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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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KEGG Pathway - Phosphatidylinositol signaling system

Phosphatases known in this pathway

NameSynonymsUniProt ACDephosphorylate substrates:
IMPA2 (QuickGO)IMP 2O14732adenosine 2'-phosphate alpha-D-glucose 1-phosphate beta-D-glucose 1-phosphate glycerol 2-phosphate Ins(1,4)P2 Ins(1)P1 Ins(2)P1 Ins(3)P1 Ins(4)P1 Ins(5)P1 Ins(6)P1 scyllo-inositol 1,4-bisphosphate
SYNJ2 (QuickGO)Synaptojanin-2O15056Ins(1,3,4,5)P4 Ins(1,4,5)P3 PtdIns(3,4,5)P3 PtdIns(4,5)P2
INPP4B (QuickGO)INPP4BO15327Ins(1,3,4)P3 Ins(1,4)P2 Ins(3,4)P2 PtdIns(3,4)P2
INPPL1 (QuickGO)SHIP2O15357Ins(1,2,3,4,5)P5 Ins(1,3,4,5)P4 Ins(1,4,5,6)P4 Ins(2,4,5,6)P4 PtdIns(3,4,5)P3 PtdIns(3,5)P2
SYNJ1 (QuickGO)Synaptojanin-1O43426Ins(1,3,4,5)P4 Ins(1,4,5)P3 PtdIns(3,4,5)P3 PtdIns(4,5)P2
IMPA1 (QuickGO)IMP 1P29218adenosine 2'-phosphate alpha-D-glucose 1-phosphate alpha-D-glucose 6-phosphate beta-D-glucose 1-phosphate beta-D-glucose 6-phosphate D-fructose 1-phosphate glycerol 2-phosphate Ins(1,4)P2 Ins(1)P1 Ins(2)P1 Ins(3)P1 Ins(4)P1 Ins(5)P1 Ins(6)P1 scyllo-inositol 1,3-bisphosphate scyllo-inositol 1,4-bisphosphate scyllo-inositol monophosphate
INPP5B (QuickGO)INPP5BP32019Ins(1,3,4,5)P4 Ins(1,4,5)P3 PtdIns(3,4,5)P3 PtdIns(4,5)P2
INPP1 (QuickGO)IPPaseP49441Ins(1,3,4)P3 Ins(1,4)P2
PTEN (QuickGO)PTENP60484CREB1 FAK Ins(1,3,4,5)P4 PDGFRB PtdIns(3,4,5)P3 PtdIns(3,4)P2 PtdIns(3,5)P2 PtdIns(3)P PTEN SHC1
OCRL (QuickGO)OCRL-1Q01968Ins(1,3,4,5)P4 Ins(1,4,5)P3 PtdIns(3,4,5)P3 PtdIns(4,5)P2
INPP5A (QuickGO)INPP5AQ14642Ins(1,3,4,5)P4 Ins(1,4,5)P3
INPP5J (QuickGO)INPP5JQ15735Ins(1,3,4,5)P4 Ins(1,4,5)P3 PtdIns(4,5)P2
INPP5D (QuickGO)SHIP1Q92835Ins(1,3,4,5)P4 PtdIns(3,4,5)P3
INPP4A (QuickGO)INPP4AQ96PE3Ins(1,3,4)P3 Ins(3,4)P2 PtdIns(3,4)P2
INPP5K (QuickGO)INPP5KQ9BT40Ins(1,3,4,5)P4 Ins(1,4,5)P3 PtdIns(3,4,5)P3 PtdIns(4,5)P2
INPP5E (QuickGO)INPP5EQ9NRR6Ins(1,3,4,5)P4 Ins(1,4,5)P3 PtdIns(3,4,5)P3 PtdIns(4,5)P2

