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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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KEGG Pathway - Sphingolipid metabolism

Phosphatases known in this pathway

NameSynonymsUniProt ACDephosphorylate substrates:
PPAP2A (QuickGO)PAP2aO14494ceramide 1-phosphate lysophosphatidic acid phosphatidic acid sphingosine 1-phosphate
PPAP2B (QuickGO)PAP2bO14495ceramide 1-phosphate lysophosphatidic acid phosphatidic acid sphingosine 1-phosphate
PPAP2C (QuickGO)PAP2cO43688ceramide 1-phosphate lysophosphatidic acid phosphatidic acid sphingosine 1-phosphate
SGPP2 (QuickGO)SPP2Q8IWX5sphinganine 1-phosphate sphingosine 1-phosphate
SGPP1 (QuickGO)SPP1Q9BX95phytosphingosine 1-phosphate sphinganine 1-phosphate sphingosine 1-phosphate

Substrates known in this pathway

NameSynonymsUniProt ACDephosphorylated by phosphatases:
Arylsulfatase AArylsulfatase A (ASA) (EC 3.1.6.8) (Cerebroside-sulfatase) [Cleaved into: Arylsulfatase A component B; Arylsulfatase A component C]P15289TR-AP
SK1Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91)Q9NYA1PP2Aalpha PP2Abeta
ceramide 1-phosphateCeramide 1-phosphate; ceramide 1-phosphates; Ceramide phosphate; N-(acyl)-sphing-4-enine-1-phosphate; N-Acyl ceramide phosphateN/APAP2a PAP2b PAP2c
O-phosphoethanolamine2-amino-ethanol dihydrogen phosphate; 2-amino-ethanol phosphate; colamine phosphate; colamine phosphoric acid; colaminphosphoric acid; EAP; ethanolamine acid phosphate; ethanolamine O-phosphate; ethanolamine?O-phosphate; Ethanolamine phosphate; mono(2-aminoethyl) phosphate; monoaminoethyl phosphate; O-phosphocolamine; O-Phosphoethanolamine; O-Phosphorylethanolamine; OPE; PE; PEA; PETN; pEtN; Phosphoethanolamine; phosphonoethanolamine; phosphoric acid 2-aminoethyl phenyl esterN/APHOSPHO1
sphinganine 1-phosphate(2S,3R)-2-amino-3-hydroxyoctadecyl dihydrogen phosphate; Dihydrosphingosine 1-phosphate; dihydrosphingosine-1-phosphate; Sphinganine 1-phosphate; dihydro-S1PN/ASPP1 SPP2
sphingosine 1-phosphate(2S,3R,4E)-2-amino-4-octadecene-1,3-diol 1-(dihydrogen phosphate); Sphing-4-enine 1-phosphate; Sphingosine 1-phosphate; sphingosine-1-phosphate; S1PN/APAP2a PAP2b PAP2c SPP1 SPP2

Sorry, no phosphatase/substrate known in this pathway here!

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