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INPP5A
Localization (UniProt annotation) Membrane; Lipid-anchor Function (UniProt annotation) Major isoenzyme hydrolyzing the calcium-mobilizingsecond messenger Ins(1,4,5)P3, this is a signal-terminatingreaction Catalytic Activity (UniProt annotation) D-myo-inositol 1,4,5-trisphosphate + H(2)O =myo-inositol 1,4-bisphosphate + phosphate 1D-myo-inositol 1,3,4,5-tetrakisphosphate +H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate Protein Sequence MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDA
MKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECK
WSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSK
SVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGTALLEFDKELSVFKDRLYELD
ISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKELVLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGK
PHAHVHKCCVVQ
ELM Motif Motif Instance Description Motif Regex NA NA NA NA
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol. Inositol phosphates IP2, IP and the six-carbon cyclic alcohol inositol (Ins) are produced by various phosphatases and the inositol-3-phosphate synthase 1 (ISYNA1) (Ju et al. 2004, Ohnishi et al. 2007, Irvine & Schell 2001, Bunney & Katan 2010)
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source HNRNPL Affinity Capture-RNA physical 28611215 , (Europe PMC )NA BioGRID IGHA1 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID ISOC2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ITFG2 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID MED21 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PRPS2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID RABGGTB Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID RCCD1 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID SLC25A41 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID TTC1 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID YWHAZ Reconstituted Complex physical 9398266 , (Europe PMC )NA BioGRID ZG16B Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source HNRNPL Affinity Capture-RNA physical 28611215 , (Europe PMC )NA BioGRID IGHA1 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID ISOC2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ITFG2 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID MED21 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PLEK affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, enzymatic study association, direct interaction 8999861 , (Europe PMC )0.63 IntAct, MINT PLEKHA7 anti bait coimmunoprecipitation association 28877994 , (Europe PMC )0.35 IntAct PRPS2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID RABGGTB Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID RCCD1 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID SLC25A41 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID TTC1 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID YWHAZ Reconstituted Complex physical 9398266 , (Europe PMC )NA BioGRID ZG16B Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID