Europe PMC )0.35 IntAct VHL Affinity Capture-MS, Affinity Capture-Western physical 28775317 , (Europe PMC )NA BioGRID WWOX Affinity Capture-MS physical 24550385 , (Europe PMC )NA BioGRID XPO1 Co-fractionation physical 22939629 , 26344197 , (Europe PMC )NA BioGRID YAP1 Affinity Capture-MS physical 25796446 , (Europe PMC )NA BioGRID YME1L1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID YWHAZ pull down physical association 15161933 , (Europe PMC )0.40 IntAct, MINT ZNF746 Affinity Capture-MS physical 25315684 , (Europe PMC )NA BioGRID
Phosphorylating Kinases Phosphoresidues Detection Method PubMed IDs Source
Visualize a network of protein kinases and phosphatases phosphorylating and dephosphorylating this protein respectively
CAD T1037_QQCRVLGtSPEAIDS , in vitro, in vivo 11986331 , 12438317 ,(Europe PMC )HPRD, MAPK1 T456_KVYFLPItPHYVTQV , LTP, in vitro 12438317 , 15890648 ,(Europe PMC )HPRD, PhosphoELM , PhosphoSitePlus , MAPK3 T456_KVYFLPItPHYVTQV , LTP 15890648 ,(Europe PMC )PhosphoELM , PhosphoSitePlus , PKA_group S1406_GAGGRRLsSFVTKGY , LTP 14991569 , 17206380 , 17485345 ,(Europe PMC )PhosphoELM , PRKACA S1406_GAGGRRLsSFVTKGY , S1859_PPRIHRAsDPGLPAE , in vitro, in vivo 11986331 , 17322306 , 18669648 , 18691976 , 18707149 , 18767875 , 19651622 , 19664994 , 19664995 , 20068231 , 4092695 ,(Europe PMC )HPRD, PhosphoSitePlus , RPS6KB1 S1859_PPRIHRAsDPGLPAE , NA NA PhosphoSitePlus , Unknown S1038_QCRVLGTsPEAIDSA , S1073_RELSDLEsARQFCQT , S10_ALVLEDGsVLRGQPF , S1406_GAGGRRLsSFVTKGY , S1407_AGGRRLSsFVTKGYR , S1823_AVPQLPPsAPATSEM , S1859_PPRIHRAsDPGLPAE , S1900_PPVPRQAsPQNLGTP , S1920_QTSPLLHsLVGQHIL , T172_KTPRVFNtGGAPRIL , T1884_AEPELMGtPDGTCYP , T1906_ASPQNLGtPGLLHPQ , T375_QTVRERLtERLCPPG , HTP, in vivo 16964243 , 17081983 , 17322306 , 18669648 , 18691976 , 18707149 , 18767875 , 19651622 , 19664994 , 19664995 , 20068231 ,(Europe PMC )HPRD, PhosphoELM ,
Statistics
