Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
last update: 18 Feb, 2016


KEGG Pathway - Osteoclast differentiation

Phosphatases known in this pathway

NameSynonymsUniProt ACDephosphorylate substrates:
ACP5 (QuickGO)TR-APP13686Arylsulfatase A mannose 6-phosphate glycoproteins
PPP3CB (QuickGO)PP2BbetaP16298alpha-crystallin A chain BAD c-Jun Calcipressin-1 Calnexin CKI-epsilon DARPP32 DRP1 DYN2 Dynamin-1 ELK1 Filamin-A GAD65 GAD67 GSK-3 beta HSP27 IPP-1 KSR2 NFAT1 NFH NTCP RIIalpha slingshot-1 TAU VASP
PPP3CC (QuickGO)PP2BgammaP48454alpha-crystallin A chain BAD c-Jun Calcipressin-1 Calnexin CKI-epsilon DARPP32 DRP1 DYN2 Dynamin-1 ELK1 Filamin-A GAD65 GAD67 GSK-3 beta HSP27 IPP-1 KSR2 NFAT1 NFH NTCP RIIalpha slingshot-1 TAU VASP
PPP3CA (QuickGO)PP2BalphaQ08209alpha-crystallin A chain BAD c-Jun Calcipressin-1 Calnexin CKI-epsilon DARPP32 DRP1 DYN2 Dynamin-1 ELK1 Filamin-A GAD65 GAD67 GSK-3 beta HSP27 IPP-1 KSR2 NFAT1 NFH NTCP RIIalpha slingshot-1 TAU VASP

Substrates known in this pathway

NameSynonymsUniProt ACDephosphorylated by phosphatases:
IKKBInhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)O14920PP2Aalpha PP2Abeta PP2Calpha PP2Cbeta PP2Ceta
IKKAInhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)O15111PP2Aalpha PP2Abeta
TAK1Mitogen-activated protein kinase kinase kinase 7 (EC (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)O43318PP2Aalpha PP2Abeta PP2Cbeta PP2Cepsilon PP6
c-JunTranscription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)P05412PP2Balpha PP2Bbeta PP2Bgamma
LCKTyrosine-protein kinase Lck (EC (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)P06239CD45 LYP SAP1 SHP1
FYNTyrosine-protein kinase Fyn (EC (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)P06241BDP1 CD45 RPTPalpha RPTPepsilon RPTPeta STEP
CD32Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32)P12318LMW-PTP
CREB1Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1)P16220PP2Aalpha PP2Abeta PTEN
JAK1Tyrosine-protein kinase JAK1 (EC (Janus kinase 1) (JAK-1)P23458CD45 TCPTP
IkB-alphaNF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)P25963PTP-BAS PTP1B
ERK1Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (Mitogen-activated protein kinase 1) (MAP kinase 1) (MAPK 1) (p44-ERK1)P27361CDC25A DUPD1 HePTP hVH3 MKP-1 MKP-2 MKP-4 MKP-6 MOSP RPTPepsilon RPTPeta VHR
PI3K regulatory subunit alphaPhosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)P27986PP2Calpha RPTPeta
ERK2Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)P28482CDC25A DUPD1 HePTP hVH3 JSP-1 MKP-1 MKP-2 MKP-3 MKP-4 MKP-X PAC-1 PP2Aalpha PP2Abeta RPTPepsilon RPTPeta VHR
TYK2Non-receptor tyrosine-protein kinase TYK2 (EC PTP1B
PKBRAC-alpha serine/threonine-protein kinase (EC (Protein kinase B) (PKB) (Proto-oncogene c-Akt) (RAC-PK-alpha)P31749LMW-PTP PHLPP1 PHLPP2 PP1alpha PP1beta PP1gamma PP2Aalpha PP2Abeta
PKB betaRAC-beta serine/threonine-protein kinase (EC (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC-PK-beta)P31751PHLPP1 PHLPP2
STAT1Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)P42224SHP2 TCPTP
JNK1Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC (JNK-46) (Stress-activated protein kinase 1) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)P45983hVH5 JSP-1 LMW-DSP20 MKP-1 MKP-4 MKP-5 PP2Aalpha PP2Abeta VHR
JNK2Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC (JNK-55) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)P45984MKP-1 MKP-2 MKP-4 MKP-5 MKP-6 MKP-7 SKRP1 VHR
MEK6Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC (MAPK/ERK kinase 6) (MEK 6) (SAPKK3)P52564PP2Calpha
MAP kinase p38gammaMitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)P53778PTPH1
JNK3Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC (MAP kinase p49 3F12) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)P53779MKP-7
SHPS-1Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)P78324SHP2
MEK1Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)Q02750PP2Aalpha PP2Abeta
NF-kappa-B p65Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)Q04206PP2Aalpha PP4c
NFAT1Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1)Q13469PP2Balpha PP2Bbeta PP2Bgamma
MAP kinase p38alphaMitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (SAPK2A)Q16539DUPD1 HePTP hVH5 JSP-1 MKP-1 MKP-4 MKP-5 MKP-6 MKP-8 PAC-1 PP2Aalpha PP2Abeta PP2Calpha PP2Cdelta VHR
CaMK IVCalcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC (CaM kinase-GR)Q16566CaMKP-N CaMKPase PP2Aalpha PP2Abeta
GAB2GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)Q9UQC2SHP1 SHP2
PKB gammaRAC-gamma serine/threonine-protein kinase (EC (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)Q9Y243PHLPP1 PHLPP2 PP2Aalpha PP2Abeta
TRAF2TNF receptor-associated factor 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)Q12933PP2Aalpha PP2Abeta
Ins(1,4,5)P31,4,5-Insp3; 1D-myo-Inositol 1,4,5-trisphosphate; D-myo-Inositol 1,4,5-trisphosphate; D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE; Inositol 1,4,5-trisphosphate; Ins(1,4,5)P3; InsP3; IP3N/AINPP5A INPP5B INPP5E INPP5J INPP5K OCRL-1 Synaptojanin-1 Synaptojanin-2

Sorry, no phosphatase/substrate known in this pathway here!