Substrates known in this pathway

NameSynonymsUniProt ACDephosphorylated by phosphatases:
PKC-betaProtein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)P05771PHLPP1 PHLPP2 PP1alpha PP2Aalpha PP2Abeta
PKC-alphaProtein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)P17252PHLPP1 PHLPP2 PP1alpha PP1beta PP1gamma PP2Aalpha PP2Abeta
PLC-gamma-11-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)P19174PTP1B RPTPeta
PI3K regulatory subunit alphaPhosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)P27986PP2Calpha RPTPeta
PTENPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)P60484PTEN
Ins(1)P11D-myo-Inositol 1-monophosphate; 1D-myo-Inositol 1-phosphate; D-myo-Inositol 1-phosphate; Inositol 1-phosphate; Inositol 1-phosphate; Myoinositol 1-phosphate; Ins(1)P1N/AIMP 1 IMP 2
Ins(1,3)P21D-myo-Inositol 1,3-bisphosphate; D-myo-inositol 1,3-bisphosphate; D-myo-Inositol 1,3-bisphosphate; Inositol 1,3-bisphosphate; myo-Inositol 1,3-bisphosphate; PHOSPHORIC ACID MONO-(2,3,4,6-TETRAHYDROXY-5-PHOSPHONOOXY-CYCLOHEXYL) ESTER; Ins(1,3)P2N/AMTM1 MTMR2 MTMR7
Ins(1,3,4)P3(1S,3S,4S)-1,3,4-TRIPHOSPHO-MYO-INOSITOL; 1D-myo-inositol 1,3,4-trisphosphate; 1D-myo-Inositol 1,3,4-trisphosphate; D-myo-Inositol 1,3,4-trisphosphate; Inositol 1,3,4-trisphosphate; Ins(1,3,4)P3N/ABPNT1 INPP4A INPP4B IPPase
Ins(1,3,4,5)P41D-myo-inositol 1,3,4,5-tetrakisphosphate; 1D-myo-Inositol 1,3,4,5-tetrakisphosphate; D-myo-Inositol 1,3,4,5-tetrakisphosphate; Inositol 1,3,4,5-tetrakisphosphate; Ins(1,3,4,5)P4N/AINPP5A INPP5B INPP5E INPP5J INPP5K MINPP1 OCRL-1 PTEN SHIP1 SHIP2 Synaptojanin-1 Synaptojanin-2 TPIP
Ins(1,4)P21D-myo-Inositol 1,4-bisphosphate; D-myo-Inositol 1,4-bisphosphate; D-MYO-INOSITOL-1,4-BISPHOSPHATE; Inositol 1,4-bisphosphate; myo-inositol 1,4-bisphosphate; myo-Inositol 1,4-bisphosphate; Ins(1,4)P2N/ABPNT1 IMP 1 IMP 2 INPP4B IPPase
Ins(1,4,5)P31,4,5-Insp3; 1D-myo-Inositol 1,4,5-trisphosphate; D-myo-Inositol 1,4,5-trisphosphate; D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE; Inositol 1,4,5-trisphosphate; Ins(1,4,5)P3; InsP3; IP3N/AINPP5A INPP5B INPP5E INPP5J INPP5K OCRL-1 Synaptojanin-1 Synaptojanin-2
Ins(3)P11D-myo-Inositol 3-monophosphate; 1D-myo-Inositol 3-phosphate; 1L-myo-Inositol 1-phosphate; D-myo-Inositol 3-monophosphate; D-myo-Inositol 3-phosphate; Inositol 3-phosphate; L-myo-Inositol 1-phosphate; Myoinositol 3-phosphate; Ins(3)P1N/AIMP 1 IMP 2
Ins(3,4)P21D-myo-Inositol 3,4-bisphosphate; D-myo-Inositol 3,4-bisphosphate; Inositol 3,4-bisphosphate; Ins(3,4)P2N/AINPP4A INPP4B
Ins(4)P11D-myo-Inositol 4-monophosphate; 1D-myo-Inositol 4-phosphate; D-myo-Inositol 4-phosphate; Ins(4)P1N/AIMP 1 IMP 2
InsP61D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate; D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate; myo-inositol 1,2,3,4,5,6-hexakisphosphate; myo-Inositol hexakisphosphate; Phytate; Phytic acid; InsP6N/AMINPP1
phosphatidic acid1,2-Diacyl-sn-glycerol 3-phosphate; 3-sn-Phosphatidate; Phosphatidate; phosphatidic acid; Phosphatidic acid; phosphatidic acids; PA; 1,2-diacylglycerol 3-phosphateN/AACPP DPPL1 DPPL2 Lipin 1 Lipin 2 Lipin 3 LPPR2 LPPR3 LPPR4 PAP2a PAP2b PAP2c PPAPDC2
PtdIns(3)P1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3'-phosphate); 1-Phosphatidyl-1D-myo-inositol 3-phosphate; Phosphatidylinositol 3-phosphate; PtdIns-3-P; PtdIns3P; PtdIns(3)P; PI3PN/AMTM1 MTMR1 MTMR14 MTMR2 MTMR3 MTMR4 MTMR6 MTMR7 PTEN PTPS31 SAC1
PtdIns(3,4)P21-phosphatidyl-1D-myo-inositol 3,4-bisphosphate; 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate; 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate pentaanion; PtdIns(3,4)P2; PI(3,4)P2N/AINPP4A INPP4B PTEN PTPS31
PtdIns(3,4,5)P31,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate); 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate; 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate; Phosphatidylinositol-3,4,5-trisphosphate; PIP3; PtsIns(3,4,5)P3; PtsIns-3,4,5-P3; PtdIns(3,4,5)P3; PI(3,4,5)P3N/AC1-TEN FIG4 INPP5B INPP5E INPP5K OCRL-1 PTEN PTPS31 SAC2 SHIP1 SHIP2 Synaptojanin-1 Synaptojanin-2 TPIP
PtdIns(3,5)P21,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',5'-bisphosphate); 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate; 1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate; PtsIns(3,5)P2; PtsIns-3,5-P2; PtdIns(3,5)P2; PI(3,5)P2N/AFIG4 MTM1 MTMR1 MTMR14 MTMR2 MTMR3 MTMR6 MTMR7 PTEN PTPS31 SHIP2 TPIP
PtdIns(4)P1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-4'-phosphate); 1-phosphatidyl-1D-myo-inositol 4-monophosphate; 1-Phosphatidyl-1D-myo-inositol 4-phosphate; Phosphatidylinositol 4-phosphate; PtdIns-4-P; PtdIns4P; PtdIns(4)P; PI4PN/APTPS31 SAC1
PtdIns(4,5)P21,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-4',5'-bisphosphate); 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate; 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate; 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate; 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate; Phosphatidyl-myo-inositol 4,5-bisphosphate; Phosphatidyl-myo-inositol 4,5-bisphosphate; Phosphatidylinositol-4,5-bisphosphate; Phosphatidylinositol-4,5-bisphosphate; PIP2; PIPP; PtsIns(4,5)P2; PtsIns-4,5-P2; PtdIns(4,5)P2; PI(4,5)P2N/AFIG4 INPP5B INPP5E INPP5J INPP5K OCRL-1 PRL-3 PTPS31 SAC2 Synaptojanin-1 Synaptojanin-2
PtdIns(5)P1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate); 1-phosphatidyl-1D-myo-inositol 5-phosphate; 1-Phosphatidyl-1D-myo-inositol 5-phosphate; PIP; PtdIns-5-P; PtdIns5P; PtdIns(5)P; PI5PN/APTPS31

Sorry, no phosphatase/substrate known in this pathway here!

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